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3-Deazauridine

3-Deazauridine structure

CAS No:
23205-42-7
Formula:
C10H13NO6
Chemical Name:
3-Deazauridine
Synonyms:
2(1H)-Pyridinone,4-hydroxy-1-β-D-ribofuranosyl-;2(1H)-Pyridone,4-hydroxy-1-β-D-ribofuranosyl-;4-Hydroxy-1-β-D-ribofuranosyl-2(1H)-pyridinone;3-Deazauridine;4-Hydroxy-1-(β-D-ribofuranosyl)-2-pyridone;1-β-D-Ribofuranosyl-4-hydroxy-2-pyridone;NSC 126849;3-Deazuridine
Categories:
Biochemical Engineering > Saccharides

Description

3-Deazauridine is a synthetic analogue of nucleoside uridine lacking a ring nitrogen in the 3-position. 3-deazauridine inhibits cytidine synthase, thereby reducing intracellular levels of cytidine and deoxycytidine and disrupting DNA and RNA synthesis. This agent may trigger apoptosis and enhance differentiation of neoplastic cells.(NCI04)|4-Hydroxy-1-(beta-D-ribofuranosyl)-2-pyridinone. Analog of uridine lacking a ring-nitrogen in the 3-position. Functions as an antineoplastic agent.

3-Deazauridine Basic Attributes

Molecular Weight：

243.21

Exact Mass：

243.21

EC Number：

245-488-8

UNII：

263CU738ZY

NCI Thesaurus Code：

C193

Characteristics

PSA：

111

XLogP3：

-1.8

Density：

1.718g/cm3

Melting Point：

233-235°C

Boiling Point：

528ºC at 760mmHg

Flash Point：

273.1ºC

Refractive Index：

1.706

Storage Conditions：

-20°C

Vapor Pressure：

0mmHg at 25°C

Safety Information

RTECS Number：

UV1148000

Drug Information

MeSH：

Antimetabolites that are useful in cancer chemotherapy. (See all compounds classified as Antimetabolites, Antineoplastic.)

MeSH Entry Terms：

3 Deazauridine

3-Deazauridine Use and Manufacturing

Antimetabolite antiviral dosing regimen for hepatitis C virus or flaviviridae therapy.

Computed Properties

Molecular Weight:243.21
XLogP3:-1.8
Hydrogen Bond Donor Count:4
Hydrogen Bond Acceptor Count:6
Rotatable Bond Count:2
Exact Mass:243.07428713
Monoisotopic Mass:243.07428713
Topological Polar Surface Area:111
Heavy Atom Count:17
Complexity:379
Defined Atom Stereocenter Count:4
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes

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3-Deazauridine

CAS No.: 23205-42-7

Content: 99.00%

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Guide of 3-Deazauridine

Description
Basic Attributes
Characteristics
Safety Information
Drug Information
Use and Manufacturing
Computed Properties
Recommended Suppliers
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3-Deazauridine

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