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Cetilistat

Cetilistat structure

CAS No:
282526-98-1
Formula:
C25H39NO3
Chemical Name:
Cetilistat
Synonyms:
4H-3,1-Benzoxazin-4-one,2-(hexadecyloxy)-6-methyl-;2-(Hexadecyloxy)-6-methyl-4H-3,1-benzoxazin-4-one;Cetilistat;ATL 962;Cetalstat;2-Hexadecoxy-6-methyl-3,1-benzoxazin-4-one;335149-24-1
Categories:
Pharmaceutical Intermediates > Heterocyclic Compound

Description

Cetilistat is an inhibitor of pancreatic and gastrointestinal lipases. It has great treatment of obesity in both diabetic and non-diabetic patients.

Cetilistat is a benzoxazine.|Cetilistat is a novel inhibitor of pancreatic lipase being developed by Alizyme for the treatment of obesity and associated co-morbidities, including type 2 diabetes.

Cetilistat Basic Attributes

Molecular Weight：

401.582

Exact Mass：

401.58

UNII：

LC5G1JUA39

DSSTox ID：

DTXSID90182506

HScode：

2942000000

Characteristics

PSA：

52.33000

XLogP3：

9.8

Appearance：

Off-white cryst.

Density：

1.0±0.1 g/cm3

Melting Point：

72.0 to 76.0 °C

Boiling Point：

509.7±43.0 °C at 760 mmHg

Flash Point：

158.9±22.6 °C

Refractive Index：

1.521

Vapor Pressure：

0mmHg at 25°C

Drug Information

Drug Indication：

Investigated for use/treatment in obesity.

MeSH：

Agents that increase energy expenditure and weight loss by neural and metabolic regulation. (See all compounds classified as Anti-Obesity Agents.)|Compounds or agents that combine with an enzyme in such a manner as to prevent the normal substrate-enzyme combination and the catalytic reaction. (See all compounds classified as Enzyme Inhibitors.)|Substances that alter the metabolism of LIPIDS. (See all compounds classified as Lipid Regulating Agents.)

Mechanism of Action：

Cetilistat is a gastrointestinal lipase inhibitor that blocks fat digestion and absorption, leading to reduced energy intake, and thus weight loss. It is distinct from most other anti-obesity agents as it does not act on the brain to reduce appetite, but acts peripherally. The compound remains in the gastrointestinal tract with no significant absorption into the body.

MeSH Entry Terms：

2-(hexadecyloxy)-6-methyl-4H-3,1-benzoxazin-4-one

Cetilistat Use and Manufacturing

A novel pancreatic lipase inhibitor for the treatment of obesity in both diabetic and non-diabetic patients.

Computed Properties

Molecular Weight:401.6
XLogP3:9.8
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:16
Exact Mass:401.29299411
Monoisotopic Mass:401.29299411
Topological Polar Surface Area:47.9
Heavy Atom Count:29
Complexity:477
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes

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Guide of Cetilistat

Description
Basic Attributes
Characteristics
Drug Information
Use and Manufacturing
Computed Properties
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