4-CHLORO-2-METHOXYBENZALDEHYDE
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4-CHLORO-2-METHOXYBENZALDEHYDE
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CAS No:
53581-86-5
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Formula:
C8H7ClO2
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Chemical Name:
4-CHLORO-2-METHOXYBENZALDEHYDE
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Synonyms:
4-CHLORO-2-METHOXYBENZALDEHYDE
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CAS No:
Safety Information
3
20/21/22
Xn
|Warning|H312 (100%): Harmful in contact with skin [Warning Acute toxicity, dermal]|P280, P302+P352, P312, P322, P363, and P501|Aggregated GHS information provided by 128 companies from 2 notifications to the ECHA C&L Inventory.
4-CHLORO-2-METHOXYBENZALDEHYDE Use and Manufacturing
4-Chloro-2-Fluorobenzaldehyde (300 mg, 1.89 mmol) was diluted with NaOMe (3784 μL, 1.89 mmol) (solution in methanol), heated to 50General procedure: To a stirred solution of substrate (1 mmol, arylhalide/olefinic halide) in suitable alcohol (MeOH/EtOH, 10 mL), sodiumcarbonate (1.06 g, 2 mol percent) was added and the reaction mixture was refluxed(MeOH = 65 C/EtOH = 78 C) for specified time. On completion, the reactionmixture was filtered, washed with methanol and dried in vacuo. The residuewas taken in ethyl acetate (20 mL) and washed with water. Organic layer wasdried over anhydrous sodium sulfate and evaporated in vacuo. The residuethus obtained was purified through Flash chromatography using ethyl acetate–hexane system. All the compounds were characterized and confirmed bycomparison of their spectral data and physical properties with reportedliterature