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LX-4211

LX-4211 structure

CAS No:
1018899-04-1
Formula:
C21H25ClO5S
Chemical Name:
LX-4211
Synonyms:
(2S,3R,4R,5S,6R)-2-[4-chloro-3-(4-ethoxybenzyl)phenyl]-6-(methylsulfanyl)tetrahydro-2-H-pyran-3,4,5-triol;CS-1853;LX4211; LX 4211; LX4211; LX 4211;LX-4211;(2S,3R,4R,5S,6R)-2-(4-chloro-3-(4-ethoxybenzyl)phenyl)-6-(Methylthio)tetrahydro-2H-pyran-3,4,5-triol;(5S)-Methyl 5-C-[4-chloro-3-[(4-ethoxyphenyl)Methyl]phenyl]-1-thio-beta-L-xylopyranoside;LX4211/LX-4211;LP 802034
Categories:
Biochemical Engineering > Saccharides

Description

Sotagliflozin has been used in trials studying the treatment of Renal impairment, Hepatic Impairment, Type 1 Diabetes Mellitus, and High Level of Sugar (Glucose) in the Blood.|Sotagliflozin is an orally bioavailable inhibitor of the sodium-glucose co-transporter subtype 1 (SGLT1) and 2 (SGLT2), with potential antihyperglycemic activity. Upon oral administration, sotagliflozin binds to and blocks both SGLT1 in the gastrointestinal (GI) tract and SGLT2 in the kidneys, thereby suppressing the absorption of glucose from the GI tract and the reabsorption of glucose by the proximal tubule into the bloodstream, respectively. This decreases glucose uptake and enhances the urinary excretion of glucose, which lowers and/or normalizes blood glucose levels. SGLT1 is the primary transporter responsible for glucose absorption from the GI tract. SGLT2, a transport protein exclusively expressed in the proximal renal tubules, mediates approximately 90% of renal glucose reabsorption from tubular fluid.

LX-4211 Basic Attributes

Molecular Weight：

424.94

Exact Mass：

424.94

UNII：

6B4ZBS263Y

DSSTox ID：

DTXSID20144314

NCI Thesaurus Code：

C119623

Color/Form：

White to off-white

ATC Code：

A10|A - Alimentary tract and metabolism

Characteristics

Density：

1.37±0.1 g/cm3(Predicted)

Boiling Point：

607.9±55.0 °C(Predicted)

PKA：

12.87±0.70(Predicted)

Critical Temperature & Pressure：

Store at -20°C

Safety Information

GHS Classification：

|Warning|H351 (50%): Suspected of causing cancer [Warning Carcinogenicity]|P201, P202, P260, P273, P281, P308+P313, P314, P405, and P501|Aggregated GHS information provided by 3 companies from 3 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.

Drug Information

Drug Indication：

Zynquista is indicated as an adjunct to insulin therapy to improve glycaemic control in adults with type 1 diabetes mellitus with a Body Mass Index (BMI) ≥ 27 kg/m2, who have failed to achieve adequate glycaemic control despite optimal insulin therapy.|Treatment of type I diabetes mellitus|Treatment of type II diabetes mellitus

MeSH：

Compounds that inhibit SODIUM-GLUCOSE TRANSPORTER 2. They lower blood sugar by preventing the reabsorption of glucose by the kidney, and are used in the treatment of TYPE 2 DIABETES MELLITUS. (See all compounds classified as Sodium-Glucose Transporter 2 Inhibitors.)

MeSH Entry Terms：

(2S,3R,4R,5S,6R)-2-(4-chloro-3-(4-ethoxybenzyl)phenyl)-6-(methylthio)tetrahydro-2H-pyran-3,4,5-triol

LX-4211 Use and Manufacturing

Uses

Sotagliflozin is used for the treatment of patients with type 1 diabetes mellitus.

Use Classification：

Human drugs -> Zynquista -> EMA Drug Category|Drugs used in diabetes -> Human pharmacotherapeutic group|Human Drugs -> EU pediatric investigation plans

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high purity hot sale Sotagliflozin 99% high quality see COA KANBEI

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Guide of LX-4211

Description
Basic Attributes
Characteristics
Safety Information
Drug Information
Use and Manufacturing
Recommended Suppliers
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LX-4211

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