Fosthiazate

283.34800

283.35

619-377-3

DTXSID0034930

Pale yellow oil|Clear, colorless liquid

29341000

107.02000

3.76940

1.26 g/cm3

<25 °C

198 °C

178.3ºC

1.54

In water, 9.85X10+3 mg/L at 20 deg C

0-6ºC

4.20X10-6 mm Hg at 25 deg C

LD50 in male, female mice, male, female rats (mg/kg): 104, 91, 73, 57 orally; in male, female rats (mg/kg): 2396, 861 dermally. LC50 in male, female rats (mg/l): 0.832, 0.558 by inhalation (Toki).

1.74e-10 atm-m3/mole|Henry's Law constant = 1.76X10-5 Pa-cu m/mol /1.74X10-10 atm-cu m/mol/ at 25 °C

Light gold liquid; BP: 198 °C at 0.5 mm Hg; VP: 2.7X10-6 mm Hg at 25 °C; log Kow = 1.752 /Technical/|Hydroxyl radical reaction rate constant = 8.76X10-11 cu cm/molec sec at 25 °C (est)

III

6.1(b)

UN 2810

3

R21; R23/25; R39; R41; R43; R50/53

S53-S25-S26-S39-S45-S60

TB1707000

T; N

In water, DT50 3 days (pH 9, 25 deg C)

Missing Phrase - N15.00950417-P280-P302 + P352 + P312-P304 + P340 + P312-P305 + P351 + P338 + P310

H301 + H311 + H331-H317-H318-H410

SRP: The most favorable course of action is to use an alternative chemical product with less inherent propensity for occupational harm/injury/toxicity or environmental contamination. Recycle any unused portion of the material for its approved use or return it to the manufacturer or supplier. Ultimate disposal of the chemical must consider: the material's impact on air quality; potential migration in soil or water; effects on animal and plant life; and conformance with environmental and public health regulations.|Contaminated packaging: Empty remaining contents. Triple rinse containers. Empty containers should be taken for local recycling or waste disposal. Do not re-use empty containers. /Nemathorin 10G/|Do not contaminate ponds, waterways or ditches with chemical or used container. Do not dispose of waste into sewer. Where possible recycling is preferred to disposal or incineration. If recycling is not practicable, dispose of in compliance with local regulations. /Nemathorin 10G/|KEEP IN ORIGINAL CONTAINER, tightly closed in a safe place. EMPTY CONTAINER COMPLETELY and dispose of safely. RETURN EMPTY CONTAINER TO YOUR SUPPLIER. DO NOT RE-USE CONTAINER FOR ANY OTHER PURPOSE. /Nemathorin 10G/

USEPA Office of Prevention, Pesticides and Toxic Substances, Pesticide Fact Sheet for Fosthiazate (2004).[Available from, as of June 2, 2011: http://www.epa.gov/opprd001/factsheets/]

|Danger|H301: Toxic if swallowed [Danger Acute toxicity, oral]|P261, P264, P270, P271, P272, P273, P280, P301+P310, P302+P352, P304+P340, P311, P312, P321, P322, P330, P333+P313, P363, P391, P403+P233, P405, and P501|H301 (100%): Toxic if swallowed [Danger Acute toxicity, oral]|P261, P264, P270, P271, P272, P273, P280, P301+P310, P302+P352, P304+P340, P311, P312, P321, P322, P330, P333+P313, P361, P363, P391, P403+P233, P405, and P501|Aggregated GHS information provided by 196 companies from 2 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.|P201, P202, P260, P261, P264, P270, P271, P272, P280, P281, P301+P310, P302+P352, P304+P340, P305+P351+P338, P307+P311, P308+P313, P311, P312, P314, P321, P322, P330, P333+P313, P337+P313, P361, P363, P403+P233, P405, and P501

If airborne dust is generated, use local exhaust ventilation controls. Assess exposure and use any additional measures to keep airborne levels below any relevant exposure limit. Where necessary, seek additional occupational hygiene advice. /Nemathorin 10G/|Chemical-resistant gloves, Protective eyewear.|Chemical resistant gloves should be used. Gloves should be certified to an appropriate standard. Gloves should have a minimum breakthrough time that is appropriate to the duration of exposure. The breakthrough time of gloves varies according to the thickness, material and manufacturer. Gloves should be changed when breakthrough is suspected. Suitable material: nitrile rubber. /Nemathorin 10G/

Special protective equipment for fire fighters: In the event of fire, wear self-contained breathing apparatus. /Nemathorin 10G/|Extinguishing media - small fires: Use water spray, alcohol-resistant foam, dry chemical or carbon dioxide. Extinguishing media - large fires: Use alcohol-resistant foam or water spray. Extinguishing media which must not be used for safety reasons: Do not use a solid water stream as it may scatter and spread fire. /Nemathorin 10G/|Do not allow run-off from fire fighting to enter drains or water courses. Cool closed containers exposed to fire with water spray. /Nemathorin 10G/

This material is capable of forming flammable dust clouds in air, which, if ignited, can produce a dust cloud explosion. Flames, hot surfaces, mechanical sparks and electrostatic discharges can serve as ignition sources for this material. Electrical equipment should be compatible with the flammability characteristics of this material. The flammability characteristics will be made worse if the material contains traces of flammable solvents or is handled in the presence of flammable solvents. /Nemathorin 10G/|As the product contains combustible organic components, fire will produce dense black smoke containing hazardous products of combustion. Exposure to decomposition products may be a hazard to health. /Nemathorin 10G/

WEAR SUITABLE PROTECTIVE CLOTHING (COVERALLS AND RUBBER APRON), SUITABLE PROTECTIVE GLOVES, RUBBER BOOTS, EYE PROTECTION (GOGGLES) AND A FILTERING FACEPIECE RESPIRATOR (DISPOSABLE FILTERING FACEPIECE TO AT LEAST EN 149 FFP3) when cleaning contaminated equipment. /Nemathorin 10G/|Environmental precautions: Do not flush into surface water or sanitary sewer system. Methods for cleaning up: Pick up and arrange disposal without creating dust. Do not create a powder cloud by using a brush or compressed air. Clean contaminated surface thoroughly. ... If the product contaminates rivers and lakes or drains inform respective authorities. /Nemathorin 10G/|Do not contaminate water with the product or its container. Do not clean application equipment near surface water. Avoid contamination via drains from farmyards and roads. /Nemathorin 10G/

SRP: Local exhaust ventilation should be applied wherever there is an incidence of point source emissions or dispersion of regulated contaminants in the work area. Ventilation control of the contaminant as close to its point of generation is both the most economical and safest method to minimize personnel exposure to airborne contaminants. Ensure that the local ventilation moves the contaminant away from the worker.|This material is capable of forming flammable dust clouds in air, which, if ignited, can produce a dust cloud explosion. Flames, hot surfaces, mechanical sparks and electrostatic discharges can serve as ignition sources for this material. Electrical equipment should be compatible with the flammability characteristics of this material. The flammability characteristics will be made worse if the material contains traces of flammable solvents or is handled in the presence of flammable solvents. Avoid contact with skin and eyes. When using, do not eat, drink or smoke. /Nemathorin 10G/|Assess the exposure and select chemical resistant clothing based on the potential for contact and the permeation / penetration characteristics of the clothing material. Wash with soap and water after removing protective clothing. Decontaminate clothing before re-use, or use disposable equipment (suits, aprons, sleeves, boots, etc.). Wear as appropriate: dust impervious protective suit. /Nemathorin 10G/|WEAR SUITABLE PROTECTIVE CLOTHING (COVERALLS) when applying the product via tractor-mounted/drawn machinery. /Nemathorin 10G/|For more Preventive Measures (Complete) data for Fosthiazate (7 total), please visit the HSDB record page.

/AQUATIC SPECIES/ ... In the present study, the stereoisomeric separation and toxicity of fosthiazate, a chiral OP with two asymmetric centers on phosphorus and carbon atoms, was investigated. ... The inhibition potencies of the stereoisomers against acetylcholinesterase of Electrophorus electricus were slightly stereoselective, with a maximum difference of 1.4-fold among the isomers. A 3.1-fold difference, however, was observed in the acute toxicity of isomers to Daphnia magna. The 48-hr toxicity of isomers to D. magna followed the order pk1 > pk2 > pk4 > racemate approximately pk3. The stereoselective toxicity to D. magna found in fosthiazate suggests that the environmental safety of fosthiazate should be evaluated on the basis of its individual isomers.

Fosthiazate's production may result in its release to the environment through various waste streams; its use as a nematicide/insecticide(1) will result in its direct release to the environment(SRC).

TERRESTRIAL FATE: Based on a classification scheme(1), an estimated Koc value of 71(SRC), determined from a log Kow of 1.68(2) and a regression-derived equation(3), indicates that fosthiazate is expected to have high mobility in soil(SRC). Mobility is subject to pH and organic matter content(4). The compound was shown to be more persistent in soils with a pH of <6, exhibiting half-lives ranging from 53.3 to 57.7 days versus 14.1 to 20.7 days for soils with pH >7(5). Volatilization of fosthiazate from moist soil surfaces is not expected to be an important fate process(SRC) given a Henry's Law constant of 1.7X10-10 atm-cu m/mole(2). Fosthiazate is not expected to volatilize from dry soil surfaces(SRC) based upon a vapor pressure of 4.20X10-6 mm Hg at 25 °C(2).|TERRESTRIAL FATE: Under terrestrial field conditions, fosthiazate exhibited a dissipation half-life of 10-17 days. The major soil degradates were methyl sec-butyl sulfone and 2-butanesulfonic acid but these accounted for less than 5% of total applied in field and were present in the surface layer only(1).|AQUATIC FATE: Based on a classification scheme(1), an estimated Koc value of 71(SRC), determined from a log Kow of 1.68(2) and a regression-derived equation(3), indicates that fosthiazate is not expected to adsorb to suspended solids and sediment(SRC). Volatilization from water surfaces is not expected(4) based upon a Henry's Law constant of 1.7X10-10 atm-cu m/mole(2). According to a classification scheme(5), an estimated BCF of 6(SRC), from its log Kow(2) and a regression-derived equation(3), suggests the potential for bioconcentration in aquatic organisms is low(SRC). Photodegradation in water is not an important environmental fate process(6). The compound was shown to be more persistent in soils with a pH of <6, exhibiting half-lives ranging from 53.3 to 57.7 days versus 14.1 to 20.7 days for soils with pH >7(7).|ATMOSPHERIC FATE: According to a model of gas/particle partitioning of semivolatile organic compounds in the atmosphere(1), fosthiazate, which has a vapor pressure of 4.2X10-6 mm Hg at 25 °C(2), will exist in both the vapor and particulate phases in the ambient atmosphere. Vapor-phase fosthiazate is degraded in the atmosphere by reaction with photochemically-produced hydroxyl radicals(SRC); the half-life for this reaction in air is estimated to be 1.5 hours(SRC), calculated from its rate constant of 8.76X10-11 cu cm/molecule-sec at 25 °C(SRC) that was derived using a structure estimation method(3). Particulate-phase fosthiazate may be removed from the air by wet or dry deposition(SRC). Fosthiazate contains chromophores that absorb at wavelengths >290 nm(4), and therefore may be susceptible to direct photolysis by sunlight(SRC).

The rate constant for the vapor-phase reaction of fosthiazate with photochemically-produced hydroxyl radicals has been estimated as 8.76X10-11 cu cm/molecule-sec at 25 °C(SRC) using a structure estimation method(1). This corresponds to an atmospheric half-life of about 1.5 hours at an atmospheric concentration of 5X10+5 hydroxyl radicals per cu cm(1). Fosthiazate exhibits rapid hydrolysis in the environment under alkaline conditions with a half-life of <7 days reported. Under neutral conditions, hydrolysis is slow as suggested by a half-life of 104 days(2). Fosthiazate contains chromophores that absorb at wavelengths >290 nm(3), and therefore may be susceptible to direct photolysis by sunlight(SRC). Photodegradation in water is not an important environmental fate process(2).|Stability in water, half-life = 3 days at pH 9, 50 °C

An estimated BCF of 6 was calculated in fish for fosthiazate(SRC), using a log Kow of 1.68(1) and a regression-derived equation(2). Using a modeling approach based on the quantitative structure-activity relationship (QSAR), a log BCF of 0.50515, corresponding to a BCF of 3 was calculated(3). According to a classification scheme(3), these BCF values suggest the potential for bioconcentration in aquatic organisms is low(SRC).

The Koc of fosthiazate is estimated as 71(SRC), using a log Kow of 1.68(1) and a regression-derived equation(2). According to a classification scheme(3), this estimated Koc value suggests that fosthiazate is expected to have high mobility in soil. The compound is mobile in soil and can leach in acidic soils with low organic matter content as indicated in soil column studies. Using a soil column test employing three orchard soils from Veris, Greece collected in April 2006, fosthiazate was detected in leachates at 0.04, 0.09, and 0.004% of applied on clay (1.77% organic matter, pH 8.10, 37.0% sand, 21.0% silt, 41.0% clay), sandy clay loam (0.49% organic matter, pH 4.80, 57.0% sand, 21.0% silt, 22.0% clay), and clay loam (1.58% organic matter, pH 8.59, 43.0% sand, 19.0% silt, 38.0% clay, respectively. The pH increased with increasing soil depth while organic matter content decreased with increasing soil depth. Dissipation due to biotic and abiotic processes accounted for loss of 97.97%, 94.15%, and 99.62% of applied(4). Freundlich adsorption coefficients (Kd) in three contrasting US soils were determined. Kd values of 0.55 in San Emigdio sandy loam (12% clay, 12.5% sand, 75.4% silt, 0.45% organic matter, pH 7.2), 0.10 in Arlington sandy loam (9% clay, 67% sand, 24% silt, 0.82% organic matter, pH 6.7), and 0.89 in Waukegan clay loam (21% clay, 41% sand, 38% silt, 0.3.1% organic matter, pH 5.5) were measured(5). Freundlich adsorption coefficients of 1.23 to 2.74 mL/g indicate generally weak adsorption and adsorption is shown to be strongly correlated with soil organic matter content(6).

The Henry's Law constant for fosthiazate is 1.32X10-7 atm-cu m/mole(1). This Henry's Law constant indicates that fosthiazate is expected to be essentially nonvolatile from water and moist surfaces(2). Fosthiazate is not expected to volatilize from dry soil surfaces(SRC) based upon a vapor pressure of 4.2X10-6 mm Hg(1).

Fosthiazate was detected at a range of 4.0 to 12.2 ng/g in 4 of 173 samples of Japanese agricultural products (carrots, bananas, grapefruit); limit of detection 1.6 ng/g(1).

Occupational exposure to fosthiazate may occur through inhalation and dermal contact with this compound at workplaces where fosthiazate is produced or used. Limited data indicate that the general population may be exposed to fosthiazate via ingestion of contaminated food. (SRC)

Substances used in the treatment or control of nematode infestations. They are used also in veterinary practice. (See all compounds classified as Antinematodal Agents.)|Chemicals used to destroy pests of any sort. The concept includes fungicides (FUNGICIDES, INDUSTRIAL); INSECTICIDES; RODENTICIDES; etc. (See all compounds classified as Pesticides.)

Groups of 5 Crl:CD BR VAF/Plus rats/sex per group were dosed daily for 14 days by gavage (in 2 mL/kg corn oil vehicle) with fosthiazate at 2 mg/kg. Rats were then administered 2 mg/kg labeled fosthiazate, and were killed after 24 hrs or 168 hrs, at which time tissues (including blood) were collected for radiolabel analyses. Urine, feces, and expired air were collected at intervals after dosing. Unlabeled fosthiazate was 99% pure, and ring-labeled fosthiazate was >99% pure. There was no apparent effect of pre-treatment on metabolism... Patterns of excretion and tissue residues over time were comparable to single dose treatment. Fosthiazate is rapidly absorbed, metabolized, and excreted. Urine was the major route of excretion, whereas feces and expired air were minor routes. Neither sex-related differences in route or rate of excretion were observed. Excretion was essentially complete by 24 hrs after dosing. At 24 hrs, 75 to 82% of administered dose was eliminated. By 168 hrs after termination, 70% and 13.2% of administered dose was excreted in urine and feces, respectively. About 5.3% was eliminated as CO2.|Groups of 5 Crl:CD BR VAF/Plus rats/sex per group were dosed once by gavage (in 2 mL/kg corn oil vehicle) with fosthiazate, either 2 or 20 mg/kg. Unlabeled fosthiazate was 99% pure, and ring-labeled fosthiazate was >99% pure. Excreta and exhaled air were sampled throughout the 7-day post-exposure period. Major tissues were examined at termination for label. Expired air contained 5-6% of administered dose (in 1 N NaOH traps, presumed to be CO2), regardless of sex or dose level. Most of this was collected in the first 12 hrs. Amounts of volatile organics collected downstream from the CO2 traps were minuscule. Urinary metabolites accounted for 66-67% of administered dose in males, and 71- 73% in females. There was no apparent difference between the dose levels. Over one-half of the urinary label was collected within 6 hrs of dosing in all cases. Fecal metabolites constituted 11-12% of administered dose, regardless of sex or dose. Most of this label was collected within 48 hrs. Total percentage of administered dose found in all body tissues combined were 11.0 and 9.4% in 2 mg/kg/day and 20 mg/kg/day males, respectively; and 8.2 and 6.8% in respective females, suggesting appreciable retention. Tissue label was widely distributed at 1 week post-treatment. Highest concentrations of label at 2 mg/kg were in liver, lung, and heart. Radioactivity was clearly not concentrated in points of entry (g.i. tract) or circulation (blood), nor in the fat. This appreciable tissue retention, coupled with the significant CO2 production of labeled carbon from metabolism of the ring component, suggests that carbon from the thiazolidinyl ring is substantially assimilated into the body's carbon pool. ...|Ten Crl:CD BR VAF/Plus rats/sex/group were dosed once daily by gavage (in 2 mL/kg corn oil vehicle) with unlabeled fosthiazate at 2 mg/kg/day. On Day 15, rats were administered 2 mg/kg S-sec-butyl-labeled fosthiazate. Five/sex were sacrificed at 24 hr after dosing with label: the other 5/sex were sacrificed after 7 days. ... There was no apparent effect of the pre-treatment on distribution and excretion patterns. Fate of label in the 7-day rats in this study in percent of administered dose was: urine (73 and 74% in M and F, respectively), feces (8 and 9% in M and F), expired air as CO2 (9 and 8% in M and F), expired air as volatile organics (0.5 and 0.6% in M and F), and all tissues combined (1.8 and 1.2% in M and F). ... no sampled organ had specific radioactivity higher than 2x that of whole blood at day 7 sacrifice. Tissue sampling at 24-hr sacrifice (excluding g.i. tract, due to insufficient time for normal passage of labeled lumenal contents) found liver to have the highest specific radioactivity relative to whole blood (liver/blood ratio 4.4 in M and 2.3 in F), followed by lung (lung/blood ratio 2.0 in M and 1.6 in F), with kidney and adrenal specific concentrations slightly lower than lung, and most organs or tissues similar to or lower label concentration than whole blood. ...

Groups of 7 Crl:CD BR VAF/Plus rats/sex were dosed once by gavage (in 2.5 mL/kg corn oil vehicle) with fosthiazate at 18 mg/kg. Non-radiolabeled fosthiazate, which contained 13C on 50% of each of the methyl carbons of the butyl group, was 99.3% pure. S-sec-butyl-2-14C-labeled fosthiazate was 97.7% pure (by MS). Investigators evaluated fate of fosthiazate in tissues and excreta over 48 hrs, and characterized major metabolites found in urine. S-sec-butyl-2-14C-labeled group in the present study produced about the same distribution of label in excreta as had been observed in /another study/ which utilized ring-labeled 14C. This suggests that both the ring and the butyl substituents undergo degradation to release appreciable CO2 (about 10% of administered dose). Identified large MW metabolites (excluding glutathione products) underwent ring opening, often with subsequent methylation of the ring sulfur. Products of oxidation of this ring sulfur, such as sulfonic acids, sulfoxides, and sulfones, constituted about 20% of administered dose. There were several observed residues of hydrolysis of the S-sec-butyl group, similarly displaying oxidation of the sulfur, with or without methylation of the sulfur. Some of the S-secbutyl group residues underwent glutathione conjugation and were manifest as N-acetyl cysteine products (not further characterized). ...|Seven Crl:CD BR VAF/Plus rats/sex were dosed once by gavage (in 2.2 mL/kg corn oil) with 22 mg/kg ring-14C-fosthiazate prior to ... identifying major metabolites. ... Nine peaks /were observed/ migrating near to the solvent front formed the largest cluster of radio-labeled components, none of which were characterized. They were considered to be small, polar, and apparently uncharged based on their mobility on a reverse-phase HPLC column and the minimal influence of a basic ion-pairing agent on their mobilities. These constituted 42% of administered dose in males, and 27% of administered dose in females. It appears that ring carbons were substantially assimilated into the carbon pool, considering together the appreciable labeled CO2 output, substantial label retention in tissues, and the presence of many small MW labeled components in urine. Three metabolites retained the S-butyl substituent and underwent opening of the thiazolidinyl ring. Together these constituted about 7% of administered label in males and 18% in females. The most abundant of these was (RS)-S-sec-butyl O-ethyl N-(2-methylsulfinylethyl) phosphoramidothioate (designated BESxP). A couple of analogous metabolites had undergone loss of the S-sec-butyl group; O-ethyl S-hydrogen N-2(methylsulfonyl)ethyl phosphoramidothioate (DBSoS) in particular (4.6% of administered dose in males, and 3.0% in females). Acetamide (a rat liver carcinogen at levels about 1000 x larger than levels observed in this study) constituted 3% and 2% of administered dose in males and females, respectively. ...

Groups of 5 Crl:CD BR VAF/Plus rats/sex per group were dosed once by gavage (in 2 mL/kg corn oil vehicle) with fosthiazate, either 2 or 20 mg/kg. Unlabeled fosthiazate was 99% pure, and ringlabeled fosthiazate was >99% pure. ... Median initial half-life estimates (defined as peak blood concentration time to 12 hrs post-dosing) were 14.9 or 11.5 hrs for low dose males and females, respectively. High dose initial half-life estimates were 8.6 hrs for both males and females. Median half-life values for the later phase of 18 to 168 hrs were 76 and 66 hrs for 2 mg/kg males and females, respectively; and 92 and 87 hrs for 20 mg/kg males and females, respectively. ...

/SRP:/ Immediate first aid: Ensure that adequate decontamination has been carried out. If patient is not breathing, start artificial respiration, preferably with a demand valve resuscitator, bag-valve-mask device, or pocket mask, as trained. Perform CPR if necessary. Immediately flush contaminated eyes with gently flowing water. Do not induce vomiting. If vomiting occurs, lean patient forward or place on the left side (head-down position, if possible) to maintain an open airway and prevent aspiration. Keep patient quiet and maintain normal body temperature. Obtain medical attention. /Poisons A and B/|/SRP:/ Basic treatment: Establish a patent airway (oropharyngeal or nasopharyngeal airway, if needed). Suction if necessary. Watch for signs of respiratory insufficiency and assist ventilations if needed. Administer oxygen by nonrebreather mask at 10 to 15 L/min. Monitor for pulmonary edema and treat if necessary ... . Monitor for shock and treat if necessary ... . Anticipate seizures and treat if necessary ... . For eye contamination, flush eyes immediately with water. Irrigate each eye continuously with 0.9% saline (NS) during transport ... . Do not use emetics. For ingestion, rinse mouth and administer 5 mL/kg up to 200 mL of water for dilution if the patient can swallow, has a strong gag reflex, and does not drool ... . Cover skin burns with dry sterile dressings after decontamination ... . /Poisons A and B/|/SRP:/ Advanced treatment: Consider orotracheal or nasotracheal intubation for airway control in the patient who is unconscious, has severe pulmonary edema, or is in severe respiratory distress. Positive-pressure ventilation techniques with a bag valve mask device may be beneficial. Consider drug therapy for pulmonary edema ... . Consider administering a beta agonist such as albuterol for severe bronchospasm ... . Monitor cardiac rhythm and treat arrhythmias as necessary ... . Start IV administration of D5W /SRP: "To keep open", minimal flow rate/. Use 0.9% saline (NS) or lactated Ringer's if signs of hypovolemia are present. For hypotension with signs of hypovolemia, administer fluid cautiously. Watch for signs of fluid overload ... . Treat seizures with diazepam or lorazepam ... . Use proparacaine hydrochloride to assist eye irrigation ... . /Poisons A and B/

(RS)-S-sec-butyl-O-ethyl-2-oxo-1,3-thiazolidin-3-ylphosphonothioate

Granule|Formulations: 96.0% a.i. technical product; 75.0% a.i. emulsifiable concentrate end-use product; 50% a.i. emulsifiable concentrate end-use product.|Fosthiazate 900EC (Isk Biosciences Corporation) Fosthiazate 75%|Nemathorin 500EC (Isk Biosciences Corporation) Fosthiazate 47.2%|For more Formulations/Preparations (Complete) data for Fosthiazate (6 total), please visit the HSDB record page.

... The inhibition potencies of the stereoisomers against acetylcholinesterase of Electrophorus electricus were slightly stereoselective, with a maximum difference of 1.4-fold among the isomers. A 3.1-fold difference, however, was observed in the acute toxicity of isomers to Daphnia magna. The 48-hr toxicity of isomers to D. magna followed the order pk1 > pk2 > pk4 > racemate approximately pk3. The stereoselective toxicity to D. magna found in fosthiazate suggests that the environmental safety of fosthiazate should be evaluated on the basis of its individual isomers.

Agrochemicals -> Nematicides