Polyoxin
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Polyoxin
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CAS No:
11113-80-7
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Formula:
C11H13N3O8
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Chemical Name:
Polyoxin
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Synonyms:
1-[(2R,3R,4S,5R)-5…;1-[(2R,3R,4S,5R)-5-(1-amino-2-oxoethyl)-3,4-dihydroxyoxolan-2-yl]-2,4-dioxopyrimidine-5-carboxylic acid;16%Polyoxin;3%Polyoxin;10%Polyoxin;POLYOXINS
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CAS No:
Description
Polyoxin was found in the culture broth of Streptomyces cacaoi var. asoensis by Suzuki et al. in 1965. It consists of several closely related components, A through O, and shows activity against phytopathogenic fungi by inhibition of cell-wall chitin synthesis. Polyoxin has been used in agriculture against fungal infections, especially Alternaria leaf spot in vegetables and fruits.
Characteristics
Acute oral LD50of polyoxin B for male rats 21, female rats 21.2, male mice 27.3, and femalemice 22.5 g/kg. Acute percutaneous LD50for rats >2 g/kg. Nonirritant to mucous membranes and skin (rats). Inhalation LD50(6 h) for rats 10 mg/L air. NOEL (2 y) for rats and mice >48-g/kg diet. Toxicity class EPA (formulation) IV.Acute oral LD50of polyoxin D for male rats and female rats >9.6 g/kg. Acute percutaneous LD50for rats >750 mg/kg. Inhalation LD50(4 h) for male rats 2.44, female rats 2.17 mg/L air. NOEL (2 y) for rats >50, mice >40 g/kg diet. Toxicity class EPA (formulation) III (WP).
Polyoxin Use and Manufacturing
The fungicidal activities of polyoxins reported on many plant pathogens, including Alternaria spp. and Rhizoctonia zoctonia spp. (24,25).Polyoxin B is used for control of Alternaria spp. and powdery mildews in apples and pears; Botrytis cinerea in vines and aubergines; powdery mildews in roses, chrysanthemums, and melons; blight of carnation; powdery mildew, brown spot, and gray mold in tobacco; powdery mildew and gray mold in strawberries; leaf mold, early blight, and gray mold in tomatoes; powdery mildew, gray mold, Sclerotinia erotinia spp. rot, and Corynespora melonis in cucumbers; Alternaria spp. blight in carrots; purple blotch in leeks. Patent: JP 493008 Formulation types: WP; EC; SG. Mixes with captan; oxine-copper; iminoctadine triacetate. Compatibility: Incompatible with alkaline materials. Tradename “Polyoxin AL.”Polyoxin D zinc salt is used for control of sheath blight (Rhizoctonia solani) in rice; canker in apples and pears; Rhizoctonia solani, Drechslera spp., Bipolaris spp., Curvularia spp., and Helminthosporium spp. in lawn turf. Formulation types: WP; PA. Mixes with thiram; propiconazole. Compatibility: Incompatible with alkaline materials. Tradenames “Kakengel” (zinc salt); “Polyoxin Z” (zinc salt); “Stopit.”Application of polyoxins can be made at any growth stage of rice plants without causing phytotoxicity even at 800-ppm application. Foliar sprays of 200 ppm of polyoxins have produced no phytotoxicity on all the other crops tested.
Agrochemicals -> Fungicides