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(+)-Dioscin

(+)-Dioscin structure

CAS No:
19057-60-4
Formula:
C45H72O16
Chemical Name:
(+)-Dioscin
Synonyms:
β-D-Glucopyranoside,(3β,25R)-spirost-5-en-3-yl O-6-deoxy-α-L-mannopyranosyl-(1→2)-O-[6-deoxy-α-L-mannopyranosyl-(1→4)]-;Dioscin;(3β,25R)-Spirost-5-en-3-yl O-6-deoxy-α-L-mannopyranosyl-(1→2)-O-[6-deoxy-α-L-mannopyranosyl-(1→4)]-β-D-glucopyranoside;Dioscine;Diosgenin bis-α-L-rhamnopyranosyl-(1→2 and 1→4)-β-D-glucopyranoside;Collettiside III;(+)-Dioscin;Polyphyllin III;Diosgenin 3-O-α-L-rhamnopyranosyl-(1→4)-[α-L-rhamnopyranosyl-(1→2)]-β-D-glucopyranoside;3-O-β-D-α-L-Rhamnopyranosyl(1→4)-[α-L-rhamnopyranosyl(1→2)]-β-D-glucopyranoside-diosgenin;Diosgenin 3-O-α-L-rhamnopyranosyl-(1→2)-[α-L-rhamnopyranosyl-(1→4)]-β-D-glucopyranoside;Paris III;Parissaponin III;1380-39-8
Categories:
Active Pharmaceutical Ingredients > Circulatory System Drugs

Description

Dioscin(CCRIS 4123; Collettiside III) is a natural steroid saponin derived from several plants, showing potent anti-cancer effect against a variety of tumor cell lines. IC50 value:Target: Anticancer agentin vitro: dioscin (1, 2 and 4 μmol/L) could significantly inhibit the viability of LNCaP cells in a time- and concentration-dependent manner. Flow cytometry revealed that the apoptosis rate was increased after treatment of LNCaP cells with dioscin for 24 h, indicating that apoptosis was

Dioscin is a spirostanyl glycoside that consists of the trisaccharide alpha-L-Rha-(1->4)-[alpha-L-Rha-(1->2)]-beta-D-Glc attached to position 3 of diosgenin via a glycosidic linkage. It has a role as a metabolite, an antifungal agent, an antiviral agent, an antineoplastic agent, an anti-inflammatory agent, a hepatoprotective agent, an apoptosis inducer and an EC 1.14.18.1 (tyrosinase) inhibitor. It is a spirostanyl glycoside, a spiroketal, a hexacyclic triterpenoid and a trisaccharide derivative. It derives from a diosgenin. It derives from a hydride of a spirostan.

(+)-Dioscin Basic Attributes

Molecular Weight：

869.04

Exact Mass：

869.04

UNII：

3B95U4OLWV

HScode：

29389090

Characteristics

PSA：

236

XLogP3：

1.3

Density：

1.39±0.1 g/cm3(Predicted)

Melting Point：

288 °C (decomp)

Refractive Index：

1.614

Safety Information

safety instructions：

24/25

Drug Information

MeSH Entry Terms：

dioscin

(+)-Dioscin Use and Manufacturing

Dioscin, a natural steroid saponin that has been shown to promote anticancer activity against several forms of cancers. Dioscin induces cancer cell apoptosis through elevated oxidative stress mediated by downregulation of peroxiredoxins.

Computed Properties

Molecular Weight:869.0
XLogP3:1.3
Hydrogen Bond Donor Count:8
Hydrogen Bond Acceptor Count:16
Rotatable Bond Count:7
Exact Mass:868.48203620
Monoisotopic Mass:868.48203620
Topological Polar Surface Area:236
Heavy Atom Count:61
Complexity:1600
Defined Atom Stereocenter Count:26
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes

Drug Function and Efficacy

Extract from the above information

This ingredient has been used in drugs with the following functions (note: it does not mean that the ingredient itself has the following health functions)

Related Drugs

Dioscin

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