(+/-)5-HEPE
-
(+/-)5-HEPE
structure -
-
CAS No:
83952-40-3
-
Formula:
C20H30O3
-
Chemical Name:
(+/-)5-HEPE
-
Synonyms:
(+/-)5-HEPE;(+/-)-5-HYDROXY-6E,8Z,11Z,14Z,17Z-EICOSAPENTAENOIC ACID;(+/-)5-HYDROXYEICOSA-6E,8Z,11Z,14Z,17Z-PENTAENOIC ACID;5-hydroxy-6,8,11,14,17-eicosapentaenoic acid;FTAGQROYQYQRHF-FCWZHQICSA-N;6,8,11,14,17-Eicosapentaenoic acid, 5-hydroxy-, (6E,8Z,11Z,14Z,17Z)-;5-Hydroxy-6(E),8(Z),11(Z),14(Z),17(Z)-EPA
-
CAS No:
Description
(±)5-HEPE is produced by non-enzymatic oxidation of EPA. It contains equal amounts of 5(S)-HEPE and 5(R)-HEPE. The biological activity of (±)5-HEPE is likely mediated by one of the individual isomers, most commonly the 5(S) isomer in mammalian systems. EPA can be metabolized to 5-HEPE in human and bovine neutrophils, and human eosinophils, which is further metabolized to 5-oxoEPE and LTB5. The 5-series metabolites of EPA, namely 5-HEPE, 5-oxoEPE, and LTB5, have significantly decreased biological effects compared to the arachidonic acid-derived metabolites.
ChEBI: 5-HEPE is a hydroxyicosapentaenoic acid that consists of 6E,8Z,11Z,14Z,17Z-icosapentaenoic acid with the hydroxy group located at position 5. It has a role as a mouse metabolite. It is a conjugate acid of a 5-HEPE(1-).
Characteristics
57.53000
4.96350
0.997±0.06 g/cm3(Predicted)
488.0±45.0 °C(Predicted)
263.1ºC
4.67±0.10(Predicted)
Store at -20°C
(+/-)5-HEPE Use and Manufacturing
(±)5-HEPE is produced by non-enzymatic oxidation of EPA. It contains equal amounts of 5(S)-HEPE and 5(R)-HEPE. The biological activity of (±)5-HEPE is likely mediated by one of the individual isomers, most commonly the 5(S) isomer in mammalian systems. EPA can be metabolized to 5-HEPE in human and bovine neutrophils, and human eosinophils, which is further metabolized to 5-oxoEPE and LTB5. The 5-series metabolites of EPA, namely 5-HEPE, 5-oxoEPE, and LTB5, have significantly decreased biological effects compared to the arachidonic acid-derived metabolites.
Request for Quotation