2-Cyano-3-(1-phenyl-1H-indol-3-yl)-2-propenoic acid
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2-Cyano-3-(1-phenyl-1H-indol-3-yl)-2-propenoic acid
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CAS No:
56396-35-1
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Formula:
C18H12N2O2
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Chemical Name:
2-Cyano-3-(1-phenyl-1H-indol-3-yl)-2-propenoic acid
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Synonyms:
2-Propenoic acid,2-cyano-3-(1-phenyl-1H-indol-3-yl)-;2-Cyano-3-(1-phenyl-1H-indol-3-yl)-2-propenoic acid;UK 5099;2-Cyano-3-(1-phenyl-1H-indol-3-yl)-acrylic acid
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CAS No:
Description
UK-5099 is a potent inhibitor of the mitochondrial pyruvate carrier (MPC). UK-5099 ihibits pyruvate-dependent O2 consumption with an IC50 of 50 nM.
Characteristics
68.85000
2.28738
yellow to tan
1.2±0.1 g/cm3
448.6°C at 760 mmHg
225.1±28.7 °C
1.634
DMSO: >20mg/mL
Store at +4°C
2-Cyano-3-(1-phenyl-1H-indol-3-yl)-2-propenoic acid Use and Manufacturing
Pyruvate transport into mitochondria is facilitated by mitochondrial pyruvate carrier (MPC) 1 and 2, two small transmembrane proteins that are part of a larger 150 kDa protein transport complex in the inner mitochondrial membrane.UK 5099 is a specific and potent inhibitor of MPC carrier activity. It potently inhibits pyruvate-dependent oxygen consumption by rat heart mitochondria with an IC50 value of 50 nM.
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2-Cyano-3-(1-phenyl-1H-indol-3-yl)-2-propenoic acid
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