4-Chloro-3-iodo-1-(4-Methoxybenzyl)-1H-pyrazolo[4,3-c]pyridine

To a solution of 4-chloro-3-iodo-lH-pyrazolo[4, 3-c]pyridine (2.00 g, 7.17 mmol) in DMF (30 mL) was added KOH (0.800 g, 14.3 mmol) and l-(chloromethyl)-4- methoxybenzene (2.24 g, 14.3 mmol). The mixture was stirred at room temperature overnight. After concentration, the residue was purified by silica gel column chromatography eluting with petroleum ether/ethyl acetate (10:1 to 8:1) to give the title compound as a white solid (2.4 g, 82percent).To a solution of 4-chloro-3-iodo-1H-pyrazolo[4, 3-c]pyridine (2.00 g, 7.17 mmol) in DMF (30 mL) was added KOH (0.800 g, 14.3 mmol) and 1-(chloromethyl)-4-methoxybenzene (2.24 g, 14.3 mmol). The mixture was stirred at room temperature overnight. After concentration, the residue was purified by silica gel column chromatography eluting with petroleum ether/ethyl acetate (10:1 to 8:1) to give the title compound as a white solid (2.4 g, 82percent).

Molecular Weight:399.61
XLogP3:3.7
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:3
Exact Mass:398.96354
Monoisotopic Mass:398.96354
Topological Polar Surface Area:39.9
Heavy Atom Count:20
Complexity:328
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes