Ethylene oxide-propylene oxide copolymer

102.1317

304.115814

618-355-0

63908

DTXSID70872897|DTXSID4047597

Liquid

39059100

25.06000

0.00

APHA: ≤120, 50/50 in CH3OH solution

1.2±0.1 g/cm3

56 °C

>200 °C(lit.)

>230 °F

1.452

Miscible with water.

2-8°C

<0.3 mm Hg ( 20 °C)

>1 (vs air)

LD50 oral in rabbit: 35gm/kg

Vary from water-insoluble to very water-soluble compounds /Poloxamers/

NONH for all modes of transport

3

21-23/24/25-25-36/37/38

23-24/25-45-36/37/39-26

TP6164333

T

P261, P271, P304+P312, P304+P340, P312

H332

SRP: The most favorable course of action is to use an alternative chemical product with less inherent propensity for occupational exposure or environmental contamination. Recycle any unused portion of the material for its approved use or return it to the manufacturer or supplier. Ultimate disposal of the chemical must consider: the material's impact on air quality; potential migration in soil or water; effects on animal, aquatic, and plant life; and conformance with environmental and public health regulations.

Oral dosage form new animal drugs: Poloxalene. (a) Specifications. Polyoxypropylene-polyoxyethylene glycol nonionic block polymer. ... Conditions of use. (1) For treatment of legume (alfalfa, clover) bloat in cattle. (2) For control of legume (alfalfa, clover) bloat in cattle. (3) For prevention of legume (alfalfa, clover) and wheat pasture bloat in cattle. (4) For control of legume (alfalfa, clover) and wheat pasture bloat in cattle.|New animal drugs for use in animal feeds: Poloxalene. (a) Approvals. (1) Dry Type A medicated articles: 53 percent to 000069 in 510.600(c) of this chapter. (2) Liquid Type A medicated articles: 99.5 percent to 000069 in 510.600(c) of this chapter. (b) Conditions of use. (1) For prevention of legume (alfalfa, clover) and wheat pasture bloat in cattle.|New animal drugs for use in animal feeds: Poloxalene free-choice liquid Type C feed. (a) Approvals. Type A medicated articles: 99.5 percent to 066104 in 510.600(c) of this chapter. (b) Conditions of use. (1) For control of legume (alfalfa, clover) and wheat pasture bloat in cattle ... (2) For control of legume (alfalfa, clover) bloat in cattle grazing of prebloom legumes.|Poloxalene is a food additive permitted in feed and drinking water of animals.

|Warning|H332 (100%): Harmful if inhaled [Warning Acute toxicity, inhalation]|P261, P271, P304+P312, P304+P340, and P312|Aggregated GHS information provided by 57 companies from 3 notifications to the ECHA C&L Inventory.

Mechanical cleansing of a wound with a sponge soaked in a surfactant has prevented the development of experimental wound infection. The surfactant utilized for wound cleansing is Pluronic F-68 (poloxalene; I), a member of a family of block copolymers called Pluronic polyls. Long term toxicity studies and clinical trials suggest that this surfactant is safe for human use. I is a nonionic detergent that does not have any intrinsic antibacterial activity. Although mechanical cleansing with saline-soaked sponges effectively removes bacteria, it damages the wound and impairs its resistance to infection. The severity of the damage to the skin exerted by the sponge can be correlated with its porosity. Sponges with a low porosity are abrasive and exert more damage to skin than do sponges with a higher porosity. The addition of I to even the most abrasive sponges ensures that the bacterial removal efficiency of the sponge scrub is maintained, while tissue trauma is minimized. This dual effect of the surfactant results in a dramatic reduction in the infection rate of contaminated wounds.|(VET): Prevention of bloat in cattle.

A randomized, double blind, placebo controlled, dose escalation study of the toxicity and pharmacokinetics of poloxamer 188 (RheothRx) was conducted in 36 healthy male subjects (ages 19-35 yr) who received iv injections of 10-90 mg/kg/hr poloxamer or placebo. ... The most common adverse effects were pain, injection site abnormality, and nausea. Eight subjects discontinued treatment with poloxamer due to adverse events.

Agents that modify interfacial tension of water; usually substances that have one lipophilic and one hydrophilic group in the molecule; includes soaps, detergents, emulsifiers, dispersing and wetting agents, and several groups of antiseptics. (See all compounds classified as Surface-Active Agents.)|Agents that are used to stimulate evacuation of the bowels. (See all compounds classified as Cathartics.)|Substances used on inanimate objects that destroy harmful microorganisms or inhibit their activity. Disinfectants are classed as complete, destroying SPORES as well as vegetative forms of microorganisms, or incomplete, destroying only vegetative forms of the organisms. They are distinguished from ANTISEPTICS, which are local anti-infective agents used on humans and other animals. (From Hawley's Condensed Chemical Dictionary, 11th ed) (See all compounds classified as Disinfectants.)

Absorption and excretion of 14C-Poloxalene 2930 (PX), a nonionic hydrophobic surfactant of large molecular weight, were studied using bile fistula rats. Approximately half of the dose infused intraduodenally was absorbed and some of the absorbed surfactant was excreted in bile. The remainder was excreted in urine. Only trace quantities of the 14C-PX were recovered in liver and carcass at termination of the study. Two studies were also performed with 14C-PX incorporated into the diet. In the first feeding study of 7 days duration, most of the agent was excreted via the gastrointestinal tract within 72 hr of discontinuing treatment. In the second study, rats were fed dietary 14C-PX for 7, 14, or 23 days to determine whether the surfactant continued to accumulate in the body as the test period was extended. Further accumulation did occur between the 7th and 14th days but not when feeding was continued for a total of 23 days. Of the amount of 14C-PX ingested after 23 days of feeding, essentially all was excreted by the end of 7 days after discontinuing treatment. These studies indicate that despite its large molecular weight of about 3,000 some 14C-PX is absorbed. Furthermore, absorbed material is promptly excreted in bile and urine with little retained in body tissues.|To investigate the distribution of poloxamer 407 (Pluronic F-127), rats received 300 mg of intraperitoneal poloxamer 407 solution; blood and urine samples were taken frequently and liver and kidney homogenates were prepared and analyzed using a colorimetry assay. Clearance was 0.014 mL/min. The mean amount excreted in the urine was 76.3 mg in 24 hr. Amounts of poloxamer 407 in supernatants of liver and kidney homogenates were 15.9 and 3.1 mg, respectively.|...The disposition and pharmacokinetics of Poloxamer 108 was studied in rats as an initial step towards understanding its behavior in man. After iv administration in rats, about 94% of 7 or 100 mg/kg doses of ethylene-14-C-labeled polymer was excreted in the urine in 3 days. About 6% of the label appeared in feces. Erythrocyte membranes were not permeable to the polymer, and only the parent compound was demonstrable in urine. Twenty hours after dosing, small residues were detectable only in the kidney, liver, small intestine and carcass. The 3rd phase of the plasma disappearance pattern was evident only at the larger dose, but plasma disappearance kinetics were independent of the dose in the used range. Most of Poloxamer 108 was eliminated rapidly in rats by renal excretion; a smaller portion probably was removed by biliary excretion.|A randomized, double blind, placebo controlled, dose escalation study of the toxicity and pharmacokinetics of poloxamer 188 (RheothRx) was conducted in 36 healthy male subjects (ages 19-35 yr) who received iv injections of 10-90 mg/kg/hr poloxamer or placebo. Poloxamer was eliminated primarily by renal excretion. Estimates of clearance, elimination rate constant, and apparent volume of distribution at steady state were independent of infusion rate. Steady state plasma levels increased linearly with increasing infusion rate values up to 90 mg/kg/hr. Mean plasma clearance was 1.06 mL/min/kg. ...

Bloat Guard

Trade names: Bloat Guard; Therabloat|A block polymer of ethylene oxide and propylene oxide... .

Analyte: poloxalene; matrix: chemical identification; procedure: visual reaction (blue color) with ammonium thiocyanate, cobalt nitrate and ethylene chloride|Analyte: poloxalene; matrix: chemical purity; procedure: ultraviolet absorption spectrophotometry with detection at 630 nm and comparison to standards

EPA Safer Chemical Functional Use Classes -> Defoamers;Surfactants|Safer Chemical Classes -> Green circle - The chemical has been verified to be of low concern|Animal Drugs -> FDA Approved Animal Drug Products (Green Book) -> Active Ingredients|Cosmetics -> Emulsifying; Surfactant