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Polyoxin

Polyoxin structure

Polyoxin 

structure
  • CAS No:

    11113-80-7

  • Formula:

    C11H13N3O8

  • Chemical Name:

    Polyoxin

  • Synonyms:

    1-[(2R,3R,4S,5R)-5…;1-[(2R,3R,4S,5R)-5-(1-amino-2-oxoethyl)-3,4-dihydroxyoxolan-2-yl]-2,4-dioxopyrimidine-5-carboxylic acid;16%Polyoxin;3%Polyoxin;10%Polyoxin;POLYOXINS

Description

Polyoxin was found in the culture broth of Streptomyces cacaoi var. asoensis by Suzuki et al. in 1965. It consists of several closely related components, A through O, and shows activity against phytopathogenic fungi by inhibition of cell-wall chitin synthesis. Polyoxin has been used in agriculture against fungal infections, especially Alternaria leaf spot in vegetables and fruits.

Polyoxin Basic Attributes

315.23622

315.07026438

Characteristics

Acute oral LD50of polyoxin B for male rats 21, female rats 21.2, male mice 27.3, and femalemice 22.5 g/kg. Acute percutaneous LD50for rats >2 g/kg. Nonirritant to mucous membranes and skin (rats). Inhalation LD50(6 h) for rats 10 mg/L air. NOEL (2 y) for rats and mice >48-g/kg diet. Toxicity class EPA (formulation) IV.Acute oral LD50of polyoxin D for male rats and female rats >9.6 g/kg. Acute percutaneous LD50for rats >750 mg/kg. Inhalation LD50(4 h) for male rats 2.44, female rats 2.17 mg/L air. NOEL (2 y) for rats >50, mice >40 g/kg diet. Toxicity class EPA (formulation) III (WP).

Drug Information

polyoxin

Polyoxin Use and Manufacturing

Uses

The fungicidal activities of polyoxins reported on many plant pathogens, including Alternaria spp. and Rhizoctonia zoctonia spp. (24,25).Polyoxin B is used for control of Alternaria spp. and powdery mildews in apples and pears; Botrytis cinerea in vines and aubergines; powdery mildews in roses, chrysanthemums, and melons; blight of carnation; powdery mildew, brown spot, and gray mold in tobacco; powdery mildew and gray mold in strawberries; leaf mold, early blight, and gray mold in tomatoes; powdery mildew, gray mold, Sclerotinia erotinia spp. rot, and Corynespora melonis in cucumbers; Alternaria spp. blight in carrots; purple blotch in leeks. Patent: JP 493008 Formulation types: WP; EC; SG. Mixes with captan; oxine-copper; iminoctadine triacetate. Compatibility: Incompatible with alkaline materials. Tradename “Polyoxin AL.”Polyoxin D zinc salt is used for control of sheath blight (Rhizoctonia solani) in rice; canker in apples and pears; Rhizoctonia solani, Drechslera spp., Bipolaris spp., Curvularia spp., and Helminthosporium spp. in lawn turf. Formulation types: WP; PA. Mixes with thiram; propiconazole. Compatibility: Incompatible with alkaline materials. Tradenames “Kakengel” (zinc salt); “Polyoxin Z” (zinc salt); “Stopit.”Application of polyoxins can be made at any growth stage of rice plants without causing phytotoxicity even at 800-ppm application. Foliar sprays of 200 ppm of polyoxins have produced no phytotoxicity on all the other crops tested.

Agrochemicals -> Fungicides

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