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2-CHLORO-1,8-NAPHTHYRIDINE

2-CHLORO-1,8-NAPHTHYRIDINE structure

CAS No:
15936-10-4
Formula:
C8H5ClN2
Chemical Name:
2-CHLORO-1,8-NAPHTHYRIDINE
Synonyms:
2-CHLORO-1,8-NAPHTHYRIDINE;1,8-Naphthyridine, 2-chloro-
Categories:
Pharmaceutical Intermediates > Heterocyclic Compound

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2-CHLORO-1,8-NAPHTHYRIDINE Basic Attributes

Molecular Weight：

164.59

Exact Mass：

164.01400

DSSTox ID：

DTXSID30408919

Characteristics

PSA：

25.8

XLogP3：

2.4

Density：

1.349±0.06 g/cm3(Predicted)

Melting Point：

138-139 °C

Boiling Point：

281.5±20.0 °C(Predicted)

Flash Point：

151.002ºC

Refractive Index：

1.663

Vapor Pressure：

0.006mmHg at 25°C

Safety Information

GHS Classification：

|Warning|H302 (100%): Harmful if swallowed [Warning Acute toxicity, oral]|P261, P264, P270, P271, P280, P301+P312, P302+P352, P304+P340, P305+P351+P338, P312, P321, P330, P332+P313, P337+P313, P362, P403+P233, P405, and P501|The GHS information provided by 1 company from 1 notification to the ECHA C&L Inventory.

2-CHLORO-1,8-NAPHTHYRIDINE Use and Manufacturing

2-Chloro-1 8-naphthvridine; Phosphorous oxychloride (86 ml, 924 mmol) was added to 1, 8-naphthyridin-2-one [Journal of Organic Chemistry 1990, 55 (15), 4744-50] (9.00 g, 61.6 mmol), and the resulting mixture heated to 100°C for 1 hour. The mixture was cooled and the excess phosphorous oxychloride was removed by evaporation. The residue was taken up in dichloromethane (100 ml) and carefully basified by the addition of sat. NaHCO3. The organic layer was separated and dried over Na2SO4, filtered, and evaporated to give the title compound as a white solid (7 g, 70percent). 1H NMR (400 MHz, CDCl3) 7.50 (1 H, d, J8.4), 7.52 (l H, dd, J8. 1 and 4.3), 8.16 (1 H, d, J- 8. 4), 8. 22 (1 H, dd, J8.1 and 2.0), 9.12 (1 H, dd, J4.3 and 2.0).Example 26

Computed Properties

Molecular Weight:164.59
XLogP3:2.4
Hydrogen Bond Acceptor Count:2
Exact Mass:164.0141259
Monoisotopic Mass:164.0141259
Topological Polar Surface Area:25.8
Heavy Atom Count:11
Complexity:140
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes

Recommended Suppliers of 2-CHLORO-1,8-NAPHTHYRIDINE

HANGZHOU LEAP CHEM CO., LTD. Contact Supplier

CN
5 YRS

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Trader Supplier of Intermediates,Building blocks,API,Silicones,Peptides,Lab chemicals,Biochemicals,Pharmaceuticals,Screening Compounds,Food Additives

2-CHLORO-1,8-NAPHTHYRIDINE

CAS No.: 15936-10-4

Content: 99.00%

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Henan Ouber Technology Co., Ltd. Contact Supplier

CN
6 YRS

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Manufactory Supplier of OLED intermedaites,Pharmaceutical intermediates,Ligands and catalysts

2-chloro-1,8-naphthyridine / 15936-10-4

CAS No.: 15936-10-4

Grade: Chemical Grade

Content: 99%

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Guide of 2-CHLORO-1,8-NAPHTHYRIDINE

Basic Attributes
Characteristics
Safety Information
Use and Manufacturing
Computed Properties
Recommended Suppliers
Latest News
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2-CHLORO-1,8-NAPHTHYRIDINE

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