Casopitant mesylate
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Casopitant mesylate
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CAS No:
414910-30-8
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Formula:
C30H35F7N4O2.CH4O3S
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Chemical Name:
Casopitant mesylate
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Synonyms:
1-Piperidinecarboxamide,4-(4-acetyl-1-piperazinyl)-N-[(1R)-1-[3,5-bis(trifluoromethyl)phenyl]ethyl]-2-(4-fluoro-2-methylphenyl)-N-methyl-,(2R,4S)-,methanesulfonate (1:1);1-Piperidinecarboxamide,4-(4-acetyl-1-piperazinyl)-N-[(1R)-1-[3,5-bis(trifluoromethyl)phenyl]ethyl]-2-(4-fluoro-2-methylphenyl)-N-methyl-,(2R,4S)-,monomethanesulfonate;4-(S)-(4-Acetylpiperazin-1-yl)-2-(R)-(4-fluoro-2-methylphenyl)piperidine-1-carboxylic acid N-[1-(R)-(3,5-bis-trifluoromethylphenyl)ethyl]-N-methylamide methanesulfonate;GW 679769B;Casopitant mesylate
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CAS No:
Description
Casopitant Mesylate is the mesylate salt of a centrally-acting neurokinin 1 (NK1) receptor antagonist with antidepressant and antiemetic activities. Casopitant competitively binds to and blocks the activity of the NK-receptor, thereby inhibiting NK1-receptor binding of the endogenous tachykinin neuropeptide substance P (SP), which may result in antiemetic effects. SP is found in neurons of vagal afferent fibers innervating the brain-stem nucleus tractus solitarii and the area postrema, which contains the chemoreceptor trigger zone (CTZ), and may be elevated in response to chemotherapy. The NK-receptor is a G-protein receptor coupled to the inositol phosphate signal-transduction pathway and is found in both the nucleus tractus solitarii and the area postrema.
Safety Information
|Danger|H302 (100%): Harmful if swallowed [Warning Acute toxicity, oral]|P260, P264, P270, P273, P280, P301+P312, P305+P351+P338, P310, P314, P330, P391, and P501|The GHS information provided by 1 company from 1 notification to the ECHA C&L Inventory.
Drug Information
Drugs used to prevent NAUSEA or VOMITING. (See all compounds classified as Antiemetics.)|Compounds that inhibit or block the activity of NEUROKININ-1 RECEPTORS. (See all compounds classified as Neurokinin-1 Receptor Antagonists.)
casopitant
Casopitant mesylate Use and Manufacturing
It is a novel, orally active tachykinin NK1 receptor antagonist; efficacy of Casopitant mesilate in patients receiving emetogenic chemotherapy
Computed Properties
Molecular Weight:712.7
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:13
Rotatable Bond Count:4
Exact Mass:712.25293867
Monoisotopic Mass:712.25293867
Topological Polar Surface Area:110
Heavy Atom Count:48
Complexity:1040
Defined Atom Stereocenter Count:3
Covalently-Bonded Unit Count:2
Compound Is Canonicalized:Yes
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