6-Chloro-1H-benzimidazole-2-methanol

21 a)A mixture of 4-chlorobenzene-1, 2-diamine (105 g, 736 mmoles, 1 eq.) andhydroxyacetic acid (112 g, 2 eq.) in xylene (1500 mL) was stirred at 150 °C for 4 hours. The mixture was then cooled to 60 °C and treated with 3N HC1 (480 ml), then basified to pH=7-8 by the addition of aqueous ammonia. The mixture was filtered and the solid was collected, washed with H20 and tert-butyl methyl ether to give 123 g (82percent yield) of (5 -chloro- 1 H-benzo [d]imidazo l-2-yl)methano 1 21 a.A mixture of 4-chlorobenzene-1, 2-diamine (105 g, 736 mmoles, 1 eq.) and hydroxyacetic acid (112 g, 2 eq.) in xylene (1500 mL) was stirred at 150°C for 4 hours. The mixture was then cooled to 60°C and treated with 3N HC1 (480 ml), then basified to pH = 7-8 by the addition of aqueous ammonia. The mixture was filtered and the solid was collected, washed with H20 and tert-butyl methyl ether to give 123 g (82percent yield) of (5 -chloro- 1 H-benzo [d]imidazol-2-yl)methanol (7a).

Molecular Weight:182.61
XLogP3:1.6
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:2
Rotatable Bond Count:1
Exact Mass:182.0246905
Monoisotopic Mass:182.0246905
Topological Polar Surface Area:48.9
Heavy Atom Count:12
Complexity:167
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes