Dicyclomine

309.5 g/mol

309.49

201-009-4

4KV4X8IF6V

404381

DTXSID1022926

C61720

A - Alimentary tract and metabolism

29.5 Ų

5.5

165-166

142-143 °C @ Press: 0.5 Torr

SOL IN WATER ABOUT 25% /HYDROCHLORIDE/|1 G IN 13 ML WATER, 5 ML ALC, 2.5 ML CHLOROFORM, 770 ML ETHER; INSOL IN ALKALINE AQ MEDIUM /HCL/|3.27e-03 g/L

MP 164-166 °C /HYDROCHLORIDE/|PRACTICALLY ODORLESS & HAS VERY BITTER TASTE /HYDROCHLORIDE/|CRYSTALS FROM BUTANONE /HYDROCHLORIDE/|FINE, WHITE, CRYSTALLINE POWDER /HYDROCHLORIDE/

STABLE IN AIR & TO MODERATE HEAT /HYDROCHLORIDE/

|Warning|H302 (100%): Harmful if swallowed [Warning Acute toxicity, oral]|P264, P270, P301+P312, P330, and P501|The GHS information provided by 1 company from 1 notification to the ECHA C&L Inventory.

Patients experiencing an overdose may present with headache, nausea, vomiting, blurred vision, dilated pupils, dizziness, dry mouth, difficulty swallowing, CNS stimulation, as well as hot, dry skin. Treat patients with gastric lavage, emetics, activated charcoal, sedatives for excitement, and a cholinergic agent if indicated. The oral LD50 in mice is 625mg/kg.

Like other anticholinergic agents, dicyclomine has not been linked to episodes of liver enzyme elevations or clinically apparent liver injury. The metabolism of dicyclomine is not well defined but it is likely metabolized by the liver.

...ANTICHOLINERGIC AGENTS, SUCH AS...DICYCLOMINE...WOULD BE EXPECTED TO INTERACT WITH DIGOXIN...

Data regarding plasma protein binding of dicyclomine is not readily available.

Dicyclomine is indicated for the treatment of functional bowel disorder and irritable bowel syndrome.|FDA Label

Dicyclomine is an anticholinergic agent used to treat gastrointestinal conditions such as acid peptic disease and irritable bowel syndrome. Dicyclomine has not been implicated in causing liver enzyme elevations or clinically apparent acute liver injury.

Anticholinergic Agents

Muscarinic Antagonists; Parasympatholytics|...OFTEN CLASSIFIED WITH ANTIMUSCARINIC AGENTS AS "ANTISPASMODICS," DO NOT PROPERLY BELONG TO GROUP OF ANTIMUSCARINIC AGENTS. ...DICYCLOMINE HYDROCHLORIDE, VSP-DECR SPASM OF GI TRACT, BILIARY TRACT, URETER, & UTERUS WITHOUT PRODUCING CHARACTERISTIC ATROPINIC EFFECTS ON SALIVARY, SWEAT, OR GI GLANDS, EYE, CV SYSTEM... /HCL/|IT DECR MOTILITY BUT DOES NOT SUPPRESS GASTRIC SECRETION. IT IS USED IN TREATMENT OF IRRITABLE COLON, SPASTIC CONSTIPATION, MUCOUS COLITIS, SPASTIC COLITIS, PYLOROSPASM, & BILIARY DYSKINESIA. IN TREATMENT OF PEPTIC ULCER IT IS USED TO DELAY GASTRIC EMPTYING. /HYDROCHLORIDE/|ANTICHOLINERGIC /HYDROCHLORIDE/

DICYCLOMINE SHOULD BE USED CAUTIOUSLY IN PT WITH PROSTATIC HYPERTROPHY, BLADDER NECK OBSTRUCTION, PYLORIC OBSTRUCTION, & CARDIOSPASM. EVEN THOUGH IT DOES NOT APPEAR TO RAISE INTRAOCULAR PRESSURE IN NARROW-ANGLE GLAUCOMA, IT IS ADVISABLE TO MONITOR PRESSURE OF SUCH PT.|CLINICAL USE OF.../BENTYL/ HAS BEEN DISAPPOINTING.|A 3-YR-OLD MALE INGESTED APPROX 100 TABLETS OF BENDECTIN & DEVELOPED TONIC-CLONIC SEIZURES FOLLOWED BY CARDIAC ARREST. ANALYSIS YIELDED HIGH LEVELS OF DOXYLAMINE, DICYCLOMINE & PYRIDOXINE. DOXYLAMINE APPEARS TO BE TOXIC CONSTITUENT.

Dicyclomine is an anticholinergic drug used to relax the smooth muscles of the intestines. It's duration of action is not especially long as it is usually taken 4 times daily with individual doses of 20-40mg orally or 10-20mg by intramuscular injection. Dicyclomine should not be administered intravenously.

Agents that inhibit the actions of the parasympathetic nervous system. The major group of drugs used therapeutically for this purpose is the MUSCARINIC ANTAGONISTS. (See all compounds classified as Parasympatholytics.)|Drugs that bind to but do not activate MUSCARINIC RECEPTORS, thereby blocking the actions of endogenous ACETYLCHOLINE or exogenous agonists. Muscarinic antagonists have widespread effects including actions on the iris and ciliary muscle of the eye, the heart and blood vessels, secretions of the respiratory tract, GI system, and salivary glands, GI motility, urinary bladder tone, and the central nervous system. (See all compounds classified as Muscarinic Antagonists.)

The bioavailability of dicyclomine has not been determined, though it is likely well absorbed as the primary route of elimination is in the urine. Dicyclomine has a T_max of 1-1.5h.|Dicyclomine is 79.5% eliminated in the urine and 8.4% in the feces.|The volume of distribution for a 20mg oral dose is 3.65L/kg.|Data regarding the clearance of dicyclomine is not readily available.

The metabolism of dicyclomine has not been well researched.

The mean plasma elimination half life is approximately 1.8 hours.

Dicyclomine achieves its action partially through direct antimuscarinic activity of the M1 and M2 receptors, and partially through antagonism of bradykinin and histamine. Dicyclomine non-competitively inhibits the action of bradykinin and histamine, resulting in direct action on the smooth muscle, and decreased strength of contractions seen in spasms of the ileum.|...MAJOR ACTION APPEARS TO BE NONSPECIFIC DIRECT RELAXANT ACTION ON SMOOTH MUSLCE RATHER THAN COMPETITIVE ANTAGONISM OF ACH.

SIDE EFFECTS OF DICYCLOMINE INCL DIZZINESS, FEELING OF ABDOMINAL FULLNESS, & DRY MOUTH. CONSTIPATION, BLURRED VISION, FATIGUE, SEDATION, NAUSEA, VOMITING, HEADACHE, IMPOTENCE, URINARY RETENTION, & RASH OCCUR RARELY.|THERE IS ONE REPORT THAT WHEN PT UNDER TREATMENT FOR GLAUCOMA OF UNSPECIFIED TYPE WERE GIVEN 10 MG OF DICYCLOVERINE HYDROCHLORIDE ORALLY, THEY HAD RISE OF 3-10 MM HG FOR 2-3 HR. IN MOST CASES NO RISE OF OCULAR PRESSURE HAS BEEN FOUND, REGARDLESS OF TYPE OF GLAUCOMA. /HYDROCHLORIDE/|INCIDENCE OF BIRTH DEFECTS IN OFFSPRING OF WOMEN WHO TOOK BENDECTIN CONTAINING 10 MG DICYCLOMINE HCL DURING PREGNANCY WAS INVESTIGATED. BIRTHS WERE TRACED FOR 2,298 PT & INCIDENCE OF DEFECTS COMPARED WITH THOSE IN RELEVANT POPULATIONS. NO EVIDENCE OF TERATOGENICITY FOUND.

Bentyl

DICYCLOMINE HYDROCHLORIDE, USP, BENTYL; CAPSULES: 10 MG; TABLETS: 20 MG; SYRUP: 2 MG/ML, 10 TO 20 MG. ALSO AVAILABLE IN SOLN OR AS POWDER FOR DISSOLUTION FOR INJECTION. /HYDROCHLORIDE/

[1,1'-Bicyclohexyl]-1-carboxylic acid, 2-(diethylamino)ethyl ester: INACTIVE

GLC METHOD AFFORDED SATISFACTORY SENSITIVITY & REPRODUCIBILITY & ALLOWED DIRECT SIMULTANEOUS DETECTION OF SEVERAL CONSTITUENTS IN MULTICOMPONENT SYSTEM.|COMPUTERIZED GAS-LIQ CHROMATOGRAPHIC METHOD FOR CONTENT UNIFORMITY ANALYSIS OF DICYCLOMINE HYDROCHLORIDE CAPSULES & TABLETS. GLC RESULTS WERE COMPARABLE (WITHIN 1%) TO THOSE OBTAINED USING USP PROCEDURE.

GLC METHOD SUITABLE FOR DETERMINING BLOOD LEVELS FOLLOWING NORMAL THERAPEUTIC DOSES.

Human Drugs -> FDA Approved Drug Products with Therapeutic Equivalence Evaluations (Orange Book) -> Active Ingredients