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5-[2-ethoxy-5-[4-(2-hydroxyethyl)piperazin-1-yl]sulfonylphenyl]-1-methyl-3-propyl-4H-pyrazolo[4,3-d]pyrimidin-7-one

5-[2-ethoxy-5-[4-(2-hydroxyethyl)piperazin-1-yl]sulfonylphenyl]-1-methyl-3-propyl-4H-pyrazolo[4,3-d]pyrimidin-7-one structure

CAS No:
139755-85-4
Formula:
C23H32N6O5S
Chemical Name:
5-[2-ethoxy-5-[4-(2-hydroxyethyl)piperazin-1-yl]sulfonylphenyl]-1-methyl-3-propyl-4H-pyrazolo[4,3-d]pyrimidin-7-one
Synonyms:
hydroxyhomosildenafil;
Categories:
Pharmaceutical Intermediates > Bulk Drug Intermediates

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Description

A PHOSPHODIESTERASE TYPE-5 INHIBITOR; VASODILATOR AGENT and UROLOGICAL AGENT that is used in the treatment of ERECTILE DYSFUNCTION and PRIMARY PULMONARY HYPERTENSION.

5-[2-ethoxy-5-[4-(2-hydroxyethyl)piperazin-1-yl]sulfonylphenyl]-1-methyl-3-propyl-4H-pyrazolo[4,3-d]pyrimidin-7-one Basic Attributes

Molecular Weight：

504.60200

Exact Mass：

504.21548932

UNII：

80X7B1F6NW

DSSTox ID：

DTXSID60161161

Characteristics

PSA：

142.03000

XLogP3：

1.93000

Density：

1.42g/cm3

Boiling Point：

730.6ºC at 760 mmHg

Flash Point：

395.7ºC

Refractive Index：

1.667

Vapor Pressure：

2.08E-22mmHg at 25°C

Drug Information

MeSH：

Compounds that specifically inhibit PHOSPHODIESTERASE 5. (See all compounds classified as Phosphodiesterase 5 Inhibitors.)|Drugs used in the treatment of urogenital conditions and diseases such as URINARY INCONTINENCE; PROSTATIC HYPERPLASIA; and ERECTILE DYSFUNCTION. (See all compounds classified as Urological Agents.)|Drugs used to cause dilation of the blood vessels. (See all compounds classified as Vasodilator Agents.)

MeSH Entry Terms：

1-((3-(6,7-dihydro-1-methyl-7-oxo-3-propyl-1H-pyrazolo(4,3-d)pyrimidin-5-yl)-4-ethoxyphenyl)sulfonyl)-4-methylpiperazine citrate

Computed Properties

Molecular Weight:504.6
XLogP3:0.8
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:9
Rotatable Bond Count:9
Exact Mass:504.21548932
Monoisotopic Mass:504.21548932
Topological Polar Surface Area:138
Heavy Atom Count:35
Complexity:872
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes

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Guide of 5-[2-ethoxy-5-[4-(2-hydroxyethyl)piperazin-1-yl]sulfonylphenyl]-1-methyl-3-propyl-4H-pyrazolo[4,3-d]pyrimidin-7-one

Description
Basic Attributes
Characteristics
Drug Information
Computed Properties
Latest News
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