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Amikacin Disulfate

Amikacin Disulfate structure

CAS No:
39831-55-5
Formula:
C22H45N5O17S
Chemical Name:
Amikacin Disulfate
Synonyms:
AMIKACIN DISULFATE;AMIKACIN DISULFATE SALT;(s)-ysulfate(1:2)(salt);antibioticbb-k8sulfate;α-d-glucopyranosyl-(1-4))-n(sup 1)-(4-amino-2-hydroxy-1-oxobutyl)-2-deoxy;Amikacin disulphate salt;1-N-[L-(-)-γ-AMino-α-hydroxybutyryl]kanaMycin A Sulfate;AMika
Categories:
Biochemical Engineering > Saccharides

Description

Amikacin sulfate(BAY416651 sulfate) is a semi-synthetic aminoglycoside antibiotic derived from kanamycin A.Target: AntibacterialAmikacin disrupts bacterial protein synthesis by binding to the 30S ribosome of susceptible organisms. Binding interferes with mRNA binding and tRNA acceptor sites leading to the production of non-functional or toxic peptides. Other mechanisms not fully understood may confer the bactericidal effects of amikacin. Amikacin is also nephrotoxic and ototoxic. Amikaci

White Solid

ChEBI: An aminoglycoside sulfate salt obtained by combining amikacin with two molar equivalents of sulfuric acid.

Poison by intravenous route.Moderately toxic by intraperitoneal and subcutaneousroutes. An experimental teratogen. Other experimentalreproductive effects. When heated to decomposition itemits very toxic fumes of NOx and SOx.

Amikacin Disulfate Basic Attributes

Molecular Weight：

683.68

Exact Mass：

781.220520

BRN：

6172633

EC Number：

254-648-6

Color/Form：

white to off-white

HScode：

29419000

Characteristics

PSA：

497.90000

XLogP3：

-4.37610

Appearance：

white to off-white

Melting Point：

220-230 C

Boiling Point：

981.8ºC at 760 mmHg

Water Solubility：

Soluble in water at 50mg/ml with warming

Storage Conditions：

2-8°C

Toxicity：

LD50 oral in rabbit: > 3gm/kg

Flammability characteristics：

Flammable; burning produces toxic nitrogen oxides and sulfur oxide fumes

Specific rotation：

D22 +74.75° (water)

PH：

pH(10g/L, 25℃) : 2.0～4.0

Critical Temperature & Pressure：

Inert atmosphere,2-8°C

Safety Information

Transport codes：

NONH for all modes of transport

wgk germany：

hazard class code：

safety instructions：

26-36

RTECS Number：

WK1961200

Marks：

Storage features：

Warehouse ventilated, low temperature and dry

Hazard Statements：

36/37/38

Toxicity

Toxicity class：

moderately toxic

Amikacin Disulfate Use and Manufacturing

Semisynthetic aminoglycoside antibiotic derived from Kanamycin A. Antibacterial.

Analgesic

Amikacin disulfate is used as an aminoglycoside antibiotic derived from Kanamycin A, used for treating infections with multidrug resistant Gram negative bacteria such as Pseudomonas aeruginosa, Acinetobacter, and Enterobacter. It is commonly used in the treatment of drug-resistant mycobacteria. It is used to study organism-directed delivery of antibiotics as well as drug resistance.

Material

Acetone

Sulfuric acid

Drug Function and Efficacy

Amikacin sulfate is an aminoglycoside antibiotic that has a good effect on most Enterobacteriaceae and is stable to the aminoglycoside inactivating enzymes produced by many intestinal Gram-negative bacilli. Its mechanism of action is to act on the 30S subunit of bacterial ribosomes and inhibit bacterial protein synthesis. Combination with semi-synthetic penicillins or cephalosporins often produces a synergistic antibacterial effect.

This ingredient has been used in drugs with the following functions (note: it does not mean that the ingredient itself has the following health functions)

Related Drugs

Amikacin Sulfate Injection
Ingredients	This product is a sterile aqueous solution of amikacin sulfate. The content of amikacin (C22H43N5O13) should be 90.0-110.0% of the labeled amount.
Indication	1. When used in combination with other aminoglycosides or applied topically or systemically one after the other, it may increase ototoxicity, nephrotoxicity and neuromuscular blocking effects. 2. When used in combination with neuromuscular blockers, it may aggravate neuromuscular blocking effects, leading to muscle weakness, respiratory depression, etc. 3. When used in combination with capreomycin, cisplatin, ethacrynic acid, furosemide or vancomycin (or norvancomycin), or applied topically or systemically one after the other, it may increase ototoxicity and nephrotoxicity. 4. When used topically or systemically with cephalothin or cefazolin, it may increase nephrotoxicity. 5. When used in combination with polymyxin injections, or applied topically or systemically one after the other, it may increase nephrotoxicity and neuromuscular blocking effects. 6. Other nephrotoxic and ototoxic drugs should not be used in combination with this product or applied one after the other, so as not to aggravate nephrotoxicity or ototoxicity. 7. When aminoglycosides and beta-lactams (cephalosporins and penicillins) are mixed, they may lead to mutual inactivation. When this product is used in combination with the above-mentioned antibiotics, it must be dripped in separate bottles. It is also not suitable to be infused in the same bottle with other drugs.
Specifications	According to C22H43N5O13, 2ml: 0.2g (200,000 units)
Manufacturer	Dali Pharmaceutical Co., Ltd.

Registered Holders

ACS DOBFAR S. P. A.

Brazil
Active
ACS DOBFAR SPA

Italy
Active
Shandong Anxin Pharmaceutical Co.,Ltd.

Japan
Active

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Guide of Amikacin Disulfate

Description
Basic Attributes
Characteristics
Safety Information
Toxicity
Use and Manufacturing
Material
Drug Function and Efficacy
Related Drugs
Registered Holders
Recommended Suppliers
Learn More Other Chemicals

Amikacin Disulfate

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