Fosamprenavir calcium
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Fosamprenavir calcium
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CAS No:
226700-81-8
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Formula:
C25H36N3O9PS.Ca
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Chemical Name:
Fosamprenavir calcium
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Synonyms:
Carbamic acid,N-[(1S,2R)-3-[[(4-aminophenyl)sulfonyl](2-methylpropyl)amino]-1-(phenylmethyl)-2-(phosphonooxy)propyl]-,(3S)-tetrahydro-3-furanyl ester,calcium salt (1:1);Carbamic acid,[(1S,2R)-3-[[(4-aminophenyl)sulfonyl](2-methylpropyl)amino]-1-(phenylmethyl)-2-(phosphonooxy)propyl]-,C-[(3S)-tetrahydro-3-furanyl] ester,calcium salt (1:1);GW 433908G;Fosamprenavir calcium;Lexiva;Telzir
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CAS No:
Description
GW433908 is a phosphate ester prodrug of the antiretroviral protease inhibitor amprenavir, with improved solubility over the parent molecule and a potential for reduced pill burden on current dosing regimens; GW433908G is the calcium salt of the prodrug.IC50 Value:Target: HIV Proteasein vitro: There were no significant changes in buprenorphine or PI plasma levels and no significant changes in medication adverse effects or opioid withdrawal. Increased concentrations of the inactive metabo
Fosamprenavir Calcium is the calcium salt form of fosamprenavir, prodrug of amprenavir, and a human immunodeficiency virus (HIV) protease inhibitor with antiviral property. Fosamprenavir is converted to amprenavir by cellular phosphatases in the epithelial cells of the intestine. Then amprenavir binds to the active site of HIV-1 protease, thereby preventing the proteolytic cleavage of viral Gag-Pol polypeptide into individual functional proteins, thereby leading to the formation of immature non-infectious viral particles.
Fosamprenavir calcium Basic Attributes
623.668921
623.137939
1806241-263-5
ID1GU2627N
DTXSID0046777
C61771
J05AE07
Safety Information
P201, P202, P260, P264, P280, P281, P302+P352, P308+P313, P314, P321, P332+P313, P362, P405, P501
H315
|Warning|H315 (33.33%): Causes skin irritation [Warning Skin corrosion/irritation]|P201, P202, P260, P263, P264, P270, P280, P281, P302+P352, P308+P313, P314, P321, P332+P313, P362, P405, and P501|Aggregated GHS information provided by 3 companies from 3 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.
Drug Information
Telzir in combination with low-dose ritonavir is indicated for the treatment of human-immunodeficiency-virus-type-1-infected adults, adolescents and children of six years and above in combination with other antiretroviral medicinal products.In moderately antiretroviral-experienced adults, Telzir in combination with low-dose ritonavir has not been shown to be as effective as lopinavir / ritonavir. No comparative studies have been undertaken in children or adolescents.In heavily pretreated patients, the use of Telzir in combination with low-dose ritonavir has not been sufficiently studied.In protease-inhibitor-experienced patients, the choice of Telzir should be based on individual viral resistance testing and treatment history.
Agents used to treat AIDS and/or stop the spread of the HIV infection. These do not include drugs used to treat symptoms or opportunistic infections associated with AIDS. (See all compounds classified as Anti-HIV Agents.)|Inhibitors of HIV PROTEASE, an enzyme required for production of proteins needed for viral assembly. (See all compounds classified as HIV Protease Inhibitors.)
(3-(((4-aminophenyl)sulfonyl)(2-methylpropyl)amino)-1-(phenylmethyl)-2-(phosphonooxy)propyl)carbamic acid C-(tetrahydro-3-furanyl) ester
Fosamprenavir calcium Use and Manufacturing
Protease inhibitor, anti-HIV agent
Human drugs -> Telzir -> EMA Drug Category|Antivirals for systemic use -> Human pharmacotherapeutic group|Human Drugs -> FDA Approved Drug Products with Therapeutic Equivalence Evaluations (Orange Book) -> Active Ingredients
Computed Properties
Molecular Weight:623.7
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:11
Rotatable Bond Count:13
Exact Mass:623.1379287
Monoisotopic Mass:623.1379287
Topological Polar Surface Area:192
Heavy Atom Count:40
Complexity:901
Defined Atom Stereocenter Count:3
Covalently-Bonded Unit Count:2
Compound Is Canonicalized:Yes
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