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Ciprofloxacin lactate

Ciprofloxacin lactate structure

CAS No:
97867-33-9
Formula:
C20H24FN3O6
Chemical Name:
Ciprofloxacin lactate
Synonyms:
1-cyclopropyl-6-fluoro-1,4-dihydro-4-oxo-7-(1-piperazinyl)-3-quinolinecarboxylic acid lactate;CIPROFLOXACIN LACTATE;mono(2-hydroxypropanoate);Ciprofloxacin lactate CP2000;Ciprofloxacine lactate;CIPROFLOXACIN-QACID;CIPROFLOXACIN LACTAT;1-cyclopropyl-6-fluoro-4-oxo-7-piperazin-1-ylquinoline-3-carboxylic acid,2-hydroxypropanoic acid
Categories:
Active Pharmaceutical Ingredients > Synthetic Anti-infective Drugs

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Ciprofloxacin lactate Basic Attributes

Molecular Weight：

421.43

Exact Mass：

403.154358

EC Number：

1806241-263-5

Color/Form：

White to Off-White

HScode：

29339900

Characteristics

PSA：

130

XLogP3：

1.34310

Appearance：

White or yellow crystalline powder

Density：

1.4±0.1 g/cm3

Melting Point：

255-257°C

Boiling Point：

581.8°C at 760 mmHg

Flash Point：

350.8±31.5 °C

Refractive Index：

1.624

Critical Temperature & Pressure：

Inert atmosphere,Room Temperature

Safety Information

safety instructions：

24/25

Ciprofloxacin lactate Use and Manufacturing

The new broad-spectrum antibacterial drug has strong permeability, high blood concentration, low toxicity, is not easy to produce drug resistance, and can be quickly distributed to other organs. This medicine is easily absorbed by oral administration and has better effect of intramuscular injection. The new quinolones broad-spectrum antibacterial drugs have a strong effect on Gram-positive and negative bacteria.

Ciprofloxacin Lactate is an antibiotic that has been used to medicate polymer wound dressing. Ciprofloxacin Lactate has been shown to produce high and sustained serum bactericidal titers against highly susceptible bacteria.

Drug Function and Efficacy

This product has a broad-spectrum antibacterial effect, especially high antibacterial activity against aerobic Gram-negative bacilli. It has good antibacterial activity against the following bacteria in vitro: most bacteria of the Enterobacteriaceae family, including Citrobacter, Enterobacter cloacae, Enterobacter aerogenes, Escherichia coli, Klebsiella, Proteus, Salmonella, Shigella, Vibrio, Yersinia, etc. It often has antibacterial activity against multi-drug resistant bacteria. It has high antibacterial activity against penicillin-resistant Neisseria gonorrhoeae, enzyme-producing influenza bacilli and Moraxella. It has no antibacterial activity against aeruginosa. It has antibacterial activity against most strains of Pseudomonas, such as Pseudomonas. It has antibacterial activity against methicillin-sensitive Staphylococci, and only moderate antibacterial activity against Streptococcus pneumoniae, hemolytic Streptococcus, and Enterococcus faecalis. It has good antimicrobial activity against Chlamydia trachomatis, Mycoplasma, and Legionella, and also has antibacterial activity against Mycobacterium tuberculosis and atypical mycobacteria. It has poor antibacterial activity against anaerobic bacteria. Ciprofloxacin is a bactericide that acts on the A subunit of bacterial DNA helicase, inhibiting DNA synthesis and replication, leading to bacterial death.

This ingredient has been used in drugs with the following functions (note: it does not mean that the ingredient itself has the following health functions)

Related Drugs

Ciprofloxacin Lactate Eye Drops
Ingredients	Ciprofloxacin lactate
Indication	Long-term and large-scale use, after local absorption, may produce the same drug interactions as systemic medication, as follows: 1. Urine alkalinizing agents can reduce the solubility of this product in urine, leading to crystalluria and nephrotoxicity. 2. When this product is used in combination with theophylline, competitive inhibition with the cytochrome P450 binding site may lead to a significant reduction in the liver clearance of theophylline, prolonged blood elimination half-life (t1/2b), increased blood drug concentration, and theophylline poisoning symptoms such as nausea, vomiting, tremor, restlessness, excitement, convulsions, palpitations, etc. Therefore, theophylline blood drug concentration should be measured and the dose adjusted when used in combination. 3. Cyclosporine and this product can increase the blood drug concentration of the former. The blood concentration of cyclosporine must be monitored and the dose adjusted. 4. When this product is used in combination with the anticoagulant warfarin, it can enhance the anticoagulant effect of the latter. When used in combination, the patient's prothrombin time should be closely monitored. 5. Probenecid can reduce the secretion of this product from the renal tubules by about 50%. When used together, it may cause toxicity due to the increase in the blood concentration of this product. 6. This product interferes with the metabolism of caffeine, resulting in reduced caffeine clearance, prolonged blood elimination half-life (t1/2b), and may cause central nervous system toxicity.
Specifications	5ml: 15mg (based on ciprofloxacin); 8ml: 24mg (based on ciprofloxacin)

Ciprofloxacin lactate

Ciprofloxacin Lactate Sodium Chloride Injection
Ingredients	The main ingredients of this product are: Ciprofloxacin lactate Chemical name: 1-cyclopropyl-6-fluoro-1,4-dihydro-4-oxo-7 (1-piperazinyl)-3-quinolinecarboxylic acid lactate Molecular formula: C17H18FN3O3C3H6O3 Molecular weight: 421.43
Indication	1 Urine alkalinizing agents can reduce the solubility of this product in urine, leading to crystalluria and nephrotoxicity. 2 When this product is used in combination with theophylline, competitive inhibition of the cytochrome P450 binding site may lead to a significant reduction in the liver clearance of theophylline, a prolonged blood elimination half-life, an increase in blood drug concentration, and the appearance of symptoms of theophylline poisoning, such as nausea, vomiting, tremor, restlessness, excitement, convulsions, palpitations, etc. Therefore, theophylline blood drug concentration should be measured and the dose adjusted when used in combination. 3 Cyclosporine combined with this product can increase the blood drug concentration of the former. The blood concentration of cyclosporine must be monitored and the dose adjusted. 4 When this product is used in combination with the anticoagulant warfarin, it can enhance the anticoagulant effect of the latter. When used in combination, the patient's prothrombin time should be closely monitored. 5 Probenecid can reduce the secretion of this product from the renal tubules by about 50%. When used in combination, toxicity may occur due to the increased blood concentration of this product. 6. This product interferes with the metabolism of caffeine, resulting in reduced caffeine clearance, prolonged blood elimination half-life, and possible central nervous system toxicity.
Specifications	Calculated according to ciprofloxacin: 100ml: 0.2g

See More Related Drugs

Registered Holders

Shaoxing Jingxin Pharmaceutical Co., Ltd.

China
Active
Yueyang Tonglian Pharmaceutical Co., Ltd.

China
Active
Zhejiang Guobang Pharmaceutical Co., Ltd.

China
Active

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