Nolatrexed dihydrochloride
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Nolatrexed dihydrochloride
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CAS No:
152946-68-4
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Formula:
C14H14Cl2N4OS
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Chemical Name:
Nolatrexed dihydrochloride
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Synonyms:
Nolatrexed hydrochloride;Nolatrexed (AG-337);3,4-Dihydro-2-amino-6-methyl-4-oxo-5-(4-pyridylthio)-quinazoline dihydrochloride Nolatrexed (AG-337);Nolatrexed dihydrochloride 3,4-Dihydro-2-amino-6-methyl-4-oxo-5-(4-pyridylthio)-quinazoline dihydrochloride;Nolatrexed 2hydrochloride;NOLATREXED DIHYDROCHLORIDE;AG 337;2-Amino-6-methyl-5-(4-pyridinylthio)-4(1H)-quinazolinone Hydrochloride
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CAS No:
Description
Nolatrexed Dihydrochloride is the dihydrochloride salt of nolatrexed, a water-soluble lipophilic quinazoline folate analog with antineoplastic activity. Nolatrexed occupies the folate binding site of thymidylate synthase, resulting in inhibition of thymidylate synthase activity and thymine nucleotide synthesis with subsequent inhibition of DNA replication, DNA damage, S-phase cell cycle arrest, and caspase-dependent apoptosis. This agent also exhibits radiosensitizing activity.
Tan Solid
Nolatrexed dihydrochloride Basic Attributes
357.26
356.0265376
680-267-3
1XA69O733O
DTXSID4046810
C1577
Off-White to Pale Yellow
Characteristics
301-3020C
H2O: 2mg/mL, clear
4.1; 5.9; 9.8(at 25℃)
Hygroscopic, -20°C Freezer, Under Inert Atmosphere
Drug Information
Antimetabolites that are useful in cancer chemotherapy. (See all compounds classified as Antimetabolites, Antineoplastic.)|Compounds or agents that combine with an enzyme in such a manner as to prevent the normal substrate-enzyme combination and the catalytic reaction. (See all compounds classified as Enzyme Inhibitors.)|Inhibitors of the enzyme, dihydrofolate reductase (TETRAHYDROFOLATE DEHYDROGENASE), which converts dihydrofolate (FH2) to tetrahydrofolate (FH4). They are frequently used in cancer chemotherapy. (From AMA, Drug Evaluations Annual, 1994, p2033) (See all compounds classified as Folic Acid Antagonists.)
3,4-dihydro-2-amino-6-methyl-4-oxo-5-(4-pyridylthio)quinazoline dihydrochloride
Nolatrexed dihydrochloride Use and Manufacturing
Antifolate thymidylate synthase inhibitor. Antineoplastic.
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