(R)-Tolterodine L-tartrate
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(R)-Tolterodine L-tartrate
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CAS No:
209747-05-7
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Formula:
C22H31NO.xC4H6O6
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Chemical Name:
(R)-Tolterodine L-tartrate
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Synonyms:
Phenol,2-[(1R)-3-[bis(1-methylethyl)amino]-1-phenylpropyl]-4-methyl-,(2R,3R)-2,3-dihydroxybutanedioate (1:?);Phenol,2-[(1R)-3-[bis(1-methylethyl)amino]-1-phenylpropyl]-4-methyl-,[R-(R*,R*)]-2,3-dihydroxybutanedioate (salt);Phenol,2-[(1R)-3-[bis(1-methylethyl)amino]-1-phenylpropyl]-4-methyl-,(2R,3R)-2,3-dihydroxybutanedioate (salt);(R)-Tolterodine L-tartrate
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CAS No:
Description
Tolterodine Tartrate is the tartrate salt form of tolterodine, a benzhydryl compound and a muscarinic receptor antagonist possessing both antimuscarinic and antispasmodic properties. Both tolterodine and its active metabolite, 5-hydroxymethyltolterodine, competitively blocks muscarinic receptors, thereby inhibiting acetylcholine receptor binding. This antagonistic action results in an increase in residual urine, reflecting an incomplete emptying of the bladder, and a decrease in detrusor pressure, indicating an antimuscarinic action on the lower urinary tract.. The 5-hydroxymethyl metabolite appears to contribute significantly to the therapeutic effects.|An ANTIMUSCARINIC AGENT selective for the MUSCARINIC RECEPTORS of the BLADDER that is used in the treatment of URINARY INCONTINENCE and URINARY URGE INCONTINENCE.
Safety Information
|Danger|H301 (67.86%): Toxic if swallowed [Danger Acute toxicity, oral]|P201, P202, P264, P270, P273, P281, P301+P310, P301+P312, P308+P313, P321, P330, P391, P405, and P501|Aggregated GHS information provided by 112 companies from 12 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.
Drug Information
Drugs used in the treatment of urogenital conditions and diseases such as URINARY INCONTINENCE; PROSTATIC HYPERPLASIA; and ERECTILE DYSFUNCTION. (See all compounds classified as Urological Agents.)|Drugs that bind to but do not activate MUSCARINIC RECEPTORS, thereby blocking the actions of endogenous ACETYLCHOLINE or exogenous agonists. Muscarinic antagonists have widespread effects including actions on the iris and ciliary muscle of the eye, the heart and blood vessels, secretions of the respiratory tract, GI system, and salivary glands, GI motility, urinary bladder tone, and the central nervous system. (See all compounds classified as Muscarinic Antagonists.)
Detrol
(R)-Tolterodine L-tartrate Use and Manufacturing
Human Drugs -> FDA Approved Drug Products with Therapeutic Equivalence Evaluations (Orange Book) -> Active Ingredients
Computed Properties
Molecular Weight:475.6
Hydrogen Bond Donor Count:5
Hydrogen Bond Acceptor Count:8
Rotatable Bond Count:10
Exact Mass:475.25700252
Monoisotopic Mass:475.25700252
Topological Polar Surface Area:139
Heavy Atom Count:34
Complexity:474
Defined Atom Stereocenter Count:3
Covalently-Bonded Unit Count:2
Compound Is Canonicalized:Yes
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