 Home > Encyclopedia > Resiquimod

Resiquimod

Resiquimod structure

CAS No:
144875-48-9
Formula:
C17H22N4O2
Chemical Name:
Resiquimod
Synonyms:
1H-Imidazo[4,5-c]quinoline-1-ethanol,4-amino-2-(ethoxymethyl)-α,α-dimethyl-;4-Amino-2-(ethoxymethyl)-α,α-dimethyl-1H-imidazo[4,5-c]quinoline-1-ethanol;S 28463;R 848;Resiquimod;1-[4-Amino-2-(ethoxymethyl)-1H-imidazo[4,5-c]quinolin-1-yl]-2-methylpropan-2-ol;Resimiquimod;4-Amino-2-(ethoxymethyl)-1-(2-hydroxyisobutyl)imidazo[4,5-c]quinoline;1-[4-Amino-2-(ethoxymethyl)imidazo[4,5-c]quinolin-1-yl]-2-methylpropan-2-ol;171742-32-8;208711-44-8
Categories:
Pharmaceutical Intermediates > Heterocyclic Compound

Description

Resiquimod is an imidazoquinoline.|A substance being studied in the treatment of some types of skin cancer. When put on the skin, resiquimod causes some immune cells to make certain chemicals that may help them kill tumor cells. It is also being studied to find out if adding it to a tumor vaccine improves the antitumor immune response. It is a type of imidazoquinoline and a type of immunomodulator.|Resiquimod is an imidazoquinolinamine and Toll-like receptor (TLR) agonist with potential immune response modifying activity. Resiquimod exerts its effect through the TLR signaling pathway by binding to and activating TLR7 and 8 mainly on dendritic cells, macrophages, and B-lymphocytes. This induces the nuclear translocation of the transcription activator NF-kB as well as activation of other transcription factors. This may lead to an increase in mRNA levels and subsequent production of cytokines, especially interferon-alpha (INF-a) and other cytokines, thereby enhancing T-helper 1 (Th1) immune responses. In addition, topical application of resiquimod appears to activate Langerhans' cells, leading to an enhanced activation of T-lymphocytes. Due to its immunostimulatory activity, this agent may potentially be useful as a vaccine adjuvant.

Resiquimod Basic Attributes

Molecular Weight：

314.38200

Exact Mass：

314.38

UNII：

V3DMU7PVXF

DSSTox ID：

DTXSID7040603

NCI Thesaurus Code：

C63958

HScode：

2933990090

Characteristics

PSA：

86.19000

XLogP3：

3.05530

Density：

1.28g/cm3

Boiling Point：

553.6ºC at 760mmHg

Flash Point：

288.6ºC

Refractive Index：

1.634

Vapor Pressure：

4.33E-13mmHg at 25°C

Safety Information

GHS Classification：

|Danger|H228 (100%): Flammable solid [Danger Flammable solids]|P210, P240, P241, P261, P264, P270, P271, P280, P301+P310, P302+P352, P304+P340, P305+P351+P338, P312, P321, P330, P332+P313, P337+P313, P362, P370+P378, P403+P233, P405, and P501|The GHS information provided by 1 company from 1 notification to the ECHA C&L Inventory.

Drug Information

Drug Indication：

Investigated for use/treatment in genital herpes.

Mechanism of Action：

Resiquimod is a Toll-like receptor 7 (TLR7) and TLR8 agonist that is a potent inducer of alpha interferon (IFN-alpha) and other cytokines.

MeSH Entry Terms：

R 848

Resiquimod Use and Manufacturing

Use Classification：

Human drugs -> Rare disease (orphan)

Computed Properties

Molecular Weight:314.4
XLogP3:1.3
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:5
Rotatable Bond Count:5
Exact Mass:314.17427596
Monoisotopic Mass:314.17427596
Topological Polar Surface Area:86.2
Heavy Atom Count:23
Complexity:406
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes

Recommended Suppliers of Resiquimod

Dingwang Technology (Wuhan) Co., Ltd. Contact Supplier

CN
5 YRS

Business licensed

Trader Supplier of API,nutrition supplements,plant extract,peptide,HCG

RESIQUIMOD, Resiquimod 99% powder 144875-48-9 Senwayer

CAS No.: 144875-48-9

Grade: Pharmaceutical Grade

Content: 99%

Inquiry
Shaanxi Dideu Medichem Co. Ltd Contact Supplier

CN
4 YRS

Business licensed Certified factory

Manufactory Supplier of Chemical Pesticides,Food Additives,Agrochemicals,Active Pharm Ingredients,Flavors and Fragrances,Chemical Catalyst,Chemical Materials,Chem&Pharm Intermediates,Organic Intermediates,Feed Additive

High Quality 99% Purity of RESIQUIMOD CAS NO 144875-48-9 ISO 9001:2005 REACH Verified Producer

CAS No.: 144875-48-9

Grade: Industrial Grade

Content: 99%

Inquiry
Shandong Ailike New Material Technology Contact Supplier

CN
2 YRS

Business licensed

Trader Supplier of API,Antibiotics,Anti cancer category

Resiquimod cas 144875-48-9

Unit Price: $50 /MT EXW

CAS No.: 144875-48-9

Grade: Pharmaceutical Grade

Content: 99%

Inquiry