Etazolate
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Etazolate
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CAS No:
51022-77-6
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Formula:
C14H19N5O2
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Chemical Name:
Etazolate
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Synonyms:
1H-Pyrazolo[3,4-b]pyridine-5-carboxylic acid,1-ethyl-4-[2-(1-methylethylidene)hydrazinyl]-,ethyl ester;1H-Pyrazolo[3,4-b]pyridine-5-carboxylic acid,1-ethyl-4-[(1-methylethylidene)hydrazino]-,ethyl ester;1-Ethyl-4-isopropylidenehydrazino-1H-pyrazolo[3,4-b]-1-pyridine-5-carboxylic acid ethyl ester;Etazolate;SQ 64442;1-Ethyl-4-(N′-isopropylidene-hydrazino)-1H-pyrazolo[3,4-b]pyridine-5-carboxylic acid ethyl ester
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CAS No:
Description
Off-White Solid
Etazolate is a pyrazolopyridine that is 1H-pyrazolo[3,4-b]pyridine which is substituted at positions 1, 4, and 5 by ethyl, 2-isopropylidenehydrazino, and ethoxycarbonyl groups, respectively. A phosphodiesterase IV inhibitor with antidepressant and anxiolytic properties. It has a role as a neuroprotective agent, an antipsychotic agent, a phosphodiesterase IV inhibitor, an anxiolytic drug, an antidepressant, an alpha-secretase activator and a GABA agent. It is a hydrazone, an ethyl ester and a pyrazolopyridine.|A potent phosphodiesterase inhibitor proposed as an antipsychotic agent.
Characteristics
81.4
2.50860
white solid
1.25 g/cm3
193-194°C
427.6ºC at 760 mmHg
212.4ºC
1.605
H2O: >20 mg/mL Solutions should be freshly prepared.
Store at RT
Drug Information
Agents that control agitated psychotic behavior, alleviate acute psychotic states, reduce psychotic symptoms, and exert a quieting effect. They are used in SCHIZOPHRENIA; senile dementia; transient psychosis following surgery; or MYOCARDIAL INFARCTION; etc. These drugs are often referred to as neuroleptics alluding to the tendency to produce neurological side effects, but not all antipsychotics are likely to produce such effects. Many of these drugs may also be effective against nausea, emesis, and pruritus. (See all compounds classified as Antipsychotic Agents.)|Compounds which inhibit or antagonize the biosynthesis or actions of phosphodiesterases. (See all compounds classified as Phosphodiesterase Inhibitors.)
Etazolate
Computed Properties
Molecular Weight:289.33
XLogP3:2.1
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:6
Rotatable Bond Count:6
Exact Mass:289.15387487
Monoisotopic Mass:289.15387487
Topological Polar Surface Area:81.4
Heavy Atom Count:21
Complexity:397
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes