3-BroMo-5-(trifluoroMethyl)anisole

light yellow liquid

Preparation of intermediate3-Methoxy-5-(trifluoromethyl)benzenamine (20 g, 104. 6 mmol) was added portion- wise to a cooled solution of NaN0d) Preparation of Intermediate 4 3-Methoxy-5-(trifluoromethyl)benzenamine (20 g, 104.6 mmol) was added portion-wise to a cooled solution of NaNOA mixture of 3-(tert-butyl)-5-methylphenol (1.5 g, 9.13 mmol), iodomethane (1.43 g, 10mmol) and K2C03 (1.89 g, 13.7 mmol) in acetone (20 mL) was heated with stuffing at 60 °C for3 hrs. The mixture was cooled down to rt and filtered. The filtrate was concentrated in vacuo to give crude 1-bromo-3-methoxy-5-(trifluoromethyl)benzene (1.98 g) which was used in the next step without further purification.A mixture of 3-(tert-butyl)-5-methylphenol (1.5 g, 9.13 mmol), iodomethane (1.43 g, 10mmol) and K2C03 (1.89 g, 13.7 mmol) in acetone (20 mL) was heated with stuffing at 60 C for3 hrs. The mixture was cooled down to rt and filtered. The filtrate was concentrated in vacuo to give crude To a mixture of Step 2: Preparation of 8-[3-methoxy-5-(trifluoromethyl)phenyl]-1, 4-dioxa-8- azaspiro[4.5]decane To a mixture of

Molecular Weight:255.03
XLogP3:3.5
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:1
Exact Mass:253.95541
Monoisotopic Mass:253.95541
Topological Polar Surface Area:9.2
Heavy Atom Count:13
Complexity:171
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes