1,14-Dibromo-3,6,9,12-tetraoxatetradecane
-
1,14-Dibromo-3,6,9,12-tetraoxatetradecane
structure -
-
CAS No:
57602-02-5
-
Formula:
C10H20Br2O4
-
Chemical Name:
1,14-Dibromo-3,6,9,12-tetraoxatetradecane
-
Synonyms:
3,6,9,12-Tetraoxatetradecane,1,14-dibromo-;1,14-Dibromo-3,6,9,12-tetraoxatetradecane;1,2-Bis[2-(2-bromoethoxy)ethoxy]ethane
- Categories:
-
CAS No:
Description
Bromo-PEG4-bromide is a PEG-based PROTAC linker can be used in the synthesis of PROTACs[1].
Characteristics
36.9
1.2
1.5±0.1 g/cm3
169-173 °C @ Press: 1.8 Torr
152.9±23.6 °C
1.489
Refrigerator
1,14-Dibromo-3,6,9,12-tetraoxatetradecane Use and Manufacturing
General procedure: To a solution of the diol (1.0 eq) in pyridine, methanesulfonyl chloride (3.0 eq) was added dropwise at 0C. The reaction mixture was stirred at room temperature for 3 h. The reaction was washed with HCl (1 M) and NaHCO 3 (aq), extracted with CH 2Cl 2 and dried with Na 2SO 4. The solvent was removed in vacuo and the residue was dissolved in acetone. Lithium bromide (4 eq) was added. The reaction mixture was stirred and heated up to reflux overnight. The reaction was concentrated in vacuo and the crude product was purified by chromatography to obtain the product.Pentaethyleneglycol disulfonate (3.94 g, 10 mmol) and 13.3 g tetrabutyl ammonium bromide are dissolved in acetonitrile 50 mL, and stirred and react 16 hours under nitrogen gas protection. Solvent is evaporated out, acetic ether and water are added for extraction, extract is dried by using anhydrous sodium sulfate, concentrates and goes through column separation to obtain 2.73 g product, with a yield rate 75%. 1H-NMR (CDCl3): 3.49 (t, 4H), 3.69 (s, 12H), 3.84 (t, 4H).
A cross-linking reagent.
Computed Properties
Molecular Weight:364.07
XLogP3:1.2
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:13
Exact Mass:363.97078
Monoisotopic Mass:361.97283
Topological Polar Surface Area:36.9
Heavy Atom Count:16
Complexity:113
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes
Recommended Suppliers of 1,14-Dibromo-3,6,9,12-tetraoxatetradecane
-
![China]()
CN
3 YRS
Business licensed Certified factoryManufactory Supplier of 4-(Pentafluorothio)aniline,Pentafluoro,Pentafluorothio,Pentafluorosulfur,[4-(bromomethyl)phenyl]-pentafluoro-lambda6-sulfane,[4-(pentafluoro-sulfanyl)phenyl]acetic acidInquiryCAS No.: 57602-02-5Grade: Industrial GradeContent: 95%
Learn More Other Chemicals
-
2-Bromophenacyl bromide, 90%
49851-55-0
-
1H-Indazol-7-ol
81382-46-9
-
6-Chloro-4-forMyl-nicotinic acid
1031433-06-3
-
3-Hydroxy-2,4,5-trifluorobenzoic acid Formula
116751-24-7
-
2-Methyl-1-heptene Formula
15870-10-7
-
1-(3,5-Dinitrophenyl)ethanone Formula
14401-75-3
-
α-Amino-3-bromobenzeneacetic acid Structure
79422-73-4
-
6-(BROMOMETHYL)-1,3-BENZOTHIAZOLE,97% Structure
499770-85-3
-
What is Allyl methacrylate
96-05-9
-
What is ethyl 5-hydroxy-2-Methylnicotinate
60390-47-8
1,14-Dibromo-3,6,9,12-tetraoxatetradecane
SDSRequest for Quotation