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2-Chloro-5-(trifluoromethyl)pyridine

2-Chloro-5-(trifluoromethyl)pyridine structure

CAS No:
52334-81-3
Formula:
C6H3ClF3N
Chemical Name:
2-Chloro-5-(trifluoromethyl)pyridine
Synonyms:
Pyridine,2-chloro-5-(trifluoromethyl)-;2-Chloro-5-(trifluoromethyl)pyridine;5-Trifluoromethyl-2-chloropyridine
Categories:
Pharmaceutical Intermediates > Heterocyclic Compound

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Description

white to yellowish crystalline low melting solid

2-Chloro-5-(trifluoromethyl)pyridine Basic Attributes

Molecular Weight：

181.54

Exact Mass：

181.54

BRN：

3649688

EC Number：

257-856-5

UNII：

C9G66D966B

DSSTox ID：

DTXSID8075251

HScode：

2933399090

Characteristics

PSA：

12.9

XLogP3：

2.7

Appearance：

White to yellow Crystalline Low Melting Solid

Density：

1.4±0.1 g/cm3

Melting Point：

33 °C

Boiling Point：

153 °C

Flash Point：

>230 °F

Refractive Index：

1.447

Storage Conditions：

0-6°C

Safety Information

Packing level：

III

Hazard category：

6.1

Transport codes：

2811

wgk germany：

hazard class code：

36/37/38-20/21/22-25-11

safety instructions：

26-37/39-36/37/39-45-22-16

RTECS Number：

US7530000

Marks：

Xi,Xn,T,F

Hazard note：

Irritant

Stability/Shelf Life：

Stable at room temperature in closed containers under normal storage and handling conditions.

Precautionary statement(s)：

P261-P305 + P351 + P338

Hazard Statements：

H315-H319-H335

GHS Classification：

|Warning|H302 (59.62%): Harmful if swallowed [Warning Acute toxicity, oral]|P201, P202, P261, P264, P270, P271, P280, P281, P301+P312, P302+P352, P304+P312, P304+P340, P305+P351+P338, P308+P313, P312, P321, P322, P330, P332+P313, P337+P313, P362, P363, P403+P233, P405, and P501|Aggregated GHS information provided by 104 companies from 8 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.

2-Chloro-5-(trifluoromethyl)pyridine Use and Manufacturing

Methods of Manufacturing

The preparation method takes 3-methylpyridine as the raw material, firstly chlorinates to obtain 2-chloro-5-trichloromethylpyridine, and then further fluorinates to obtain the product; it can also use 3-methylpyridine as the raw material, The fluorochlorination reaction is carried out in the presence of a catalyst to obtain the product. It is also possible to use 2-chloro-5-methylpyridine as a raw material, firstly chlorinate the side chain to 2-chloro-5-trichloromethylpyridine with chlorine gas, and then fluorinate the product with hydrogen fluoride.

Uses

Pesticide intermediates; pharmaceutical intermediates; liquid crystal material intermediates

Computed Properties

Molecular Weight:181.54
XLogP3:2.7
Hydrogen Bond Acceptor Count:4
Exact Mass:180.9906113
Monoisotopic Mass:180.9906113
Topological Polar Surface Area:12.9
Heavy Atom Count:11
Complexity:136
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes

Price Analysis

Make your 2-Chloro-5-(trifluoromethyl)pyridine purchase based on the price and market insights! ECHEMI provides professional market insights with prices for you to make a better choice. Learn more on 2-Chloro-5-(trifluoromethyl)pyridine prices .

Recommended Suppliers of 2-Chloro-5-(trifluoromethyl)pyridine

HANGZHOU LEAP CHEM CO., LTD. Contact Supplier

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2-Chloro-5-trifluoromethylpyridine

CAS No.: 52334-81-3

Content: 99.00%

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Henan Lihao Chem Plant Limited Contact Supplier

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CAS No.: 52334-81-3

Grade: Industrial Grade

Content: 99%

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Guide of 2-Chloro-5-(trifluoromethyl)pyridine

Description
Basic Attributes
Characteristics
Safety Information
Use and Manufacturing
Computed Properties
Price Analysis
Recommended Suppliers
Latest News
Learn More Other Chemicals

2-Chloro-5-(trifluoromethyl)pyridine

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