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HYDROXYNAPHTHOL BLUE

HYDROXYNAPHTHOL BLUE structure

CAS No:
63451-35-4
Formula:
C20H15N2NaO11S3
Chemical Name:
HYDROXYNAPHTHOL BLUE
Synonyms:
7-naphthalenedisulfonicacid,3-hydroxy-4-[(2-hydroxy-4-sulfo-1-naphthalenyl)azo]-trisodiumsalt;HYDROXYNAPHTHOL BLUE;HYDROXYNAPHTHOL BLUE INDICATOR;HYDROXYNAPHTHOL BLUE TRISODIUM SALT;CALVER(R) 2 CALCIUM INDICATOR;3-HYDROXY-4-(2-HYDROXY-4-SULFO-1-NAPHTHYLAZO)NAPHTHALENE-2,7-DISULFONIC ACID TRISODIUM SALT;1-(2-HYDROXY-4-SULFO-1-NAPHTHYLAZO)-2-NAPHTHOL-3,6-DISULFONIC ACID TRISODIUM SALT;1-(2-NAPHTHOLAZO-3,6-DISULFONIC ACID)-2-NAPHTHOL-4-SULFONIC ACID DISODIUM SALT
Categories:
Chemical Reagents > Organic Reagents

Description

Hydroxynaphthol blue, a well-known pH indicator in the field of biomedicine, is employed to accurately quantify pH fluctuations in various biological specimens. Besides, its utility extends to serving as a colorimetric reagent, notably in laboratory settings, aiding in the identification of select pharmaceuticals and ailments.

blue crystalline powder

The crude material is treated with hot EtOH to remove soluble impurities, then dissolve in 20% aqueous MeOH and chromatographed on a cellulose powder column with propanol/EtOH/water (5:5:4) as eluent. The upper of three zones was eluted to give the pure dye which is precipitated as the monosodium salt trihydrate by adding conc HCl to the concentrated eluate [Ito & Ueno Analyst 95 583 1970]. It can be converted to the trisodium salt wih the calculated amount of alkali. Indigocarmine (2[1,3-dihydro-3-oxo-5-sulfo-2H -indol-2-ylidene]-2,3-dihydro-3-oxo-1H -

HYDROXYNAPHTHOL BLUE Basic Attributes

Molecular Weight：

578.51

Exact Mass：

619.92180554 g/mol

EC Number：

264-197-7

TSCA：

TSCA listed

DSSTox ID：

DTXSID8069852

Color/Form：

Dark Gray

HScode：

2927 00 00

Characteristics

PSA：

261.92000

XLogP3：

5.77430

Appearance：

gray to purple solid.

Water Solubility：

340g/L

PH：

2-3 (10g/l, H2O, 20℃)

Critical Temperature & Pressure：

Store at +15°C to +30°C.

Safety Information

wgk germany：

WGK 3 highly water endangering

hazard class code：

safety instructions：

26-36

Marks：

Stability/Shelf Life：

Stable. Incompatible with strong oxidizing agents.

Hazard Statements：

36/37/38

GHS Classification：

|Warning|H315 (97.5%): Causes skin irritation [Warning Skin corrosion/irritation]|P261, P264, P271, P280, P302+P352, P304+P340, P305+P351+P338, P312, P321, P332+P313, P337+P313, P362, P403+P233, P405, and P501|Aggregated GHS information provided by 40 companies from 3 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.

Drug Information

MeSH Entry Terms：

hydroxy naphthol blue

HYDROXYNAPHTHOL BLUE Use and Manufacturing

Uses

Hydroxynapthol Blue is a pharmaceutical dye used in colorimetric analyses.

Manufacturing Info：

2,7-Naphthalenedisulfonic acid, 3-hydroxy-4-[2-(2-hydroxy-4-sulfo-1-naphthalenyl)diazenyl]-, sodium salt (1:3): ACTIVE

Computed Properties

Molecular Weight:620.5
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:13
Rotatable Bond Count:2
Exact Mass:619.92180554
Monoisotopic Mass:619.92180554
Topological Polar Surface Area:262
Heavy Atom Count:39
Complexity:1120
Covalently-Bonded Unit Count:4
Compound Is Canonicalized:Yes

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Hydroxy Naphthol Blue 63451-35-4

CAS No.: 63451-35-4

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