KAZUSAMYCIN A FROM STREPTOMYCES SP.
-
KAZUSAMYCIN A FROM STREPTOMYCES SP.
structure -
-
CAS No:
92090-94-3
-
Formula:
C33H48O7
-
Chemical Name:
KAZUSAMYCIN A FROM STREPTOMYCES SP.
-
Synonyms:
KAZUSAMYCIN A FROM STREPTOMYCES SP.;antibiotic81-484;antibioticcl1957b;kazusamycin;kazusamycina;19-(3,6-Dihydro-3-methyl-6-oxo-2H-pyran-2-yl)-17-ethyl-6-hydroxy-9-(hydroxymethyl)-3,5,7,11,15-pentamethyl-8-oxo-2,10,12,16,18-nonadecapentenoic acid;PD-114721;2,10,12,16,18-Nonadecapentaenoic acid, 19-(3,6-dihydro-3-methyl-6-oxo-2H-pyran-2-yl)-17-ethyl-6-hydroxy-9-(hydroxymethyl)-3,5,7,11,15-pentamethyl-8-oxo-, (2E,10E,12E,16Z,18E)-
-
CAS No:
Characteristics
121.13000
5.75710
1.109±0.06 g/cm3(Predicted)
761.5±60.0 °C(Predicted)
5.10±0.33(Predicted)
−20°C
Drug Information
Chemical substances, produced by microorganisms, inhibiting or preventing the proliferation of neoplasms. (See all compounds classified as Antibiotics, Antineoplastic.)
16-hydroxyleptomycin B
KAZUSAMYCIN A FROM STREPTOMYCES SP. Use and Manufacturing
Kazusamycin A is a minor member of the leptomycin complex isolated from some Streptomyces species. It is an hydroxylated analogue of leptomycin B, a nuclear export inhibitor. Kazusamycin A exhibits potent antitumour activity both in vitro and in vivo against P388 and L1210 cell lines, and also shows strong antibacterial and antifungal activity.
Kazusamycin A is a potent antibiotic shown to induce G2 cell cycle arrest and delay M phase.
Computed Properties
Molecular Weight:556.7
XLogP3:6.6
Hydrogen Bond Donor Count:3
Hydrogen Bond Acceptor Count:7
Rotatable Bond Count:16
Exact Mass:556.34000387
Monoisotopic Mass:556.34000387
Topological Polar Surface Area:121
Heavy Atom Count:40
Complexity:1040
Undefined Atom Stereocenter Count:7
Undefined Bond Stereocenter Count:5
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes
Learn More Other Chemicals
-
AUSTOCYSTIN A FROM ASPERGILLUS USTUS
55256-58-1
-
Guanidylfungin ACAS:94116-22-0 Remarks:It is produced by the strain of Streptomyces hygroscopicus 662. It is a macrolide antibiotic. It has weak anti-gram-negative bacterial and fungal activity.
94116-22-0
-
AMINOPEPTIDASE FROM AEROMONASPROTEOLYTIC A
37288-67-8
-
A mixture of compounds from (dodecakis(p-tolylthio)phthalocyaninato)copper(II) to(hexadecakis(p-tolylthio)phthalocyaninato)copper(II) Formula
101408-30-4
-
Demethylolivomycin ACAS:86917-61-5 Remarks:Demethylolivomycin A is an antitumor antibiotic produced by Streptomyces aburaviensis. It has anti-Gram-positive bacteria and anti-leukemia P388 activity. Formula
86917-61-5
-
Chymosin A, from Escherichia，fcofi K-12。containing the prochymosin A gene Formula
84484-18-4
Request for Quotation