5-BROMO-N-METHYLPYRIDIN-2-AMINE

2, 5-Dibromopyridinc (2.5 g, 10.6 mmol) was treated with a 33percent MeNHSynthesis of (5-bromo-pyridin-2-yl)-methyl-amine 2-fluoro-5-bromopyridine (2.00 g, 11.37 mmol), methylamine-hydrochloride (1.92 g, 28.40 mmol) and JV-ethyldiisopropylamine (2.14 mL, 12.50 mmol) in NMP (10 mL) are stirred for 40 min in a microwave reactor at 140A mixture of 5-bromo-2-chloropyridine (3g, 15.5 mmol), methylamine hydrochloride (3.16 g, 46.8 mmol), and DIPEA (8.17 mL, 46.8 mmol) was heated at 170°C under microwave for 4 h. The mixture was diluted with water and extracted with EtOAc. The organic layers was separated and washed with brine. Organic layer was dried over anhydrous Na2SO4 and concentrated. The residue was applied to ISCO (24g silica gel, solid loading, 70-80percent ethyl acetate/hexane) to afford 5-bromo-N-methylpyridin-2- amine (800 mg, 4.28 mmol, 27.4 percent yield) as a brown solid.A solution of 5-bromo-2-fluoropyridine (2.5 g, 14 mmol) in THF (50 mL) was stirred with a solution of methylamine in THF (c=2 mol/L) (35 mL, 70 mmol) at 23° C. for 16 h. Water was added and the mixture was extracted with ether, the organic layer was dried over Naa)

Molecular Weight:187.04
XLogP3:1.9
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:2
Rotatable Bond Count:1
Exact Mass:185.97926
Monoisotopic Mass:185.97926
Topological Polar Surface Area:24.9
Heavy Atom Count:9
Complexity:87.1
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes