 Home > Encyclopedia > Bifonazole

Bifonazole

Bifonazole structure

CAS No:
60628-96-8
Formula:
C22H18N2
Chemical Name:
Bifonazole
Synonyms:
1H-Imidazole,1-([1,1′-biphenyl]-4-ylphenylmethyl)-;1-([1,1′-Biphenyl]-4-ylphenylmethyl)-1H-imidazole;Trifonazole;Bifonazole;BAY-h 4502;Mycospor;Bifazol;(±)-Bifonazole;Mycosporan;Amycor;Bedriol;Azolmen;A-One-L;Bicutrin;bifosin;Agispor;1-[Phenyl(4-phenylphenyl)methyl]-1H-imidazole;1-[Phenyl-(4-phenylphenyl)methyl]imidazole;1-(Biphenyl-4-yl-phenyl-methyl)-1H-imidazole;162824-44-4
Categories:
Cosmetic Ingredient > Anti-seborrheic

Description

Bifonazole is an imidazole antifungal drug.Target: AntifungalBifonazole, a new broad-spectrum antimycotic, interferes with sterol biosynthesis. In dermatophytes bifonazole additionally inhibits directly HMG-CoA-reductase. bifonazole possesses a sequential mode of action, namely inhibition of cytochrome P450-dependent C14-demethylation of sterols and direct inhibition of HMG-CoA-reductase. In vitro bifonazole shows a strongly pH-dependent efficacy. The uptake kinetics of bifonazole have b

Solid

1-[biphenyl-4-yl(phenyl)methyl]imidazole is a member of the class of imidazoles carrying an alpha-(biphenyl-4-yl)benzyl substituent at position 1. It is a member of imidazoles and a member of biphenyls.|Bifonazole is an azole antifungal drug.

Bifonazole Basic Attributes

Molecular Weight：

310.39

Exact Mass：

310.39

EC Number：

262-336-6

NSC Number：

758954

DSSTox ID：

DTXSID9045631

ATC Code：

D01AC10|D - Dermatologicals

HScode：

2933290090

Characteristics

PSA：

17.8

XLogP3：

4.8

Appearance：

white to off-white

Density：

1.1±0.1 g/cm3

Melting Point：

142 °C

Boiling Point：

491.7°C at 760 mmHg

Flash Point：

251.2±22.9 °C

Refractive Index：

1.616

Water Solubility：

soluble in DMSO

Storage Conditions：

room temp

Toxicity：

Oral-rat LD50; 1463 mg/kg; Oral-Mouse LD50; 2629 mg/kg

Flammability characteristics：

Flammable; burning produces toxic nitrogen oxide fumes

Collision Cross Section：

184.8 Å² [M+H]+ [CCS Type: TW, Method: calibrated with polyalanine and drug standards]

Safety Information

Transport codes：

NONH for all modes of transport

wgk germany：

hazard class code：

RTECS Number：

NI3517000

Marks：

Storage features：

Ventilated, low temperature and dry

Precautionary statement(s)：

P301 + P312 + P330

Hazard Statements：

H302

GHS Classification：

|Warning|H302 (100%): Harmful if swallowed [Warning Acute toxicity, oral]|P264, P270, P301+P312, P330, and P501|Aggregated GHS information provided by 198 companies from 3 notifications to the ECHA C&L Inventory.

Toxicity

Toxicity class：

moderately toxic

Drug Information

Drug Indication：

Used for the treatment of various topical fungal infections, including athlete's foot (tinea pedis).

Pharmacology：

Bifonazole is a type of antifungal medicine known as an imidazole. It kills fungi and yeasts by interfering with their cell membranes.

MeSH：

Substances that destroy fungi by suppressing their ability to grow or reproduce. They differ from FUNGICIDES, INDUSTRIAL because they defend against fungi present in human or animal tissues. (See all compounds classified as Antifungal Agents.)

Absorption：

Very low absorption following topical administration (0.6% of an applied dose). In cases of skin lesions absorption is increased (2.5%).

Metabolism/Metabolites：

Hepatic.

Biological Half-Life：

1-2 hours

Mechanism of Action：

Bifonazole works by inhibiting the production of a substance called ergosterol, which is an essential component of fungal cell membranes.It acts to destabilize the fungal cyctochrome p450 51 enzyme (also known as Lanosterol 14-alpha demethylase). This is vital in the cell membrance structure of the fungus. Its inhibition leads to cell lysis. The disruption in production of ergosterol disrupts the cell membrane and causes holes to appear. The cell membranes of fungi are vital for their survival. They keep unwanted substances from entering the cells and stop the contents of the cells from leaking out. As bifonazole causes holes to appear in the cell membranes, essential constituents of the fungal cells can leak out. This kills the fungi.

MeSH Entry Terms：

1-((4-biphenylyl)-phenylmethyl)-1H-imidazole

Bifonazole Use and Manufacturing

antibacterial

Computed Properties

Molecular Weight:310.4
XLogP3:4.8
Hydrogen Bond Acceptor Count:1
Rotatable Bond Count:4
Exact Mass:310.146998583
Monoisotopic Mass:310.146998583
Topological Polar Surface Area:17.8
Heavy Atom Count:24
Complexity:362
Undefined Atom Stereocenter Count:1
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes

Drug Function and Efficacy

This product is a broad-spectrum antifungal drug. Its mechanism of action is to inhibit the synthesis of cell membranes. It has antibacterial effects on dermatophytes and Candida.

This ingredient has been used in drugs with the following functions (note: it does not mean that the ingredient itself has the following health functions)

Related Drugs

Bifonazole cream
Ingredients	Each gram of this product contains 10 mg of the main ingredient bifonazole, and the auxiliary materials are stearic acid, glyceryl monostearate, octadecyl alcohol, cetyl alcohol, Span 60, propylene glycol, glycerin, emulsified silicone oil, potassium lauryl phosphate, Germa A, and purified water.
Indication	If you are using other medicines, please consult your physician or pharmacist before using this product.
Specifications	15g:150mg
Manufacturer	Hainan Quanxing Pharmaceutical Co., Ltd.

Bifonazole cream
Ingredients	Each gram of this product contains 10 mg of the main ingredient bifonazole, and the auxiliary materials are stearic acid, glyceryl monostearate, octadecyl alcohol, cetyl alcohol, Span 60, propylene glycol, glycerin, emulsified silicone oil, potassium lauryl phosphate, Germa A, and purified water.
Indication	If you are using other medicines, please consult your physician or pharmacist before using this product.
Specifications	1%
Manufacturer	Xi'an Lantai Pharmaceutical Co., Ltd.

Bifonazole cream
Ingredients	Each gram of this product contains 10 mg of the main ingredient bifonazole, and the auxiliary materials are stearic acid, glyceryl monostearate, octadecyl alcohol, cetyl alcohol, Span 60, propylene glycol, glycerin, emulsified silicone oil, potassium lauryl phosphate, Germa A, and purified water.
Indication	Not yet clear.
Specifications	15g:150mg
Manufacturer	Anhui Hongsanqi Pharmaceutical Co., Ltd.

See More Related Drugs

Registered Holders

Chongqing Qingyang Pharmaceutical Co., Ltd.

China
Active
Jiangsu Sinopep-Allsino Biopharmaceutical Co., Ltd.

China
Active
Zhongshan Wanhan Pharmaceuticals Co., Ltd.

China
Active

See More Registered Holders

Recommended Suppliers of Bifonazole

chemtour Contact Supplier

CN
5 YRS

Business licensed

Trader Supplier of amino acid derivatives,pharmaceutical intermediates,oligonucleotide reagent

Bifonazole-

CAS No.: 60628-96-8

Grade: Pharmaceutical Grade

Content: 98%

Inquiry
HANGZHOU LEAP CHEM CO., LTD. Contact Supplier

CN
5 YRS

Business licensed

Trader Supplier of Intermediates,Building blocks,API,Silicones,Peptides,Lab chemicals,Biochemicals,Pharmaceuticals,Screening Compounds,Food Additives

Bifonazole

CAS No.: 60628-96-8

Content: 99.00%

Inquiry
Shanghai Lonwin Chemical Co.,Ltd Contact Supplier

CN
3 YRS

Business licensed

Trader Supplier of CHEMICALS,REAGENTS

Factory Supply Bifonazole CAS NO.60628-96-8

CAS No.: 60628-96-8

Grade: Pharmaceutical Grade

Content: 99%

Inquiry
ChemExpress Contact Supplier

CN
3 YRS

Business licensed Certified factory

Manufactory Supplier of CRO

60628-96-8 | ChemExpress

CAS No.: 60628-96-8

Inquiry

Learn More Other Chemicals

Pyrithione zinc

13463-41-7
Sodium dihydrogen phosphate dihydrate

13472-35-0
Monosodium phosphate

7558-80-7
Shikimic acid Formula

138-59-0
Capryloylglycine Formula

14246-53-8
Myramistin Formula

15809-19-5
Ginsenoside Rh4 Structure

174721-08-5
(3S,4R,5S)-4-Hydroxy-5-methoxy-4-[(2S,3R)-2-methyl-3-(3-methyl-2-buten-1-yl)-2-oxiranyl]-1-oxaspiro[2.5]octan-6-one Structure

19683-98-8
What is Clotrimazole

23593-75-1
What is N,N-Bis(2-hydroxyethyl)undecenamide

25377-64-4

Hot Searches: dinitrogen trioxide formula; disodium pyrophosphate; hcl sds; magnesium phosphate formula; nicotine patch drug class; strem chemicals

Guide of Bifonazole

Description
Basic Attributes
Characteristics
Safety Information
Toxicity
Drug Information
Use and Manufacturing
Computed Properties
Drug Function and Efficacy
Related Drugs
Registered Holders
Recommended Suppliers
Learn More Other Chemicals

Bifonazole

SDS

Request for Quotation



Feedback & Suggestions

Send Message

Thank you for your feedback. If you require further assistance, please contact us by email at info@echemi.com or call us at +86-532-55729510.