Hydroxychloroquine sulfate
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Hydroxychloroquine sulfate
structure -
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CAS No:
747-36-4
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Formula:
C18H26ClN3O.H2O4S
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Chemical Name:
Hydroxychloroquine sulfate
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Synonyms:
Ethanol,2-[[4-[(7-chloro-4-quinolinyl)amino]pentyl]ethylamino]-,sulfate (1:1);Ethanol,2-[[4-[(7-chloro-4-quinolyl)amino]pentyl]ethylamino]-,sulfate (1:1) (salt);Ethanol,2-[[4-[(7-chloro-4-quinolinyl)amino]pentyl]ethylamino]-,sulfate (1:1) (salt);7-Chloro-4-[4-N-ethyl-N-beta-hydroxyethylamino-1-methylbutylamino]quinoline sulfate;7-Chloro-4-[4-[ethyl(2-hydroxyethyl)amino]-1-methylbutylamino]-quinoline sulfate;Hydroxychloroquine sulfate;Plaquenil sulfate;Plaquenil;Quensyl;Ercoquin;NSC 4375;2-([4-[(7-Chloroquinolin-4-yl)amino]pentyl](ethyl)amino)ethan-1-ol sulfuric acid;2-((4-((7-Chloro-4-quinolyl)amino)pentyl)ethylamino)ethanol sulfate;ZINC 01530654
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CAS No:
Description
Hydroxychloroquine sulfate is a synthetic antimalarial drug which can also inhibit Toll-like receptor 7/9 (TLR7/9) signaling.
A chemotherapeutic agent that acts against erythrocytic forms of malarial parasites. Hydroxychloroquine appears to concentrate in food vacuoles of affected protozoa. It inhibits plasmodial heme polymerase. (From Gilman et al., Goodman and Gilman's The Pharmacological Basis of Therapeutics, 9th ed, p970)
Hydroxychloroquine sulfate Basic Attributes
433.950
433.143829
212-019-3
758663|4375
DTXSID1047811
2933499090
Characteristics
131.37000
4.28400
Odorless Solid
240 °C
516.7ºC at 760 mmHg
266.3ºC
FREELY SOLUBLE
Store in a cool, dry place. Do not store in direct sunlight. Store in a tightly closed container.
178.4 Ų [M+H]+ [CCS Type: TW, Method: calibrated with polyalanine and drug standards]
Safety Information
III
6.1
3276
3
R36/37/38
37/39-26
KK3342500
Xi: Irritant;
P280-P301 + P312 + P330-P305 + P351 + P338-P337 + P313
H302-H319
|Warning|H302 (94.23%): Harmful if swallowed [Warning Acute toxicity, oral]|P261, P264, P270, P271, P272, P280, P301+P312, P302+P352, P304+P340, P305+P351+P338, P312, P321, P330, P332+P313, P333+P313, P337+P313, P362, P363, P403+P233, P405, and P501|Aggregated GHS information provided by 52 companies from 11 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.
Drug Information
Agents used in the treatment of malaria. They are usually classified on the basis of their action against plasmodia at different stages in their life cycle in the human. (From AMA, Drug Evaluations Annual, 1992, p1585) (See all compounds classified as Antimalarials.)|Compounds or agents that combine with an enzyme in such a manner as to prevent the normal substrate-enzyme combination and the catalytic reaction. (See all compounds classified as Enzyme Inhibitors.)|Drugs that are used to treat RHEUMATOID ARTHRITIS. (See all compounds classified as Antirheumatic Agents.)
Hydroxychlorochin
Hydroxychloroquine sulfate Use and Manufacturing
antimalarial, lupus suppressant An antimalarial; antirheumatic; lupus erythematosus suppressant
Human drugs -> Rare disease (orphan)|Human Drugs -> FDA Approved Drug Products with Therapeutic Equivalence Evaluations (Orange Book) -> Active Ingredients
Drug Function and Efficacy
No specific information provided
Registered Holders
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SRINI PHARMACEUTICALS PRIVATE LTD
Active
United States
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MSN LIFE SCIENCES PRIVATE LTD
Active
United States
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ZHUHAI RUNDU PHARMACEUTICAL CO LTD
Active
United States
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