2-(3-bromopyridin-2-yl)acetonitrile
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2-(3-bromopyridin-2-yl)acetonitrile
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CAS No:
122851-60-9
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Formula:
C7H5BrN2
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Chemical Name:
2-(3-bromopyridin-2-yl)acetonitrile
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Synonyms:
2-(3-bromopyridin-2-yl)acetonitrile;(3-BROMOPYRIDIN-2-YL)ACETONITRILE;3-BroMo-2-pyridineacetonitrile;3-Bromopyridine-2-acetonitrile
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CAS No:
Characteristics
36.7
1.2
1.575±0.06 g/cm3(Predicted)
63-64 °C(Solv: ethyl ether (60-29-7))
279.5±25.0 °C(Predicted)
122.8ºC
1.578
0.004mmHg at 25°C
2-(3-bromopyridin-2-yl)acetonitrile Use and Manufacturing
To the solution of MeCN (87 mg, 2.13 mmol) in THF (8 mL) was added n-BuLi (1.78 mL, 4.26 mmol) at -78 To a stirred solution of the above crude 3-bromo-2-bromomethylpyridine (70g, 0. 28MOL) in dioxane (SOOML) and water (250mL), was added NACN (28g, 0. 74MOL) at 0°C and then stirred at RT for 16h. The reaction mixture was quenched with 3Lit of water and extracted with ethylacetate (4X500ML). The organic layer was washed with water (400L), brine (250mL), dried over NA2SO4 and concentrated to give crude product. The crude was purified by column chromatography over silica gel (pet. ether/ethylacetate, 8: 2) to give 3- BROMOPYRIDINE-2-YL-ACETONITRILE (22g, 40percent). [TLC: Pet. ether/ethylacetate, 7: 3, RF= 0. 35] MS (EST) : 199.2 ; MS (ESR) : 197.2.
Computed Properties
Molecular Weight:197.03
XLogP3:1.2
Hydrogen Bond Acceptor Count:2
Rotatable Bond Count:1
Exact Mass:195.96361
Monoisotopic Mass:195.96361
Topological Polar Surface Area:36.7
Heavy Atom Count:10
Complexity:149
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes
Recommended Suppliers of 2-(3-bromopyridin-2-yl)acetonitrile
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Business licensed Certified factoryManufactory Supplier of 4-(Pentafluorothio)aniline,Pentafluoro,Pentafluorothio,Pentafluorosulfur,[4-(bromomethyl)phenyl]-pentafluoro-lambda6-sulfane,[4-(pentafluoro-sulfanyl)phenyl]acetic acidInquiryCAS No.: 122851-60-9Grade: Industrial GradeContent: 95%
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2-(3-bromopyridin-2-yl)acetonitrile
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