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Lincomycin hydrochloride

Lincomycin hydrochloride structure

CAS No:
859-18-7
Formula:
C18H35ClN2O6S
Chemical Name:
Lincomycin hydrochloride
Synonyms:
METHYL 6,8-DIDEOXY-6-(1-METHYL-4-PROPYL-2-PYRROLIDINECARBOXAMIDO)-1-THIO-D-ERYTHRO-ALPHA-D-GALACTOOCTOPYRANOSIDE HYDROCHLORIDE;LINCOMYCIN HYDROCHLORIDE;LINCOCIN HYDROCHLORIDE;lincomycin standard solution;ALPHA-METHYL-6,8-DIDEOXY-6-[1-METHYL-4-PROPYL-2-PYRROLIDINECARBOXAMIDO]-1-THIO-D-ERYTHRO-D-GALACTOOCTOPYRANOSIDE HYDROCHLORIDE;U-10149A;N-[2-HYDROXY-1-(3,4,5-TRIHYDROXY-6-METHYLSULFANYL-OXAN-2-YL)-PROPYL]-1-METHYL-4-PROPYL-PYRROLIDINE-2-CARBOXAMIDE;D-erythro-.alpha.-D-galacto-Octopyranoside, methyl 6,8-dideoxy-6-(2S,4R)-1-methyl-4-propyl-2-pyrrolidinylcarbonylamino-1-thio-, monohydrochloride
Categories:
Pharmaceutical Intermediates > Bulk Drug Intermediates

Description

An antibiotic produced by Streptomyces lincolnensis var. lincolnensis. It has been used in the treatment of staphylococcal, streptococcal, and Bacteroides fragilis infections.

Crystalline

Chemical structure: macrolide

Lincomycin hydrochloride Basic Attributes

Molecular Weight：

443

Exact Mass：

442.1904357

BRN：

4171650

EC Number：

212-726-7

NSC Number：

70731

DSSTox ID：

DTXSID7047803

Color/Form：

white to white with yellow cast

HScode：

29419000

Characteristics

Melting Point：

156-158C

Water Solubility：

Soluble in water.

Critical Temperature & Pressure：

2-8°C

Safety Information

wgk germany：

hazard class code：

Xi,Xn

safety instructions：

26-36

RTECS Number：

RH6315000

Hazard Statements：

36/37/38-20/21/22

GHS Classification：

|Warning|H315 (60.26%): Causes skin irritation [Warning Skin corrosion/irritation]|P261, P264, P271, P272, P273, P280, P302+P352, P304+P340, P305+P351+P338, P312, P321, P332+P313, P333+P313, P337+P313, P362, P363, P391, P403+P233, P405, and P501|Aggregated GHS information provided by 78 companies from 10 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.

Drug Information

MeSH：

Substances that inhibit the growth or reproduction of BACTERIA. (See all compounds classified as Anti-Bacterial Agents.)|Compounds which inhibit the synthesis of proteins. They are usually ANTI-BACTERIAL AGENTS or toxins. Mechanism of the action of inhibition includes the interruption of peptide-chain elongation, the blocking the A site of ribosomes, the misreading of the genetic code or the prevention of the attachment of oligosaccharide side chains to glycoproteins. (See all compounds classified as Protein Synthesis Inhibitors.)

MeSH Entry Terms：

Epilincomycin

Lincomycin hydrochloride Use and Manufacturing

Uses

An antibiotic produced by Streptomyces lincolnensis. Lincomycin is a lincosamide antibiotic that forms cross-links within the peptidyl transferase loop region of the 23S rRNA. Inhibits bacterial protein synthesis. Antibacterial.

Antibacterial;Ribosomal protein synthesis inhibitor

Lincomycin hydrochloride is a salt of lincomycin formed at the basic N-methylproline. The hydrochloride salt is the preferred formulation for pharmaceutical use. Lincomycin hydrochloride is a broad spectrum antibiotic with activity against anaerobic bacteria and protozoans. Lincomycin acts by binding to the 23S ribosomal subunit, blocking protein synthesis. Lincomycin has been extensively studied with over 7,000 literature citations.

Use Classification：

Human Drugs -> FDA Approved Drug Products with Therapeutic Equivalence Evaluations (Orange Book) -> Active Ingredients|Animal Drugs -> FDA Approved Animal Drug Products (Green Book) -> Active Ingredients

Drug Function and Efficacy

It has high antibacterial activity against common aerobic Gram-positive bacteria, such as Staphylococcus aureus (including those resistant to penicillin G), Staphylococcus epidermidis, β-hemolytic Streptococcus, viridans Streptococcus and Streptococcus pneumoniae. It has good antibacterial effect on anaerobic bacteria, including Clostridium diphtheriae, and Clostridium perfringens. It has no activity against Gram-negative bacteria such as Enterococcus, meningococci, Neisseria gonorrhoeae, and Haemophilus influenzae, as well as fungi. There is no cross-resistance with penicillin, chloramphenicol, cephalosporins and tetracyclines, and there is partial cross-resistance with macrolides. It acts on the 50S subunit of the ribosome of sensitive bacteria, preventing the extension of the peptide chain, thereby inhibiting the protein synthesis of bacterial cells. It is generally an antibacterial agent, but at high concentrations, it also has a bactericidal effect on certain bacteria.

This ingredient has been used in drugs with the following functions (note: it does not mean that the ingredient itself has the following health functions)

Related Drugs

Lincomycin Hydrochloride Injection
Ingredients	The main ingredient is lincomycin hydrochloride, and its chemical name is 6-(1-methyl-trans-4-propyl-L-2-pyrrolidinecarboxamido)-1-thio-6,8-dideoxy-D-erythro-alpha;-D-galacto-octinopyranoside hydrochloride hydrate. Its structural formula is: Molecular formula: C18H34N2O6SHClH2O Molecular weight: 461.02
Indication	1. It can enhance the neuromuscular blockade of inhaled anesthetics, leading to skeletal muscle weakness and respiratory depression or paralysis (apnea). Caution should be taken when used in combination during or after surgery. Treatment with anticholinesterase drugs or calcium salts is expected to be effective. 2. When used in combination with antiperistaltic antidiarrheal drugs and antidiarrheal drugs containing white clay, this product may cause pseudomembranous colitis with severe watery diarrhea during the course of treatment or even a few weeks after the course of treatment. Because it can delay the excretion of colonic endotoxins, thereby causing prolonged and aggravated diarrhea, antiperistaltic antidiarrheal drugs should not be used in combination. When this product is used in combination with antidiarrheal drugs containing white clay, the absorption of the former will be significantly reduced, so the two should not be taken at the same time, and a certain interval (at least 2 hours) is required. 3. This product has a neuromuscular blocking effect. When used in combination with anti-myasthenic drugs, the latter will weaken the effect on skeletal muscles. In order to control the symptoms of myasthenia gravis, the dose of anti-myasthenic drugs should be adjusted when used in combination. 4. Chloramphenicol or erythromycin can replace this product at the target site, or inhibit the latter from binding to the bacterial ribosome 50S subunit. In vitro tests show that lincomycin and erythromycin have antagonistic effects, so lincomycin should not be used in combination with chloramphenicol or erythromycin. 5. When used in combination with opioid analgesics, the respiratory depressant effect of this product and the central respiratory depressant effect of opioids may lead to prolonged respiratory depression or respiratory paralysis (apnea) due to cumulative phenomena, so patients must be closely observed or monitored. 6. This product can enhance the effect of neuromuscular blocking drugs, and the two should be avoided in combination. 7. It is incompatible with neomycin and kanamycin when intravenously dripped in the same bottle.
Specifications	1ml:0.2g (calculated as G8H34N206S)

Lincomycin Hydrochloride Tablets
Ingredients	The main ingredient of this product is lincomycin hydrochloride.
Indication	1. It can enhance the neuromuscular blockade of inhaled anesthetics, leading to skeletal muscle weakness and respiratory depression or paralysis (apnea). Caution should be taken when used in combination during or after surgery. Treatment with anticholinesterase drugs or calcium salts is expected to be effective. 2. When used in combination with antiperistaltic antidiarrheal drugs and antidiarrheal drugs containing white clay, this product may cause pseudomembranous colitis with severe watery diarrhea during the course of treatment or even a few weeks after the course of treatment. Because it can delay the excretion of colonic endotoxins, thereby causing prolonged and aggravated diarrhea, antiperistaltic antidiarrheal drugs should not be used in combination. When this product is used in combination with antidiarrheal drugs containing white clay, the absorption of the former will be significantly reduced, so the two should not be taken at the same time, and a certain interval (at least 2 hours) is required. 3. This product has a neuromuscular blocking effect. When used in combination with anti-myasthenic drugs, the latter will weaken the effect on skeletal muscles. In order to control the symptoms of myasthenia gravis, the dose of anti-myasthenic drugs should be adjusted when used in combination. 4. Chloramphenicol or erythromycin can replace this product at the target site, or inhibit the latter from binding to the bacterial ribosome 50S subunit. In vitro tests show that this product has an antagonistic effect with erythromycin, so this product should not be used in combination with chloramphenicol or erythromycin. 5. When used in combination with opioid analgesics, the respiratory depression of this product and the central respiratory depression of opioids may lead to prolonged respiratory depression or respiratory paralysis (apnea) due to the cumulative phenomenon, so the patient must be closely observed or monitored. 6. This product can enhance the effect of neuromuscular blocking drugs, and the two should be avoided in combination.
Specifications	0.5g (calculated as C18H34N2O6S)
Manufacturer	Jiangxi Nanchang Sanghai Pharmaceutical Co., Ltd.

Lincomycin Hydrochloride Injection
Ingredients	The main ingredient of this product is lincomycin hydrochloride.
Indication	1. It can enhance the neuromuscular blockade of inhaled anesthetics, leading to skeletal muscle weakness and respiratory depression or paralysis (apnea). Caution should be taken when used in combination during or after surgery. Treatment with anticholinesterase drugs or calcium salts is expected to be effective. 2. When used in combination with antiperistaltic antidiarrheal drugs and antidiarrheal drugs containing white clay, this product may cause pseudomembranous colitis with severe watery diarrhea during the course of treatment or even a few weeks after the course of treatment. Because it can delay the excretion of colonic endotoxins, thereby causing prolonged and aggravated diarrhea, antiperistaltic antidiarrheal drugs should not be used in combination. When this product is used in combination with antidiarrheal drugs containing white clay, the absorption of the former will be significantly reduced, so the two should not be taken at the same time, and a certain interval (at least 2 hours) is required. 3. This product has a neuromuscular blocking effect. When used in combination with anti-myasthenic drugs, the latter will weaken the effect on skeletal muscles. In order to control the symptoms of myasthenia gravis, the dose of anti-myasthenic drugs should be adjusted when used in combination. 4. Chloramphenicol or erythromycin can replace this product at the target site, or inhibit the latter from binding to the bacterial ribosome 50S subunit. In vitro tests show that lincomycin and erythromycin have antagonistic effects, so lincomycin should not be used in combination with chloramphenicol or erythromycin. 5. When used in combination with opioid analgesics, the respiratory depressant effect of this product and the central respiratory depressant effect of opioids may lead to prolonged respiratory depression or respiratory paralysis (apnea) due to cumulative phenomena, so patients must be closely observed or monitored. 6. This product can enhance the effect of neuromuscular blocking drugs, and the two should be avoided in combination. 7. It is incompatible with neomycin and kanamycin when intravenously dripped in the same bottle.
Specifications	Calculated according to C18H34N2O6S 2ml:0.6g
Manufacturer	Shanghai Harvest Pharmaceutical Co., Ltd.

See More Related Drugs

Registered Holders

XINYU PHARMACEUTICAL CO LTD

United States
Active
Taishan City Chemical Pharmaceutical Co., Ltd.

China
Active
Shanghai SPH New ASIA Pharmaceutical Co., Ltd.

China
Active

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