Fenoldopam mesylate
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Fenoldopam mesylate
structure -
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CAS No:
67227-57-0
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Formula:
C16H16ClNO3.CH4O3S
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Chemical Name:
Fenoldopam mesylate
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Synonyms:
1H-3-Benzazepine-7,8-diol,6-chloro-2,3,4,5-tetrahydro-1-(4-hydroxyphenyl)-,methanesulfonate (1:1);1H-3-Benzazepine-7,8-diol,6-chloro-2,3,4,5-tetrahydro-1-(4-hydroxyphenyl)-,methanesulfonate (salt);SKF 82526J;Fenoldopam mesylate;Fenoldopam methanesulfonate;Corlopam;Fenoldopam monomethanesulfonate;87900-91-2
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CAS No:
Description
Fenoldopam(SKF 82526) mesylate is a drug and synthetic benzazepine derivative which acts as a selective D1 receptor partial agonist.Target: D1 ReceptorFenoldopam is a selective dopamine-1 (DA1) agonist with natriuretic/diuretic properties. Fenoldopam stimulated cAMP accumulation in LLC-PK1 cells in a dose-dependent manner, an effect which could be blocked by the DA1-selective antagonist Sch 23390. Although fenoldopam was more potent than DA (EC50 55.5 +/- 7.75 nM vs. 1.65 +/- 0.64 microM
Fenoldopam mesylate is a benzazepine.|A dopamine D1 receptor agonist that is used as an antihypertensive agent. It lowers blood pressure through arteriolar vasodilation.
Characteristics
136
white to tan
1.38g/cm3
274 °C (decomp)
269.9ºC
DMSO: ≥15mg/mL at ~60°C
room temp
Safety Information
NONH for all modes of transport
3
22-36-42/43
22-26-36/37/39
Xn
P280-P301 + P312 + P330-P305 + P351 + P338
H302-H317-H319
|Warning|H302 (100%): Harmful if swallowed [Warning Acute toxicity, oral]|P261, P264, P270, P272, P280, P301+P312, P302+P352, P305+P351+P338, P321, P330, P333+P313, P337+P313, P363, and P501|Aggregated GHS information provided by 39 companies from 2 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.
Drug Information
Drugs that bind to and activate dopamine receptors. (See all compounds classified as Dopamine Agonists.)|Drugs used in the treatment of acute or chronic vascular HYPERTENSION regardless of pharmacological mechanism. Among the antihypertensive agents are DIURETICS; (especially DIURETICS, THIAZIDE); ADRENERGIC BETA-ANTAGONISTS; ADRENERGIC ALPHA-ANTAGONISTS; ANGIOTENSIN-CONVERTING ENZYME INHIBITORS; CALCIUM CHANNEL BLOCKERS; GANGLIONIC BLOCKERS; and VASODILATOR AGENTS. (See all compounds classified as Antihypertensive Agents.)|Drugs used to cause dilation of the blood vessels. (See all compounds classified as Vasodilator Agents.)
Corlopam
Fenoldopam mesylate Use and Manufacturing
antihypertensive, dopamine agonist
Human Drugs -> FDA Approved Drug Products with Therapeutic Equivalence Evaluations (Orange Book) -> Active Ingredients
Computed Properties
Molecular Weight:401.9
Hydrogen Bond Donor Count:5
Hydrogen Bond Acceptor Count:7
Rotatable Bond Count:1
Exact Mass:401.0699862
Monoisotopic Mass:401.0699862
Topological Polar Surface Area:136
Heavy Atom Count:26
Complexity:441
Undefined Atom Stereocenter Count:1
Covalently-Bonded Unit Count:2
Compound Is Canonicalized:Yes
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