2-(1H-Imidazol-5-yl)ethyl carbamimidothioate
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2-(1H-Imidazol-5-yl)ethyl carbamimidothioate
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CAS No:
102203-18-9
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Formula:
C6H10N4S
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Chemical Name:
2-(1H-Imidazol-5-yl)ethyl carbamimidothioate
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Synonyms:
Carbamimidothioic acid,2-(1H-imidazol-5-yl)ethyl ester;Carbamimidothioic acid,2-(1H-imidazol-4-yl)ethyl ester;2-(1H-Imidazol-5-yl)ethyl carbamimidothioate;VUF 8325;Imetit;SKF 91105;[[2-(1H-Imidazol-5-yl)ethyl]sulfanyl]methanimidamide;[[2-(1H-Imidazol-4-yl)ethyl]sulfanyl]methanimidamide;2-[2-(1H-Imidazol-4-yl)-ethyl]-isothiourea
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CAS No:
Description
Imetit is an imidothiocarbamic ester that consists of isothiourea in which the thiol hydrogen is substituted by a 2-(imidazol-4-yl)ethyl group. An extremely potent, high affinity agonist at H3 and H4 receptors (Ki values are 0.3 and 2.7 nM respectively). Induces shape change in eosinophils with an EC50 of 25 nM. Centrally active following systemic administration. It has a role as a H3-receptor agonist and a H4-receptor agonist. It is a member of imidazoles and an imidothiocarbamic ester. It is a conjugate base of an imetit(2+).
2-(1H-Imidazol-5-yl)ethyl carbamimidothioate Basic Attributes
170.24 g/mol
170.24
677MJ4VPZC
DTXSID8043737
Drug Information
Drugs that bind to and activate histamine receptors. Although they have been suggested for a variety of clinical applications histamine agonists have so far been more widely used in research than therapeutically. (See all compounds classified as Histamine Agonists.)
2-(1H-imidazol-5-yl)ethyl imidothiocarbamate
Computed Properties
Molecular Weight:170.24
XLogP3:0.2
Hydrogen Bond Donor Count:3
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:4
Exact Mass:170.06261751
Monoisotopic Mass:170.06261751
Topological Polar Surface Area:104
Heavy Atom Count:11
Complexity:139
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes
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