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Home > Encyclopedia > P-(3-Aminopropyl)-P-(diethoxymethyl)phosphinic acid

P-(3-Aminopropyl)-P-(diethoxymethyl)phosphinic acid

P-(3-Aminopropyl)-P-(diethoxymethyl)phosphinic acid structure

P-(3-Aminopropyl)-P-(diethoxymethyl)phosphinic acid 

structure
  • CAS No:

    123690-79-9

  • Formula:

    C8H20NO4P

  • Chemical Name:

    P-(3-Aminopropyl)-P-(diethoxymethyl)phosphinic acid

  • Synonyms:

    Phosphinic acid,P-(3-aminopropyl)-P-(diethoxymethyl)-;Phosphinic acid,(3-aminopropyl)(diethoxymethyl)-;P-(3-Aminopropyl)-P-(diethoxymethyl)phosphinic acid;CGP 35348;(3-Aminopropyl)(diethoxymethyl)phosphinic acid

  • Categories:

    Organic Chemistry  >  Phosphines

P-(3-Aminopropyl)-P-(diethoxymethyl)phosphinic acid Basic Attributes

225.22

225.22

87TI61875H

DTXSID70154064

Characteristics

81.8

1.66250

white solid

1.131g/cm3

400.5ºC at 760mmHg

196ºC

1.459

H2O: >10 mg/mL

−20°C

Safety Information

3

Drug Information

Drugs that bind to but do not activate GABA RECEPTORS, thereby blocking the actions of endogenous GAMMA-AMINOBUTYRIC ACID and GABA RECEPTOR AGONISTS. (See all compounds classified as GABA Antagonists.)

CGP 35348

P-(3-Aminopropyl)-P-(diethoxymethyl)phosphinic acid Use and Manufacturing

Selective, brain penetrant GABA B receptor antagonist (IC 50 = 34 μ M as measured in rat cortical membranes). Has higher affinity for postsynaptic versus presynaptic receptors.

Computed Properties

Molecular Weight:225.22
XLogP3:-3.3
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:5
Rotatable Bond Count:8
Exact Mass:225.11299512
Monoisotopic Mass:225.11299512
Topological Polar Surface Area:81.8
Heavy Atom Count:14
Complexity:182
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes

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