Efaproxiral sodium

Efaproxiral sodium is a synthetic allosteric modifier of haemoglobin (Hb), decreases Hb-oxygen (O2) binding affinity and enhances oxygenation of hypoxic tumours during radiation therapy.in vitro: Efaproxiral increases oxygen levels in hypoxic tumor tissues by binding non-covalently to the hemoglobin tetramer and decreasing hemoglobin-oxygen binding affinity. Increasing tumor oxygenation reduces tumor radioresistance. Efaproxiral can enhance the oxygenation of hypoxic tumours and function

Efaproxiral Sodium is the sodium salt form of efaproxiral, a propanoic acid and allosteric modifier of hemoglobin, with radiosensitizing activity. Efaproxiral binds non-covalently to the hemoglobin tetramer, thereby decreasing hemoglobin-oxygen binding affinity. This results in an increase in oxygen levels in hypoxic tumor tissues; increasing tumor oxygenation reduces tumor radioresistance.

Treatment of clinical conditions characterized by tissue hypoxia including cardiovascular, surgical, and critical care conditions; adjunctive treatment in standard radiation therapy and chemotherapy (synthetic allosteric modifier of hemoglobin.

Molecular Weight:363.4
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:6
Exact Mass:363.14465246
Monoisotopic Mass:363.14465246
Topological Polar Surface Area:78.5
Heavy Atom Count:26
Complexity:464
Covalently-Bonded Unit Count:2
Compound Is Canonicalized:Yes