1-[2-(2-Hydroxyethoxy)ethyl]piperazine
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![1-[2-(2-Hydroxyethoxy)ethyl]piperazine structure](https://file.echemi.com/fileManage/upload/canonicalSmiles/20220811/3d4ff8ff9b4a488cae6de17e91e539cb.png "1-[2-(2-Hydroxyethoxy)ethyl]piperazine")
1-[2-(2-Hydroxyethoxy)ethyl]piperazine
structure -
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CAS No:
13349-82-1
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Formula:
C8H18N2O2
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Chemical Name:
1-[2-(2-Hydroxyethoxy)ethyl]piperazine
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Synonyms:
Ethanol,2-[2-(1-piperazinyl)ethoxy]-;2-[2-(1-Piperazinyl)ethoxy]ethanol;N-Hydroxyethoxyethylpiperazine;1-[2-(2-Hydroxyethoxy)ethyl]piperazine;1-[2-[(2-Hydroxyethyl)oxy]ethyl]piperazine;1-((2-Hydroxyethoxy)ethyl)piperazine;2-[2-(Piperazin-1-yl)ethoxy]ethan-1-ol
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CAS No:
1-[2-(2-Hydroxyethoxy)ethyl]piperazine Basic Attributes
174.24
174.24
700-022-7
WWT5E4KNO3
DTXSID60158137
29335990
Characteristics
44.7
-1.2
yellow-brown oil
1.061 g/mL at 25 °C(lit.)
112-114 °C @ Press: 0.25 Torr
>230 °F
n 20/D 1.497(lit.)
7.57E-05mmHg at 25°C
Safety Information
IRRITANT
NONH for all modes of transport
3
R36/37/38
26-37/39
Xi
P261-P305 + P351 + P338
H315-H319-H335
H412 (91.58%): Harmful to aquatic life with long lasting effects [Hazardous to the aquatic environment, long-term hazard]|P273, and P501|Aggregated GHS information provided by 96 companies from 5 notifications to the ECHA C&L Inventory.| |Warning|H315 (100%): Causes skin irritation [Warning Skin corrosion/irritation]|P261, P264, P271, P280, P302+P352, P304+P340, P305+P351+P338, P312, P321, P332+P313, P337+P313, P362, P403+P233, P405, and P501|Aggregated GHS information provided by 46 companies from 5 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.
1-[2-(2-Hydroxyethoxy)ethyl]piperazine Use and Manufacturing
Preparation of 54.2g of compound 3 was added to 300ml of methylene chloride, 26g of trifluoroacetic acid was added and stirred for 2 hours at room temperature.The plate was monitored for complete reaction, and then 1N NaOH aqueous solution was added, stirred for 30 minutes, allowed to stand, and the layers were separated. The organic phase was collected, dried over anhydrous sodium sulfate, and concentrated to give 32.6 g of a colorless liquid, ie piperazine diethylene glycol. Yield: 95 percent.Add 150 kg of 95percent ethanol to the PM-RC-15 reaction tank, stir and open the feed port. Add 200 kg of piperazine bis-salt, 100 kg of piperazine to the reaction tank, dissolve it by heating, add 110 kg of chlorinated diethylene glycol, TheReaction is completed, reduced to 15-20 , centrifugal recovery of piperazine bischloride, the filtrate adjusted to pH 11, filter out sodium chloride, the filtrate vacuum distillation to collect liquid temperature of 154-160 , the top temperature of 145-148 (Yield: 95.1percent) of 90 kg of N- [2- (2-hydroxyethoxy) ethyl] piperazine as a fraction (vacuum: 2 mmHg).100 g (1.2 mol) of anhydrous piperazine and 240 g (1.5 mol) of piperazine dihydrochloride are heated to 120 degrees Celsius, 150 g (1.2 mol) of 2-(2-chloroethoxy)ethanol are added dropwise, and heating and stirring are continued after the addition.The temperature was raised to 136-140 degrees Celsius and held for 1 hour. TLC showed that the reaction was complete and the heating was stopped.When the temperature drops to 80 degrees Celsius, add 500 ml of 95percent ethanol and cool in the refrigerator overnight.The piperazine dihydrochloride was recovered by filtration the next day. The filter cake was washed thoroughly with a small amount of ethanol, and the filtrate was combined.Add 20percent sodium hydroxide solution 200 grams alkalinization, filter out insoluble inorganic salts;After removing the solvent by concentration and distilling off under reduced pressure, collect fractions at 168-172 degrees Celsius/10 mmHg.145 g of 1-[2-(2-hydroxyethoxy)ethyl] is obtained as a colorless to light yellow transparent liquid.Piperazine, yield 70percent, content more than 98percent; there is unknown impurity content in the range of 0.5 to 1percent.
Quetiapine intermediate
Computed Properties
Molecular Weight:174.24
XLogP3:-1.2
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:5
Exact Mass:174.136827821
Monoisotopic Mass:174.136827821
Topological Polar Surface Area:44.7
Heavy Atom Count:12
Complexity:105
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes
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1-[2-(2-Hydroxyethoxy)ethyl]piperazine
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