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Salinomycin

Salinomycin structure

CAS No:
53003-10-4
Formula:
C42H70O11
Chemical Name:
Salinomycin
Synonyms:
coxistac;SALINOMYCIN GRANULE;Salinomycin Premix 12%;SALINOMYCIN FROM STREPTOMYCES ALBUS;SALINOMYCIN 90%;SV sodium salt,2,5 salinomycin hydrate;(2R)-2-((5S)-6-{5-[(10S,12R)-2-((6S,5R)-5-Ethyl-5-hydroxy-6-methylperhydro-2H-pyran-2-yl)-15-hydroxy-2,10,12-trimethyl-1,6,8-trioxadispiro[4.1.5.3]pentadec-13-en-9-yl](1S,2S,3S,5R)-2-hydroxy-1,3-dimethyl-4-oxoheptyl}-5-methylperhydro-2H-pyran-2-yl)butanoic acid;Salinomycin
Categories:
Active Pharmaceutical Ingredients > Antiparasitic Drugs

Description

Salinomycin is an anticoccidial drug with potent anti-bacterial activity and an novel anticancer agent targeting human cancer stem cells.

Salinomycin was found in the culture mycelium of Streptomyces albus by Otake et al. of the University of Tokyo in 1973. Like other polyether ionophore antibiotics, it shows activity against gram-positive bacteria, fungi, and Coccidium. Salinomycin has been used as a feed additive to protect poultry against coccidial infections.

solid

ChEBI: Salinomycin is a polyketide and a spiroketal. It has a role as an animal growth promotant and a potassium ionophore.

Chemical structure: polyether

Salinomycin Basic Attributes

Molecular Weight：

751

Exact Mass：

751.00

EC Number：

258-290-1

Color/Form：

White to light yellow

HScode：

2309901000

Characteristics

PSA：

161 Å²

XLogP3：

log Kow = 8.53 (est)

Appearance：

White powder

Density：

1.18±0.1 g/cm3(Predicted)

Melting Point：

112.5-113.5 °C(lit.)

Boiling Point：

839.2±65.0 °C(Predicted)

Flash Point：

>110°(230°F)

Refractive Index：

1.547

Water Solubility：

Soluble in methanol. Insoluble in water

Storage Conditions：

2-8°C

Vapor Pressure：

6.37X10-23 mm Hg at 25 °C (est)

Toxicity：

LD50 in mice (mg/kg): 18 i.p.; 50 orally (Miyazaki)

Specific rotation：

D25 -63° (c = 1 in ethanol)

PKA：

6.4 (DMF)

Critical Temperature & Pressure：

Sealed in dry,2-8°C

Safety Information

Packing level：

Hazard category：

6.1(a)

Transport codes：

UN 3462 6.1/PG 2

wgk germany：

hazard class code：

T,Xi

safety instructions：

45-36-26

RTECS Number：

VO8620000

Marks：

T,Xi

Stability/Shelf Life：

Stable, but may be heat sensitive - keep cool. Incompatible with strong oxidizing agents.

Precautionary statement(s)：

P264-P301 + P310

Hazard Statements：

25-36/37/38

RIDADR：

UN 3462 6.1/PG 2

Salinomycin Use and Manufacturing

Salinomycin is a polyether ionophore with broad spectrum Gram positive and anti-coccidial activity. Salinomycin has a high affinity for monovalent cations, particularly potassium. Salinomycin is used to control coccidia in animals and for growth promotion in ruminants. Recently, salinomycin has been shown to inhibit cancer stem cells and is >100 times more potent than taxol. While the mechanism of action is unknown, it was noted that among the 60,000 compounds screened, another monovalent ionophore, nigericin, and a chloride channel inhibitor, avermectin, were also active.

antibacterial

Salinomycin was used as a standard in the development of LC-MS/MS method for detection of residual coccidiostats in egg and muscle samples. It was used to screen out CD44+CD24-mesenchymal-like subpopulation within breast carcinomas.

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