Lodenosine
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Lodenosine
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CAS No:
110143-10-7
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Formula:
C10H12FN5O2
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Chemical Name:
Lodenosine
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Synonyms:
9H-Purin-6-amine,9-(2,3-dideoxy-2-fluoro-β-D-threo-pentofuranosyl)-;9-(2,3-Dideoxy-2-fluoro-β-D-threo-pentofuranosyl)-9H-purin-6-amine;2′-β-Fluoro-2′,3′-dideoxyadenosine;Lodenosine;9-(2,3-Dideoxy-2-fluoro-β-D-threo-pentofuranosyl)adenine;F-ddA;NSC 613792;Lodensine
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CAS No:
Description
Lodenosine is a nucleoside reverse transcriptase inhibitor analog of adenosine. Lodenosine is a synthetic purine fluoro-dideoxyadenosine derivative that was rationally designed to have improved chemical and enzymatic stability. It has shown activity against clinical isolates and cell lines that are resistant to AZT, dideoxyinosine, and dideoxycytosine.
Characteristics
99.1
0.60760
1.85±0.1 g/cm3(Predicted)
226-227 °C @ Solvent: Ethanol, Water
541.3±60.0 °C(Predicted)
281.2ºC
1.795
1.5E-12mmHg at 25°C
Computed Properties
Molecular Weight:253.23
XLogP3:-0.2
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:7
Rotatable Bond Count:2
Exact Mass:253.09750280
Monoisotopic Mass:253.09750280
Topological Polar Surface Area:99.1
Heavy Atom Count:18
Complexity:310
Defined Atom Stereocenter Count:3
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes
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