4-Bromo-5-fluoro-2-nitrobenzenamine
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4-Bromo-5-fluoro-2-nitrobenzenamine
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CAS No:
153505-36-3
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Formula:
C6H4BrFN2O2
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Chemical Name:
4-Bromo-5-fluoro-2-nitrobenzenamine
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Synonyms:
Benzenamine,4-bromo-5-fluoro-2-nitro-;4-Bromo-5-fluoro-2-nitrobenzenamine;4-Bromo-5-fluoro-2-nitroaniline;4-Bromo-5-fluoro-2-nitrophenylamine
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CAS No:
4-Bromo-5-fluoro-2-nitrobenzenamine Use and Manufacturing
Intermediate 1 IB; 4-bromo-5 -fluoro-2-nitroaniline; To A^-(4-bromo-5-fluoro-2-nitrophenyl)-2, 2, 2-trifluoroacetamide (3.5 g, 10.5 mmol) was added CHΛA(4-Bromo-5-fluoro-2-nitrophenyl)-2, 2, 2-trifluoroacetamide was dissolved in1 , 4-dioxane (80 mL) with stirring. Aqueous 1 N sodium hydroxide solution (50 ml_) was added, and the mixture was stirred for 45 minutes. The reaction was heated to 50 To a flask was added 5-fluoro-2-nitroaniline (8.9 g, 57 mmol), NBS (10 g, 56 mmol), and acetic acid (500 mL), and the reaction was heated to 110 °C. Example 10 N4 -(5-Cyclopropyl-lH-pyrazol-3-yl)- N2 -((6-fluoro-lH-benzo[d]imidazol-5-yl)methyl)pyrimidine-2, 4- diamine (1-28) step 1 : A solution of 5-fluoro-2-nitroaniline (1.5 g, 9.61 mmol) and NBS (1.7 g, 9.55 mmol) in HO Ac (75 mL) was heated at reflux for 90 min. The reaction mixture was then poured into ice water (300 mL) and stirred for 10 min. A bright yellow precipitate was collected by filtration and dried in vacuo overnight to afford 1.57 g (76percent) of 4-bromo-5-fluoro-2-nitroaniline (96): MS (ESI) m/z = 235 [M+l] +.INTERMEDIATE 16; 4-Bromo-5-fluoro-2-nitrophenylaminePotassium nitrate (914 mg, 9.05 mmol) was added to a stirred solution of 4-bromo- 3-fluoroacetanilide (2 g, 8.6 mmol) in sulfuric acid (10 mL) at r.t. After 1.5 h the mixture was poured onto ice (approximately 100 g) and extracted with EtOAc (100 mL). The organic phase was dried (MgSO4-Bromo-5-fluoro-1, 2-diaminobenzene 4-Bromo-5-fluoro-1, 2-diaminobenzene was prepared using an adaptation of the method of Bellamy et al. (Bellamy, F. D. et al., Tetrahedron Lett. 25:839 (1984)). A mixture of 4-Bromo-5-fluoro-1, 2-diaminobenzene 4-Bromo-5-fluoro-1, 2-diaminobenzene was prepared using an adaptation of the method of Bellamy et al. (Bellamy, F. D. et al., Tetrahedron Lett. 25:839 (1984)). A mixture of
Computed Properties
Molecular Weight:235.01
XLogP3:2.4
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:4
Exact Mass:233.94402
Monoisotopic Mass:233.94402
Topological Polar Surface Area:71.8
Heavy Atom Count:12
Complexity:187
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes
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4-Bromo-5-fluoro-2-nitrobenzenamine
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