Captopril-Hydrochlorothiazide mixt.
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Captopril-Hydrochlorothiazide mixt.
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CAS No:
110075-07-5
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Formula:
C9H15NO3S.C7H8ClN3O4S2
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Chemical Name:
Captopril-Hydrochlorothiazide mixt.
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Synonyms:
L-Proline,1-[(2S)-3-mercapto-2-methyl-1-oxopropyl]-,mixt. with 6-chloro-3,4-dihydro-2H-1,2,4-benzothiadiazine-7-sulfonamide 1,1-dioxide;L-Proline,1-(3-mercapto-2-methyl-1-oxopropyl)-,(S)-,mixt. with 6-chloro-3,4-dihydro-2H-1,2,4-benzothiadiazine-7-sulfonamide 1,1-dioxide;2H-1,2,4-Benzothiadiazine-7-sulfonamide,6-chloro-3,4-dihydro-,1,1-dioxide,mixt. contg.;Captopril TZ;Capozide;Captopril-Hydrochlorothiazide mixt.;Captopress;Dosturel
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CAS No:
Drug Information
A class of drugs whose main indications are the treatment of hypertension and heart failure. They exert their hemodynamic effect mainly by inhibiting the renin-angiotensin system. They also modulate sympathetic nervous system activity and increase prostaglandin synthesis. They cause mainly vasodilation and mild natriuresis without affecting heart rate and contractility. (See all compounds classified as Angiotensin-Converting Enzyme Inhibitors.)|Agents that inhibit SODIUM CHLORIDE SYMPORTERS. They act as DIURETICS. Excess use is associated with HYPOKALEMIA. (See all compounds classified as Sodium Chloride Symporter Inhibitors.)|Drugs used in the treatment of acute or chronic vascular HYPERTENSION regardless of pharmacological mechanism. Among the antihypertensive agents are DIURETICS; (especially DIURETICS, THIAZIDE); ADRENERGIC BETA-ANTAGONISTS; ADRENERGIC ALPHA-ANTAGONISTS; ANGIOTENSIN-CONVERTING ENZYME INHIBITORS; CALCIUM CHANNEL BLOCKERS; GANGLIONIC BLOCKERS; and VASODILATOR AGENTS. (See all compounds classified as Antihypertensive Agents.)
Capozide
Captopril-Hydrochlorothiazide mixt. Use and Manufacturing
Human Drugs -> FDA Approved Drug Products with Therapeutic Equivalence Evaluations (Orange Book) -> Active Ingredients
Computed Properties
Molecular Weight:515.0
Hydrogen Bond Donor Count:5
Hydrogen Bond Acceptor Count:11
Rotatable Bond Count:4
Exact Mass:514.0417403
Monoisotopic Mass:514.0417403
Topological Polar Surface Area:194
Heavy Atom Count:31
Complexity:738
Defined Atom Stereocenter Count:2
Covalently-Bonded Unit Count:2
Compound Is Canonicalized:Yes
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