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Hydroxy Pioglitazone

Hydroxy Pioglitazone structure

CAS No:
146062-44-4
Formula:
C19H20N2O4S
Chemical Name:
Hydroxy Pioglitazone
Synonyms:
5-[[4-[2-[5-(1-hydroxyethyl)pyridin-2-yl]ethoxy]phenyl]methyl]-1,3-thiazolidine-2,4-dione;
Categories:
Pharmaceutical Intermediates > Heterocyclic Compound

Description

Hydroxypioglitazone is a member of the class of thiazolidenediones that is the hydroxy derivative of pioglitazone. It has a role as a human xenobiotic metabolite. It is a member of thiazolidinediones, a member of pyridines and an aromatic ether. It derives from a pioglitazone.|Leriglitazone is under investigation in clinical trial NCT03917225 (A Clinical Study to Evaluate the Effect of MIN-102 on the Progression of Friedreich's Ataxia in Male and Female Patients).

Hydroxy Pioglitazone Basic Attributes

Molecular Weight：

372.43800

Exact Mass：

372.11437830

UNII：

K824X25AYA

DSSTox ID：

DTXSID30399914

Characteristics

PSA：

113.82000

XLogP3：

2.97930

Appearance：

Off-White Solid

Density：

1.325 g/cm3

Melting Point：

157-158ºC

Boiling Point：

627.6ºC at 760 mmHg

Refractive Index：

1.628

Vapor Pressure：

1.28E-16mmHg at 25°C

Drug Information

Drug Indication：

Treatment of adrenoleukodystrophy

Metabolism/Metabolites：

5-[(4-{2-[5-(1-hydroxyethyl)pyridin-2-yl]ethoxy}phenyl)methyl]-1,3-thiazolidine-2,4-dione is a known human metabolite of Pioglitazone.

Hydroxy Pioglitazone Use and Manufacturing

Use Classification：

Human drugs -> Rare disease (orphan)|Human Drugs -> EU pediatric investigation plans

Computed Properties

Molecular Weight:372.4
XLogP3:2.5
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:6
Rotatable Bond Count:7
Exact Mass:372.11437830
Monoisotopic Mass:372.11437830
Topological Polar Surface Area:114
Heavy Atom Count:26
Complexity:496
Undefined Atom Stereocenter Count:2
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes

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OH-Pioglitazone (Hydroxy Pioglitazone)

CAS No.: 146062-44-4

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