4,7-Methano-1H-isoindole-1,3(2H)-dione, hexahydro-2-[4-[4-(2-pyrimidinyl)-1-piperazinyl]butyl]-, (3aR,4S,7R,7aS)-rel-, 2-hydroxy-1,2,3-propanetricarboxylate (1:1)
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![4,7-Methano-1H-isoindole-1,3(2H)-dione, hexahydro-2-[4-[4-(2-pyrimidinyl)-1-piperazinyl]butyl]-, (3aR,4S,7R,7aS)-rel-, 2-hydroxy-1,2,3-propanetricarboxylate (1:1) structure](https://file.echemi.com/fileManage/upload/canonicalSmiles/20220812/6d4d7592697d41fc94f975079ea8f1d7.png "4,7-Methano-1H-isoindole-1,3(2H)-dione, hexahydro-2-[4-[4-(2-pyrimidinyl)-1-piperazinyl]butyl]-, (3aR,4S,7R,7aS)-rel-, 2-hydroxy-1,2,3-propanetricarboxylate (1:1)")
4,7-Methano-1H-isoindole-1,3(2H)-dione, hexahydro-2-[4-[4-(2-pyrimidinyl)-1-piperazinyl]butyl]-, (3aR,4S,7R,7aS)-rel-, 2-hydroxy-1,2,3-propanetricarboxylate (1:1)
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CAS No:
112457-95-1
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Formula:
C21H29N5O2.C6H8O7
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Chemical Name:
4,7-Methano-1H-isoindole-1,3(2H)-dione, hexahydro-2-[4-[4-(2-pyrimidinyl)-1-piperazinyl]butyl]-, (3aR,4S,7R,7aS)-rel-, 2-hydroxy-1,2,3-propanetricarboxylate (1:1)
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Synonyms:
4,7-Methano-1H-isoindole-1,3(2H)-dione,hexahydro-2-[4-[4-(2-pyrimidinyl)-1-piperazinyl]butyl]-,(3aR,4S,7R,7aS)-rel-,2-hydroxy-1,2,3-propanetricarboxylate (1:1);4,7-Methano-1H-isoindole-1,3(2H)-dione,hexahydro-2-[4-[4-(2-pyrimidinyl)-1-piperazinyl]butyl]-,(3aα,4β,7β,7aα)-,2-hydroxy-1,2,3-propanetricarboxylate (1:1);SM 3997;Tandospirone citrate;Sediel
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CAS No:
Description
Tandospirone citrate is a citrate salt of tandospirone , comprising equimolar amounts of citric acid and tandospirone. It is an anxiolytic drug used in the treatment of anxiety disorders. It has a role as an anxiolytic drug and an antidepressant. It contains a tandospirone(1+).
4,7-Methano-1H-isoindole-1,3(2H)-dione, hexahydro-2-[4-[4-(2-pyrimidinyl)-1-piperazinyl]butyl]-, (3aR,4S,7R,7aS)-rel-, 2-hydroxy-1,2,3-propanetricarboxylate (1:1) Basic Attributes
575.61100
575.25912777 g/mol
0R8E9BWM4J
2933990090
Drug Information
Agents that alleviate ANXIETY, tension, and ANXIETY DISORDERS, promote sedation, and have a calming effect without affecting clarity of consciousness or neurologic conditions. ADRENERGIC BETA-ANTAGONISTS are commonly used in the symptomatic treatment of anxiety but are not included here. (See all compounds classified as Anti-Anxiety Agents.)|Endogenous compounds and drugs that bind to and activate SEROTONIN RECEPTORS. Many serotonin receptor agonists are used as ANTIDEPRESSANTS; ANXIOLYTICS; and in the treatment of MIGRAINE DISORDERS. (See all compounds classified as Serotonin Receptor Agonists.)
3a,4,7,7a-hexahydro-2-(4-(4-(2-pyrimidinyl)-1-piperazinyl)butyl)-4,7-methano-1H-isoindole-1,3(2H)-dione
Computed Properties
Molecular Weight:575.6
Hydrogen Bond Donor Count:4
Hydrogen Bond Acceptor Count:13
Rotatable Bond Count:11
Exact Mass:575.25912777
Monoisotopic Mass:575.25912777
Topological Polar Surface Area:202
Heavy Atom Count:41
Complexity:799
Defined Atom Stereocenter Count:4
Covalently-Bonded Unit Count:2
Compound Is Canonicalized:Yes
Drug Function and Efficacy
Tandospirone is an antianxiety drug that selectively acts on the 5-HT1A receptor in the brain. Animal experiments have shown that tandospirone has comparable antianxiety effects to diazepam. Animal model experiments on psychosomatic diseases have shown that tandospirone can inhibit the pressor response caused by hypothalamic stimulation and the increase in plasma renin activity caused by electric shock stress, and inhibit the occurrence of gastric ulcers caused by psychological stress and the loss of appetite caused by forced immersion stress.
Registered Holders
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Luzhou Kereide Pharmaceutical Co., Ltd.
Active
China
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Marubeni Pharmaceuticals (Suzhou) Co., Ltd.
Active
China
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Sichuan Yinodabo Pharmaceutical Technology Co., Ltd.
Active
China
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