S(-)-RACLOPRIDE L-TARTRATE
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S(-)-RACLOPRIDE L-TARTRATE
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CAS No:
84225-95-6
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Formula:
C15H20Cl2N2O3
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Chemical Name:
S(-)-RACLOPRIDE L-TARTRATE
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Synonyms:
(S)-3,5-dichloro-N-((1-ethylpyrrolidin -2-yl)methyl)-2-hydroxy-6- methoxybenzamide (2R,3R) -2,3-dihydroxysuccinate;(2S)-3,5-DICHLORO-N-[(1-ETHYL-2-PYRROLIDINYL)-METHYL]-6- METHOXYSALICYLAMIDE;BENZAMIDE, 3,5-DICHLORO-N-[[(2S)-1-ETHYL-2-PYRROLIDINYL]METHYL]-2-HYDROXY-6-METHOXY-;3,5-Dichloro-N-[(2S)-1-ethyl-2-pyrrolidinyl]-2-hydroxy-6-methoxybenzamide;FLA-870;RAC;3,5-Dichloro-N-[[(2S)-1-ethyl-2-pyrrolidinyl]methyl]-2-methoxy-6-hydroxybenzamide;3,5-Dichloro-N-[[(2S)-1-ethylpyrrolidine-2α-yl]methyl]2-hydroxy-6-methoxybenzamide
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CAS No:
Description
3,5-dichloro-N-[[(2S)-1-ethyl-2-pyrrolidinyl]methyl]-2-hydroxy-6-methoxybenzamide is a member of salicylamides.|Raclopride has been used in trials studying Parkinson Disease.|A substituted benzamide that has antipsychotic properties. It is a dopamine D2 receptor (see RECEPTORS, DOPAMINE D2) antagonist.
Raclopride is a selective dopamine D2/D3receptor antagonist with Kivalues of 1.8, 3.5, 2,400, and 18,000 nM for D2, D3, D4, and D1receptors, respectively. It passes the blood brain barrier and can be used inin vivobinding and autoradiography studies of the dopamine system under normal and pathological conditions such as Huntington’s disease.
Yellowish solid
ChEBI: 3,5-dichloro-N-[[(2S)-1-ethyl-2-pyrrolidinyl]methyl]-2-hydroxy-6-methoxybenzamide is a member of salicylamides.
S(-)-RACLOPRIDE L-TARTRATE Basic Attributes
347.24
347.24
430K3SOZ7G
DTXSID9045687
white
2933.99.8290
Characteristics
61.8 Ų
1.288±0.06 g/cm3(Predicted)
52.0 to 56.0 °C
420.3±45.0 °C(Predicted)
5.93±0.50(Predicted)
Keep in dark place,Sealed in dry,2-8°C
Drug Information
Drugs that bind to but do not activate DOPAMINE RECEPTORS, thereby blocking the actions of dopamine or exogenous agonists. Many drugs used in the treatment of psychotic disorders (ANTIPSYCHOTIC AGENTS) are dopamine antagonists, although their therapeutic effects may be due to long-term adjustments of the brain rather than to the acute effects of blocking dopamine receptors. Dopamine antagonists have been used for several other clinical purposes including as ANTIEMETICS, in the treatment of Tourette syndrome, and for hiccup. Dopamine receptor blockade is associated with NEUROLEPTIC MALIGNANT SYNDROME. (See all compounds classified as Dopamine Antagonists.)|Agents that control agitated psychotic behavior, alleviate acute psychotic states, reduce psychotic symptoms, and exert a quieting effect. They are used in SCHIZOPHRENIA; senile dementia; transient psychosis following surgery; or MYOCARDIAL INFARCTION; etc. These drugs are often referred to as neuroleptics alluding to the tendency to produce neurological side effects, but not all antipsychotics are likely to produce such effects. Many of these drugs may also be effective against nausea, emesis, and pruritus. (See all compounds classified as Antipsychotic Agents.)
C11, Raclopride
S(-)-RACLOPRIDE L-TARTRATE Use and Manufacturing
neuroleptic;selective dopamine D1/D2 receptors antagonist
A labelled dopamine receptor
Raclopride is a potent D2DR/D3DR antagonist.
Computed Properties
Molecular Weight:347.2
XLogP3:2.9
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:5
Exact Mass:346.0850979
Monoisotopic Mass:346.0850979
Topological Polar Surface Area:61.8
Heavy Atom Count:22
Complexity:386
Defined Atom Stereocenter Count:1
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes
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