2-Methoxy-6-methylaminopyridine
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2-Methoxy-6-methylaminopyridine
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CAS No:
63071-03-4
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Formula:
C7H9NO
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Chemical Name:
2-Methoxy-6-methylaminopyridine
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Synonyms:
2-METHOXY-6-METHYLPYRIDINE;2-METHOXY-6-PICOLINE;6-METHOXY-2-PICOLINE;2-Methoxy-6-methylpyridine 98%;2-Methoxy-6-methylaminopyridine;6-Methoxypicoline;2-Methoxy-6-methylam;Methoxy-6-Methylpyrid
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CAS No:
Characteristics
22.1
1.6
Colorless liquid
1.0±0.1 g/cm3
156/759mm
156°C
1.495
Slightly soluble in water.
Safety Information
Ⅲ
3
1993
20/21/22-36/38-10
26-36/37/39-36/37-23-9
Xi
Irritant
|Warning|H226 (100%): Flammable liquid and vapor [Warning Flammable liquids]|P210, P233, P240, P241, P242, P243, P261, P264, P270, P271, P280, P301+P312, P302+P352, P303+P361+P353, P304+P312, P304+P340, P305+P351+P338, P312, P321, P322, P330, P332+P313, P337+P313, P362, P363, P370+P378, P403+P233, P403+P235, P405, and P501|Aggregated GHS information provided by 7 companies from 4 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.
2-Methoxy-6-methylaminopyridine Use and Manufacturing
Step A. 1) 3-Bromo-2-methoxy-5, 8-dimethyl-6, 7, 8, 9-tetrahydro-5H-pyrido[2, 3-d]azepine A mixture of 2-hydroxy-6-methylpyridine (164 g, 1.47 mol), iodomethane (1.35 kg, 9.53 mol), AgTo a solution of 6-methyl-pyridin-2-ol (2.5 g, 0.023 mol) in CH2CI2 (10 mL) at r. t. , under N2, were added AG2CO3 (6 g, 1.5 eq. ) and Mel (5, 6 mL, 4 eq). The solution was stirred at r. t. for 4 days, then AG2CO3 was filtered and washed with CH2CI2, and the organic layer was evaporated to dryness. The crude product was purified by flash chromatography (silica gel, EtOAc/cHex 2: 8) to give the title compound (1.9 mg, 67percent) as a white solid. NMR (APOS;H, CDCl3) : 8 7.4 (t, 1H), 6.6 (d, 1H), 6.5 (d, 1H), 3.8 (s, 3H), 2.4 (s, 3H).PREPARATION 133
Computed Properties
Molecular Weight:123.15
XLogP3:1.6
Hydrogen Bond Acceptor Count:2
Rotatable Bond Count:1
Exact Mass:123.068413911
Monoisotopic Mass:123.068413911
Topological Polar Surface Area:22.1
Heavy Atom Count:9
Complexity:85
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes
Recommended Suppliers of 2-Methoxy-6-methylaminopyridine
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2 YRS
Business licensedTrader Supplier of pharmaceutical intermediates,excipients,plant extracts,food additives,CDMO,fine cheimcals,Octadecanedioic acid,Eicosanedioic AcidInquiryCAS No.: 63071-03-4Grade: Pharmaceutical GradeContent: 99%
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