4-BENZYL-2-HYDROXY-MORPHOLIN-3-ONE
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4-BENZYL-2-HYDROXY-MORPHOLIN-3-ONE
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CAS No:
287930-73-8
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Formula:
C11H13NO3
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Chemical Name:
4-BENZYL-2-HYDROXY-MORPHOLIN-3-ONE
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Synonyms:
4-BENZYL-2-HYDROXY-MORPHOLIN-3-ONE;3-Morpholinone,2-hydroxy-4-(phenylMethyl)-;2-Hydroxy-4-(phenylMethyl)-3-Morpholinone;Fosaprepitant Impurity B
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CAS No:
4-BENZYL-2-HYDROXY-MORPHOLIN-3-ONE Basic Attributes
207.23
207.089539
1806241-263-5
DTXSID60433133
2934999090
Safety Information
P264, P280, P302+P352, P305+P351+P338, P321, P332+P313, P337+P313, P362
H315
|Warning|H315 (100%): Causes skin irritation [Warning Skin corrosion/irritation]|P264, P280, P302+P352, P305+P351+P338, P321, P332+P313, P337+P313, and P362|The GHS information provided by 1 company from 1 notification to the ECHA C&L Inventory.
4-BENZYL-2-HYDROXY-MORPHOLIN-3-ONE Use and Manufacturing
To a 250ml reaction flask was added 50percent glyoxylic acid (67ml, 0.61mol) and tetrahydrofuran (130ml), heated to reflux, was added dropwise N- benzyl ethanolamine (41.5g, 0.27mol) in tetrahydrofuran (20ml) solution, to the reaction complete, the tetrahydrofuran was evaporated, water (170ml), cooled with stirring, to precipitate a solid, ice-water bath was stirred for 30 minutes, filtered and washed with ice water, drying in a yellowish solid, i.e. compounds of formula VII (51.8g, 91percent), mp132 ~ 136 .
For the treatment of depression and chemotherapy-induced vomiting; can prevent acute and delayed nausea and vomiting caused by repeated chemotherapy for the first time and later
Computed Properties
Molecular Weight:207.23
XLogP3:0.3
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:2
Exact Mass:207.08954328
Monoisotopic Mass:207.08954328
Topological Polar Surface Area:49.8
Heavy Atom Count:15
Complexity:226
Undefined Atom Stereocenter Count:1
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes
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4-BENZYL-2-HYDROXY-MORPHOLIN-3-ONE
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