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Intoplicine

Intoplicine structure

CAS No:
125974-72-3
Formula:
C21H24N4O
Chemical Name:
Intoplicine
Synonyms:
7H-Benzo[e]pyrido[4,3-b]indol-3-ol,11-[[3-(dimethylamino)propyl]amino]-8-methyl-;11-[[3-(Dimethylamino)propyl]amino]-8-methyl-7H-benzo[e]pyrido[4,3-b]indol-3-ol;Intoplicine
Categories:
Pharmaceutical Intermediates > Bulk Drug Intermediates

Description

Intoplicine is a pyridoindole.|Intoplicine has been used in trials studying the treatment of Unspecified Adult Solid Tumor, Protocol Specific.|Intoplicine is a benzopyridoindole derivative with antineoplastic property. Intoplicine inhibits activities of both topoisomerase I and II via intercalating DNA helix, thereby hindering the movements of enzymes along DNA molecules during DNA transcription and replication, respectively. Furthermore, this agent stabilizes DNA-enzyme complexes during unwinding processes by both topoisomerases, leading to double- and single-stranded DNA breaks. Consequently, these effects bring about cell growth inhibition and apoptosis of tumor cells.

Intoplicine Basic Attributes

Molecular Weight：

348.4 g/mol

Exact Mass：

348.44

UNII：

FB2CIN6HMI

DSSTox ID：

DTXSID80155022

NCI Thesaurus Code：

C1495

Characteristics

PSA：

64.2 Å²

Melting Point：

216-218 °C

Drug Information

MeSH Entry Terms：

11-(3-dimethylaminopropylamino)-3-hydroxy-8-methyl-7H-benzo(e)pyrido(4,3-b)indole dimethanesulfonate

Computed Properties

Molecular Weight:348.4
XLogP3:4.3
Hydrogen Bond Donor Count:3
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:5
Exact Mass:348.19501140
Monoisotopic Mass:348.19501140
Topological Polar Surface Area:64.2
Heavy Atom Count:26
Complexity:473
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes