1-TERT-BUTOXY-2-PROPANOL

132.2

132.20

406-180-0

1615

1993

TSCA listed

DTXSID8025967

Colorless to Almost colorless

2905.19.9090

log Kow = 0.87 /Estimated/

0.874 g/mL at 20 °C(lit.)

-56°C(lit.)

143-145 °C(lit.)

112 °F (NTP, 1992)|44.4 °C o.c.

n20/D1.413(lit.)

Soluble in water

4.8 mm Hg at 68 °F (NTP, 1992)|4.7 mm Hg at 20 °C|Vapor pressure, kPa at 20 °C: 0.64

4.6 (NTP, 1992) (Relative to Air)|4.56 (Air = 1)|Relative vapor density (air = 1): 4.6

14.51±0.20(Predicted)

2.1×100mol/(m3Pa) at 25℃, HSDB (2015)

Freezing point = -56 °C|Distillation range = 145-155 °C|Hydroxyl radical reaction rate constant = 1.7X10-11 cu-cm/molecule sec at 25 °C /Estimated/

Highly flammable. Sensitive to heat and prolonged exposure to air. Water soluble.

Alcohols and Polyols

Highly Flammable

1-TERT-BUTOXY-2-PROPANOL is incompatible with acids, oxidizing agents, oxygen (prolonged contact), water and dehydrating agents. .

373 °C

III

3.2

1

Xi

26-39

UB3772000

10-41

SRP: The most favorable course of action is to use an alternative chemical product with less inherent propensity for occupational exposure or environmental contamination. Recycle any unused portion of the material for its approved use or return it to the manufacturer or supplier. Ultimate disposal of the chemical must consider: the material's impact on air quality; potential migration in soil or water; effects on animal, aquatic, and plant life; and conformance with environmental and public health regulations.

UN 1987 3/PG 3

1-TERT-BUTOXY-2-PROPANOL is combustible.

|Danger|H226: Flammable liquid and vapor [Warning Flammable liquids]|P210, P233, P240, P241, P242, P243, P280, P303+P361+P353, P305+P351+P338, P310, P370+P378, P403+P235, and P501|H226 (100%): Flammable liquid and vapor [Warning Flammable liquids]|Aggregated GHS information provided by 41 companies from 2 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.|Aggregated GHS information provided by 196 companies from 3 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.|Warning|P210, P233, P240, P241, P242, P243, P261, P264, P271, P280, P303+P361+P353, P304+P340, P305+P351+P338, P312, P337+P313, P370+P378, P403+P233, P403+P235, P405, and P501|P201, P202, P210, P233, P240, P241, P242, P243, P260, P261, P264, P271, P280, P281, P303+P361+P353, P304+P340, P305+P351+P338, P308+P313, P312, P314, P337+P313, P370+P378, P403+P233, P403+P235, P405, and P501

Fires involving this material can be controlled with a dry chemical, carbon dioxide or Halon extinguisher. A water spray may also be used. (NTP, 1992)|Use water spray, powder, alcohol-resistant foam, carbon dioxide.

Excerpt from ERG Guide 128 [Flammable Liquids (Water-Immiscible)]: As an immediate precautionary measure, isolate spill or leak area for at least 50 meters (150 feet) in all directions. LARGE SPILL: Consider initial downwind evacuation for at least 300 meters (1000 feet). FIRE: If tank, rail car or tank truck is involved in a fire, ISOLATE for 800 meters (1/2 mile) in all directions; also, consider initial evacuation for 800 meters (1/2 mile) in all directions. (ERG, 2016)

SMALL SPILLS AND LEAKAGE: If you should spill this chemical, use absorbent paper to pick up all liquid spill material. Seal the absorbent paper, as well as any of your clothing which may be contaminated, in a vapor-tight plastic bag for eventual disposal. Wash any surfaces you may have contaminated with a soap and water solution. Do not reenter the contaminated area until the Safety Officer (or other responsible person) has verified that the area has been properly cleaned. STORAGE PRECAUTIONS: You should keep this material in a tightly closed container under an inert atmosphere, and store it at refrigerated temperatures. (NTP, 1992)

RECOMMENDED RESPIRATOR: Where the neat test chemical is stored, weighed and diluted, wear an approved half face respirator equipped with an organic vapor/acid gas cartridge (specific for organic vapors, HCl, acid gas and SO2) with a dust/mist filter. (NTP, 1992)

Explosive limits , vol% in air: 1.8-6.8

SRP: The scientific literature for the use of contact lenses in industry is conflicting. The benefit or detrimental effects of wearing contact lenses depend not only upon the substance, but also on factors including the form of the substance, characteristics and duration of the exposure, the uses of other eye protection equipment, and the hygiene of the lenses. However, there may be individual substances whose irritating or corrosive properties are such that the wearing of contact lenses would be harmful to the eye. In those specific cases, contact lenses should not be worn. In any event, the usual eye protection equipment should be worn even when contact lenses are in place.

It is slightly irritating to skin, but pure propylene glycol mono-tert-butyl ether can be severely irritating to eyes.

Remove all ignition sources. Personal protection: face shield. Collect leaking and spilled liquid in sealable containers as far as possible. Absorb remaining liquid in sand or inert absorbent. Then store and dispose of according to local regulations.

Fireproof. Cool. Separated from strong oxidants.

No indication can be given about the rate at which a harmful concentration of this substance in the air is reached on evaporation at 20 °C.

The substance is severely irritating to the eyes.

NO open flames, NO sparks and NO smoking. NO contact with strong oxidizing agents. Above 44 °C use a closed system, ventilation and explosion-proof electrical equipment.

Use ventilation, local exhaust or breathing protection.

Protective gloves.

Wear safety goggles.

LD50 Rat (Sprague-Dawley) oral 3771 mg/kg

Propylene glycol mono-t-butyl ether is used as a solvent for all-purpose cleaners, electronic chemicals, inks, adhesives, nail polish lacquers, and other water-reducible coatings. Propylene glycol mono-t-butyl ether was nominated for study by the United States Consumer Product Safety Commission because of its widespread use, potential for human exposure, and the lack of adequate toxicological, chronic toxicity, and carcinogenicity information. Male and female F344/N rats and B6C3F1 mice were exposed to propylene glycol mono-t-butyl ether (at least 99% pure) by inhalation for 2 weeks, 3 months, or 2 years. The chemical structure of propylene glycol mono-t-butyl ether indicated a potential to induce alpha2u-globulin nephropathy, a male-specific renal syndrome characterized by the accumulation of hyaline droplets in the proximal tubule epithelium of F344/N rats. Thus, male NBR rats, which do not develop this condition, were exposed to propylene glycol mono-t-butyl ether concurrently with F344/N rats for 2 weeks for comparison of renal lesion development. Genetic toxicology studies were conducted in Salmonella typhimurium, cultured Chinese hamster ovary cells, and mouse peripheral blood erythrocytes. 2-WEEK STUDY IN RATS: Groups of five male and five female F344/N rats and five male NBR rats were exposed to 0, 75, 150, 300, 600, or 1,200 ppm propylene glycol mono-t-butyl ether vapor 6 hours per day, 5 days per week for 16 days. All rats survived to the end of the study, and mean body weights of exposed groups were similar to those of the chamber controls. Renal toxicity studies were performed in male F344/N and NBR rats. The number of cells labeled with proliferating cell nuclear antigen and the labeling index (number of labeled nuclei/total nuclei) in the left kidney of 1,200 ppm male F344/N rats were significantly greater than those in the chamber controls. No significant differences in labeling indices were noted in NBR rats. Kidney weights of 600 ppm male F344/N rats were significantly increased. Liver weights of male and female F344/N rats exposed to 600 and 1,200 ppm and male NBR rats exposed to 1,200 ppm were significantly increased. 2-WEEK STUDY IN MICE: Groups of five male and five female B6C3F1 mice were exposed to 0, 75, 150, 300, 600, or 1,200 ppm propylene glycol mono-t-butyl ether 6 hours per day, 5 days per week for 17 days. All mice survived to the end of the study. Mean body weights of 1,200 ppm female mice were significantly greater than those of the chamber control group. Liver weights of 600 and 1,200 ppm males and of 300 ppm or greater females were significantly increased. 3-MONTH STUDY IN RATS: Groups of 25 male and 20 female F344/N rats were exposed to 0, 75, 150, 300, 600, or 1,200 ppm propylene glycol mono-t-butyl ether vapor 6 hours per day, 5 days per week for 2 (five male renal toxicity rats), 4 or 6 (10 male and 10 female clinical pathology rats), or 14 (10 core study rats) weeks. All core study rats survived to the end of the study. Mean body weight gains of 1,200 ppm males and 600 and 1,200 ppm females were significantly increased. At week 12, urinalysis results indicated that exposure of rats to propylene glycol mono-t-butyl ether caused increases in urine volume, glucose and protein concentrations, and the activities of aspartate aminotransferase in males and increases in the activities of lactate dehydrogenase and N-acetyl-beta-D-glucosaminidase in males and females. Renal toxicity studies were performed on male rats sacrificed at 2 and 6 weeks and at the end of the study. In kidney tissue examined for cell proliferation, the numbers of PCNA-labeled cells and labeling indices in exposed groups of rats were generally significantly greater than those of the chamber controls at all three time points. Exposure-related increases in alpha2u-globulin concentrations in males occurred throughout the study. Kidney weights of all exposed groups of males and of 300 ppm or greater females and liver weights of all exposed groups of males and 600 ppm or greater females were increased. Incidences of renal tubule regeneration and granular casts in the medulla of the kidney in exposed rats were increased, and the severities of hyaline droplets generally increased with increasing exposure concentration. 3-MONTH STUDY IN MICE: Groups of 10 male and 10 female B6C3F1 mice were exposed to 0, 75, 150, 300, 600, or 1,200 ppm propylene glycol mono-t-butyl ether 6 hours per day, 5 days per week for 14 weeks. All mice survived to the end of the study. Final mean body weights of 300 and 1,200 ppm males and mean body weight gains for 150, 300, and 1,200 ppm males were significantly less than those of the chamber control group. Liver weights of 600 and 1,200 ppm males and females were significantly increased. The estrous cycle length of 1,200 ppm females was significantly increased. The incidences of minimal to mild centrilobular hypertrophy of the liver were significantly increased in 600 ppm males and 1,200 ppm males and females. The incidence of minimal squamous metaplasia of the respiratory epithelium of the nose was significantly increased in 1,200 ppm males. 2-YEAR STUDY IN RATS: Groups of 50 male and 50 female F344/N rats were exposed to 0, 75, 300, or 1,200 ppm propylene glycol mono-t-butyl ether vapor 6 hours per day, 5 days per week for 104 weeks. Survival of 300 ppm males was less than that of the chamber controls. Mean body weights of 1,200 ppm males and females were less than those of the chamber controls during the second year of the study. In 1,200 ppm males and females the excretion of propylene glycol mono-t-butyl ether glucuronide in urine, expressed as the metabolite to creatinine ratios, were generally significantly less than those in the groups exposed to 75 or 300 ppm. Incidences of renal tubule hyperplasia, renal tubule hyaline droplet accumulation, papilla mineralization, and transitional epithelial hyperplasia were increased in most exposed groups of males. Marginally increased incidences of renal tubule adenoma and adenoma or carcinoma (combined) occurred in 300 and 1,200 ppm males. The severities of chronic nephropathy increased with increasing exposure concentration in males and females and were significantly increased in all exposed groups of males and in 1,200 ppm females. The incidences of hepatocellular adenoma occurred with a positive trend in male rats. The incidences of basophilic foci of the liver were significantly increased in all exposed groups of males; the incidence of clear foci of the liver was significantly increased in 1,200 ppm females. The incidences of hyaline degeneration of the olfactory epithelium in all exposed groups of males and females and the incidence of corneal mineralization in 1,200 ppm females were significantly increased. 2-YEAR STUDY IN MICE: Groups of 50 male and 50 female B6C3F1 mice were exposed to 0, 75, 300, or 1,200 ppm propylene glycol mono-t-butyl ether vapor 6 hours per day, 5 days per week for 104 weeks. Survival of exposed groups of mice was similar to that of the chamber control groups throughout the study. Mean body weights of 1,200 ppm females were slightly less than those of the chamber control group at the end of the study. Clinical findings included ataxia, shallow breathing, and lethargy in 1,200 ppm mice during the first 6 months of the study and pale foci of the eyes in 1,200 ppm females in the last month of the study. The incidences of hepatocellular adenoma, hepatocellular adenoma or carcinoma (combined), and hepatoblastoma occurred with positive trends in males and females, and the incidences in the 1,200 ppm groups were increased. The incidences of eosinophilic foci and multinucleated hepatocytes in 1,200 ppm males and eosinophilic foci in 1,200 ppm females were significantly increased. The incidence of mild corneal mineralization was significantly increased in 1,200 ppm females. GENETIC TOXICOLOGY: Propylene glycol mono-t-butyl ether was mutagenic in S. typhimurium strain TA97 in the absence of liver S9 activation enzymes; negative results were obtained with strain TA97 in the presence of rat or hamster liver S9 enzymes, in strains TA98, TA100, and TA1535 with and without S9, and in strain TA1537 without S9. Propylene glycol mono-t-butyl ether did not induce sister chromatid exchanges or chromosomal aberrations in Chinese hamster ovary cells, with or without S9. Propylene glycol mono-t-butyl ether induced a small but significant increase in the frequency of micronucleated normochromatic erythrocytes in peripheral blood of female mice in the 3-month study; no significant increase in micronucleated normochromatic erythrocytes was seen in male mice, and percentages of polychromatic erythrocytes were similar in the exposed and chamber control groups. CONCLUSIONS: Under the conditions of this 2-year inhalation study, there was equivocal evidence of carcinogenic activity of propylene glycol mono-t-butyl ether in male F344/N rats based on marginally increased incidences of renal tubule and liver neoplasms. There was no evidence of carcinogenic activity of propylene glycol mono-t-butyl ether in female F344/N rats exposed to 75, 300, or 1,200 ppm. There was clear evidence of carcinogenic activity of propylene glycol mono-t-butyl ether in male and female B6C3F1 mice based on increased incidences of liver neoplasms. Exposure of male rats to propylene glycol mono-t-butyl ether resulted in nonneoplastic lesions of the kidney characteristic of alpha2u-globulin accumulation. Exposure to propylene glycol mono-t-butyl ether resulted in nonneoplastic lesions of the liver and nose in male and female rats, the liver in male and female mice, and the eyes in female rats and mice. Kinetic and biomarker studies indicated that clearance was saturated at the 1,200 ppm exposure for both rats and mice.

Propylene glycol mono-t-butyl ether's production and use as a solvent for all-purpose cleaners, electronic chemicals, inks, adhesives, nail polish lacquers, and other water-reducible coatings(1) may result in its release to the environment through various waste streams(SRC).

TERRESTRIAL FATE: Based on a classification scheme(1), an estimated Koc value of 5(SRC), determined from a water solubility of 1.73X10+5 mg/L(2) and a regression-derived equation(3), indicates that propylene glycol mono-t-butyl ether is expected to have very high mobility in soil(SRC). Volatilization of propylene glycol mono-t-butyl ether from moist soil surfaces may be an important fate process(SRC) given an estimated Henry's Law constant of 4.73X10-6 atm-cu m/mole(SRC), derived from its vapor pressure, 4.7 mm Hg(2), and water solubility(2). The potential for volatilization of propylene glycol mono-t-butyl ether from dry soil surfaces may exist(SRC) based upon the estimated vapor pressure(2). The structurally similar compound 2-tertiary butoxy ethanol was not degraded in a 16 day BOD test(4). The authors reported that tertiary and ether structures are non-biodegradable. Based on the BOD test result for 2-tertiary butoxy ethanol(4), propylene glycol mono-t-butyl ether is not expected to biodegrade in soil(SRC).|AQUATIC FATE: Based on a classification scheme(1), an estimated Koc value of 5(SRC), determined from a water solubility of 1.73X10+5 mg/L(2) and a regression-derived equation(3), indicates that propylene glycol mono-t-butyl ether is not expected to adsorb to suspended solids and sediment(SRC). Volatilization from water surfaces is expected(3) based upon an estimated Henry's Law constant of 4.73X10-6 atm-cu m/mole(SRC), derived from its vapor pressure, 4.7 mm Hg(2), and water solubility(2). Using this Henry's Law constant and an estimation method(3), volatilization half-lives for a model river and model lake are 6 days and 69 days, respectively(SRC). According to a classification scheme(5), an estimated BCF of 0.8(SRC), from a measured water solubility(2) and a regression-derived equation(3), suggests the potential for bioconcentration in aquatic organisms is low(SRC). The structurally similar compound 2-tertiary butoxy ethanol was not degraded in a 16 day BOD test(6). The authors reported that tertiary and ether structures are non-biodegradable. Based on the BOD test result for 2-tertiary butoxy ethanol(6), propylene glycol mono-t-butyl ether is not expected to biodegrade in water(SRC).|ATMOSPHERIC FATE: According to a model of gas/particle partitioning of semivolatile organic compounds in the atmosphere(1), propylene glycol mono-t-butyl ether, which has a vapor pressure of 4.7 mm Hg at 20 °C(2), is expected to exist solely as a vapor in the ambient atmosphere. Vapor-phase propylene glycol mono-t-butyl ether is degraded in the atmosphere by reaction with photochemically-produced hydroxyl radicals(SRC); the half-life for this reaction in air is estimated to be 23 hours(SRC), calculated from its rate constant of 1.7X10-11 cu cm/molecule-sec at 25 °C(SRC) that was derived using a structure estimation method(3).

The rate constant for the vapor-phase reaction of propylene glycol mono-t-butyl ether with photochemically-produced hydroxyl radicals has been estimated as 1.71X10-11 cu cm/molecule-sec at 25 °C(SRC) using a structure estimation method(1). This corresponds to an atmospheric half-life of about 23 hours at an atmospheric concentration of 5X10+5 hydroxyl radicals per cu cm(1). Propylene glycol mono-t-butyl ether is not expected to undergo hydrolysis in the environment due to the lack of hydrolyzable functional groups(2) nor to directly photolyze due to the lack of absorption in the environmental UV spectrum (>290 nm).

An estimated BCF of 0.8 was calculated for propylene glycol mono-t-butyl ether(SRC), using a water solubility of 1.73X10+5 mg/L(1) and a regression-derived equation(2). According to a classification scheme(3), this BCF suggests the potential for bioconcentration in aquatic organisms is low(SRC).

The Koc of propylene glycol mono-t-butyl ether is estimated as 5(SRC), using a water solubility of 1.73X10+5 mg/L(1) and a regression-derived equation(2). According to a classification scheme(3), this estimated Koc value suggests that propylene glycol mono-t-butyl ether is expected to have very high mobility in soil.

The Henry's Law constant for propylene glycol mono-t-butyl ether is estimated as 4.73X10-6 atm-cu m/mole(SRC) derived from its vapor pressure, 4.7 mm Hg(1), and water solubility, 1.73X10+5 mg/L(1). This Henry's Law constant indicates that propylene glycol mono-t-butyl ether is expected to volatilize from water surfaces(2). Based on this Henry's Law constant, the volatilization half-life from a model river (1 m deep, flowing 1 m/sec, wind velocity of 3 m/sec)(2) is estimated as 6 days(SRC). The volatilization half-life from a model lake (1 m deep, flowing 0.05 m/sec, wind velocity of 0.5 m/sec)(2) is estimated as 69 days(SRC). Propylene glycol mono-t-butyl ether's estimated Henry's Law constant indicates that volatilization from moist soil surfaces may occur(SRC). The potential for volatilization of propylene glycol mono-t-butyl ether from dry soil surfaces may exist(SRC) based upon its vapor pressure(1).

Occupational exposure to propylene glycol mono-t-butyl ether may occur through inhalation and dermal contact with this compound at workplaces where propylene glycol mono-t-butyl ether is produced or used. The general population may be exposed to this compound through contact with consumer products containing propylene glycol mono-t-butyl ether. (SRC)

Propylene glycol mono-t-butyl ether (PGMBE) is a widely used solvent in industry and in consumer products, posing a potential for human exposure via inhalation or dermal routes. Toxicokinetic studies were conducted on F344/N rats and B6C3F1 mice of both sexes to evaluate single or repeated dose, species, and/or sex differences in PGMBE elimination kinetics following intravenous or inhalation exposure. In the first study, rats and mice received a single intravenous dose of 15 or 200 mg PGMBE/kg and serial blood samples were collected and analyzed for PGMBE. In the second study, rats and mice received a single 6-h whole-body inhalation exposure to 75, 300, or 1200 ppm PGMBE and serial blood samples were collected and analyzed for PGMBE. In the third study, rats and mice received whole-body inhalation exposures to 75, 300, or 1200 ppm PGMBE for 6 h/day, 5 days/wk for 14 (rats) or 16 (mice) wk. Serial blood samples were analyzed for PGMBE after 2, 6, 14 (rats), and 16 (mice) wk on study. Urine samples were also collected for 16 h postexposure and analyzed for creatinine and PGMBE sulfate and PGMBE glucuronide conjugates. These studies revealed that: (1) PGMBE was eliminated from blood following concentration-dependent nonlinear kinetics in both species; (2) saturable Michaelis-Menten kinetics were clearly exhibited following a single inhalation exposure at 1200 ppm, but were less obvious following repeated exposures; (3) mice were more efficient in eliminating PGMBE from blood at lower exposure concentrations (i.e., < or = 300 ppm), but at exposure concentrations potentially exceeding their elimination capacity, mice had a greater concentration-dependent decrease in PGMBE elimination than rats; (4) there were minimal but consistent sex differences in PGMBE elimination profiles for rats, with females having higher blood concentrations at all exposure concentrations and sampling times; and (5) sex differences in PGMBE elimination were in part associated with differences in urinary excretion of PGMBE metabolites.|...Propylene glycol mono-tert-butyl ether was found to be rapidly absorbed, metabolized, and excreted, largely within 24 hr via the urine, lungs (as carbon dioxide), and, to a lesser extent, the feces, after administration of a single oral dose to rats.

Urinary metabolites included sulfate and glucuronide conjugates of propylene glycol mono-tert-butyl ether and a small portion of parent compound.

SYMPTOMS: Symptoms of exposure to this compound via inhalation include coughing, shortness of breath, dizziness, drunkenness and collapse. Eye contact causes irritation. Prolonged skin contact may cause irritation. ACUTE/CHRONIC HAZARDS: This compound may be absorbed through the skin. When heated to decomposition it emits toxic fumes of carbon monoxide, carbon dioxide and unidentified organic compounds in black smoke. (NTP, 1992)

EYES: First check the victim for contact lenses and remove if present. Flush victim's eyes with water or normal saline solution for 20 to 30 minutes while simultaneously calling a hospital or poison control center. Do not put any ointments, oils, or medication in the victim's eyes without specific instructions from a physician. IMMEDIATELY transport the victim after flushing eyes to a hospital even if no symptoms (such as redness or irritation) develop. SKIN: IMMEDIATELY flood affected skin with water while removing and isolating all contaminated clothing. Gently wash all affected skin areas thoroughly with soap and water. If symptoms such as redness or irritation develop, IMMEDIATELY call a physician and be prepared to transport the victim to a hospital for treatment. INHALATION: IMMEDIATELY leave the contaminated area; take deep breaths of fresh air. If symptoms (such as wheezing, coughing, shortness of breath, or burning in the mouth, throat, or chest) develop, call a physician and be prepared to transport the victim to a hospital. Provide proper respiratory protection to rescuers entering an unknown atmosphere. Whenever possible, Self-Contained Breathing Apparatus (SCBA) should be used; if not available, use a level of protection greater than or equal to that advised under Protective Clothing. INGESTION: If the victim is conscious and not convulsing, give 1 or 2 glasses of water to dilute the chemical and IMMEDIATELY call a hospital or poison control center. Be prepared to transport the victim to a hospital if advised by a physician. If the victim is convulsing or unconscious, do not give anything by mouth, ensure that the victim's airway is open and lay the victim on his/her side with the head lower than the body. DO NOT INDUCE VOMITING. IMMEDIATELY transport the victim to a hospital. (NTP, 1992)

Fresh air, rest.

Remove contaminated clothes. Rinse skin with plenty of water or shower.

First rinse with plenty of water for several minutes (remove contact lenses if easily possible), then refer for medical attention.

Basic treatment: Establish a patent airway. Suction if necessary. Watch for signs of respiratory insufficiency and assist ventilations if needed. Administer oxygen by nonrebreather mask at 10 to 15 L/min. Monitor for pulmonary edema and treat if necessary ... . Monitor for shock and treat if necessary ... . Anticipate seizures and treat if necessary ... . For eye contamination, flush eyes immediately with water. Irrigate each eye continuously with normal saline during transport ... . Do not use emetics. For ingestion, rinse mouth and administer 5 ml/kg up to 200 ml of water for dilution if the patient can swallow, has a strong gag reflex, and does not drool ... . Cover skin burns with dry sterile dressings after decontamination ... . /Poison A and B/|Advanced treatment: Consider orotracheal or nasotracheal intubation for airway control in the patient who is unconscious, has severe pulmonary edema, or is in respiratory arrest. Positive pressure ventilation techniques with a bag valve mask device may be beneficial. Monitor cardiac rhythm and treat arrhythmias as necessary ... . Start an IV with D5W /SRP: "To keep open", minimal flow rate/. Use lactated Ringer's if signs of hypovolemia are present. Watch for signs of fluid overload. Consider drug therapy for pulmonary edema ... . For hypotension with signs of hypovolemia, administer fluid cautiously. Watch for signs of fluid overload ... . Treat seizures with diazepam (Valium) ... . Use proparacaine hydrochloride to assist eye irrigation ... . /Poison A and B/

propylene glycol mono-t-butyl ether

The substance can be absorbed into the body by inhalation of its vapour.

Redness. Pain.

Alpha isomer: 1-(1,1-dimethylethoxy)-2-propanol, 1-tertiary-butoxypropan-2-ol. Beta isomer: 2-(1,1-dimethylethoxy)-1-propanol, 2-tertiary-butoxypropan-1-ol.|Trade name: Arcosolv PTB

2-Propanol, 1-(1,1-dimethylethoxy)-: ACTIVE|PMN - indicates a commenced PMN (Pre-Manufacture Notices) substance.