3-Bromo-5-chloro-1H-indazole
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3-Bromo-5-chloro-1H-indazole
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CAS No:
885521-43-7
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Formula:
C7H4BrClN2
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Chemical Name:
3-Bromo-5-chloro-1H-indazole
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Synonyms:
3-Bromo-5-chloro-1H-indazole;3-bromo-5-chloro-2H-indazole;3-Bromo-5-chloro (1H)indazole;3-Bromo-5-chloro(1H)indazole;5-CHLORO-3-BROMO-INDAZOLE;SCHEMBL15332567;CTK5G0751;1H-Indazole,3-bromo-5-chloro-;DTXSID10646256;3-bromanyl-5-chloranyl-2H-indazole
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CAS No:
Safety Information
IRRITANT
P261, P264, P270, P271, P280, P301+P312, P302+P352, P304+P312, P304+P340, P312, P322, P330, P363, P501
H302
|Warning|H302 (100%): Harmful if swallowed [Warning Acute toxicity, oral]|P261, P264, P270, P271, P280, P301+P312, P302+P352, P304+P312, P304+P340, P312, P322, P330, P363, and P501|The GHS information provided by 1 company from 1 notification to the ECHA C&L Inventory.
3-Bromo-5-chloro-1H-indazole Use and Manufacturing
To a solution of 5-chloro- 1H-indazole (2.5 g, 16.1 mmol) in dichloromethane (150 mL) was added N-bromosuccinimide (2.9 g, 16.6 mmol) and the mixture was stirred at room temperature for 1 hour. The mixture was concentrated under reduced pressure and the residue was dissolved in ethyl acetate (100 mL), washed with water (50 mL) and brine (50 mL), dried over sodium sulfate and concentrated under reduced pressure to afford 3-bromo-5-chloro-1H-indazole (3.7 g, 94percent) as a brown solid. ‘H NMR (DMSO-d6, 400 MHz) 13.63 (s, 1H), 7.67 — 7.59 (m, 2H), 7.49 — 7.44 (m, 1H). TLC: 50percent ethyl acetate/heptane (R1: 0.43).To a solution of 5-chloro- 1H-indazole (2.5 g, 16.1 mmol) in dichloromethane (150 mL) was added N-bromosuccinimide (2.9 g, 16.6 mmol) and the mixture was stirred at room temperature for 1 hour. The mixture was concentrated under reduced pressure and the residue was dissolved in ethyl acetate (100 mL), washed with water (50 mL) and brine (50 mL), dried over sodium sulfate and concentrated under reduced pressure to afford 3-bromo-5-chloro-1H-indazole (3.7 g, 94percent) as a brown solid. ‘H NMR (DMSO-d6, 400 MHz) 13.63 (s, 1H), 7.67 — 7.59 (m, 2H), 7.49 — 7.44 (m, 1H). TLC: 50percent ethyl acetate/heptane (R1: 0.43).
Computed Properties
Molecular Weight:231.48
XLogP3:3.2
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:1
Exact Mass:229.92464
Monoisotopic Mass:229.92464
Topological Polar Surface Area:28.7
Heavy Atom Count:11
Complexity:155
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes
Recommended Suppliers of 3-Bromo-5-chloro-1H-indazole
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Business licensed Certified factoryManufactory Supplier of 4-(Pentafluorothio)aniline,Pentafluoro,Pentafluorothio,Pentafluorosulfur,[4-(bromomethyl)phenyl]-pentafluoro-lambda6-sulfane,[4-(pentafluoro-sulfanyl)phenyl]acetic acidInquiryCAS No.: 885521-43-7Grade: Industrial GradeContent: 95%
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